279 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
**n-Yi Wang
Article
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Article
Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
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Open AccessPI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma
Inositol polyphosphate 5-phosphatases can terminate downstream signalling of phosphatidylinositol-3 kinase; however, their biological role in the pathogenesis of cancer is controversial. Here we report that th...
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Open AccessCadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site
The heavy metal cadmium is a non-degradable pollutant. By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G...
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Open AccessEfficient and tunable white-light emission of metal–organic frameworks by iridium-complex encapsulation
Metal–organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be furthe...
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Open AccessGenomewide Analysis of Rat Periaqueductal Gray-Dorsal Horn Reveals Time-, Region- and Frequency-Specific mRNA Expression Changes in Response to Electroacupuncture Stimulation
Electroacupuncture (EA) has been widely applied for illness prevention, treatment or rehabilitation in the clinic, especially for pain management. However, the molecular events that induce these changes remain...
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Open AccessNon-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target
N-acylhomoserine lactone (AHL)-based quorum sensing (QS) is important for the regulation of proteobacterial virulence determinants. Thus, the inhibition of AHL synthases offers non-antibiotics-based therapeutic.....
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Open AccessLevodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats
L-3, 4-dihydroxyphenylalanine (L-dopa) is the gold standard for symptomatic treatment of Parkinson's disease (PD), but long-term therapy is associated with the emergence of L-dopa-induced dyskinesia (LID). In ...
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Open AccessThe catalytic role of the M2 metal ion in PP2Cα
PP2C family phosphatases (the type 2C family of protein phosphatases; or metal-dependent phosphatase, PPM) constitute an important class of signaling enzymes that regulate many fundamental life activities. All...
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Open AccessA Graphene-Based Resistive Pressure Sensor with Record-High Sensitivity in a Wide Pressure Range
Pressure sensors are a key component in electronic skin (e-skin) sensing systems. Most reported resistive pressure sensors have a high sensitivity at low pressures (<5 kPa) to enable ultra-sensitive detection....
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Open AccessAn effective biphase system accelerates hesperidinase-catalyzed conversion of rutin to isoquercitrin
Isoquercitrin is a rare, natural ingredient with several biological activities that is a key precursor for the synthesis of enzymatically modified isoquercitrin (EMIQ). The enzymatic production of isoquercitri...
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Open AccessTranscriptome comparison of the sex pheromone glands from two sibling Helicoverpa species with opposite sex pheromone components
Differences in sex pheromone component can lead to reproductive isolation. The sibling noctuid species, Helicoverpa armigera and Helicoverpa assulta, share the same two sex pheromone components, Z9-16:Ald and Z11...
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Open AccessLarge-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
Our ability to model the dynamics of signal transduction networks will depend on accurate methods to quantify levels of protein phosphorylation on a global scale. Here we describe a motif-targeting quantitatio...
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Open AccessA decline of LAMP- 2 predicts ursodeoxycholic acid response in primary biliary cirrhosis
Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. We have previously reported that augmented expression of lysosome-associated membrane protein 2...
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Open AccessIdentification of new susceptibility loci for IgA nephropathy in Han Chinese
IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. To identify novel susceptib...
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Open AccessY-junction carbon nanocoils: synthesis by chemical vapor deposition and formation mechanism
Y-junction carbon nanocoils (Y-CNCs) were synthesized by thermal chemical vapor deposition using Ni catalyst prepared by spray-coating method. According to the emerging morphologies of Y-CNCs, several growth m...
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Open AccessPPL2ab neurons restore sexual responses in aged Drosophila males through dopamine
Male sexual desire typically declines with ageing. However, our understanding of the neurobiological basis for this phenomenon is limited by our knowledge of the brain circuitry and neuronal pathways controlli...
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Open AccessTransforming berberine into its intestine-absorbable form by the gut microbiota
The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on the interaction between intestinal bacteria and orally administered chemical drugs. Oral administration ...
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Open AccessTMPRSS4 facilitates epithelial-mesenchymal transition of hepatocellular carcinoma and is a predictive marker for poor prognosis of patients after curative resection
TMPRSS4 (Transmembrane protease serine 4) is up-regulated in a broad spectrum of cancers. However, little is known about the biological effects of TMPRSS4 on hepatocellular carcinoma (HCC) and the related mech...
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Open AccessModeling the transmission dynamics of Ebola virus disease in Liberia
Ebola virus disease (EVD) has erupted many times in some zones since it was first found in 1976. The 2014 EVD outbreak in West Africa is the largest ever, which has caused a large number of deaths and the most...
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Open AccessDiscovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors
Human epidermal growth factor receptor (EGFR) is an important drug target that plays a fundamental role in signal transduction pathways in oncology. We report herein the discovery of a novel class of phenylpip...
