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  1. Article

    Open Access

    First-line hepatic arterial infusion chemotherapy plus lenvatinib and PD-(L)1 inhibitors versus systemic chemotherapy alone or with PD-(L)1 inhibitors in unresectable intrahepatic cholangiocarcinoma

    Limited treatment options exist for unresectable intrahepatic cholangiocarcinoma (ICC), with systemic chemotherapy (SC) serving as the primary approach. This study aimed to assess the effectiveness of first-li...

    Yan-Song Lin, Shuo Li, **a Yang in Journal of Cancer Research and Clinical On… (2024)

  2. Article

    Open Access

    Novel prognostic nomograms for postoperative patients with oral cavity squamous cell carcinoma in the central region of China

    Oral cavity squamous cell carcinoma (OCSCC) is the most common pathological type in oral tumors. This study intends to construct a novel prognostic nomogram model based on China populations for these resectabl...

    Xue-Lian Xu, **-Hong Xu, Jia-Qi He, Yi-Hao Li, Hao Cheng in BMC Cancer (2024)

  3. No Access

    Article

    Disruption of DNA-PKcs-mediated cGAS retention on damaged chromatin potentiates DNA damage-inducing agent-induced anti-multiple myeloma activity

    Targeting DNA damage repair factors, such as DNA-dependent protein kinase catalytic subunit (DNA-PKcs), may offer an opportunity for effective treatment of multiple myeloma (MM). In combination with DNA damage...

    **-Na Zhang, Meng-Meng Dong, Wen Cao, Hao-Guang Chen in British Journal of Cancer (2024)

  4. Article

    Open Access

    METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

    Without intervention, a considerable proportion of patients with metabolism‐associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism‐associated steatohepatitis (MASH), liver fib...

    Yue-fan Wang, Wen-li Zhang, Zhi-xuan Li in Signal Transduction and Targeted Therapy (2024)

  5. Article

    Open Access

    Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity

    During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac remodeling. Therefore, the effects and mechanisms of microgravity on cardiac morpholo...

    **nglong Han, Lina Qu, Miao Yu, Lingqun Ye in Signal Transduction and Targeted Therapy (2024)

  6. Article

    Open Access

    Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

    RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in col...

    Ri-**n Chen, Shui-Dan Xu, Min-Hua Deng in Signal Transduction and Targeted Therapy (2024)

  7. No Access

    Article

    IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling

    Previously, Interferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) has been shown to promote cancer development. Here, we aimed to explore the role of IFIT1 in the development and progression of p...

    Tian-Hao Li, Bang-Bo Zhao, Cheng Qin, Yuan-Yang Wang, Ze-Ru Li in Cellular Oncology (2024)

  8. Article

    Open Access

    ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia

    In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly under...

    Tao-Yan Lin, Jun-Shuang Jia, Wei-Ren Luo in Journal of Experimental & Clinical Cancer … (2024)

  9. Article

    Open Access

    METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation

    While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains...

    Meilin Xue, Lei Dong, Honghai Zhang, Yangchan Li in Journal of Hematology & Oncology (2024)

  10. Article

    Open Access

    Retraction Note: IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling

    Tian-Hao Li, Bang-Bo Zhao, Cheng Qin, Yuan-Yang Wang, Ze-Ru Li in Cellular Oncology (2023)

  11. Article

    Open Access

    Venetoclax plus hypomethylating agents in newly diagnosed acute myeloid leukemia patients with RUNX1::RUNX1T1: a retrospective propensity score matching study

    Miao Wang, Han-Yu Cao, Kai-Wen Tan, Qiao-Cheng Qiu, Yuan-Hong Huang in Blood Cancer Journal (2023)

  12. No Access

    Article

    MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K/AKT/mTOR pathway

    Previous studies have indicated that neurotransmitters play important roles in the occurrence and development of gastric cancer. MAOA is an important catecholamine neurotransmitter-degrading enzyme involved in...

    Yang-Yang Wang, Yao-Qi Zhou, Jia-Xuan **e, **ang Zhang, Shu-Chang Wang in Cellular Oncology (2023)

  13. Article

    Open Access

    The prognostic significance of histologic variant on survival outcomes in patients with metastatic urothelial carcinoma receiving immune checkpoint inhibitor therapy

    While the treatment guidelines have been established for pure urothelial carcinoma (pUC), patients with variant type urothelial carcinoma (vUC) face limited effective treatment options. The effectiveness of im...

    Tsung-Han Tsai, Po-Jung Su, Shih-Yu Huang, Ming-Chun Kuo, Chang-Ting Lin in BMC Cancer (2023)

  14. Article

    Open Access

    Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis

    T lymphopenia, occurring in the early phase of sepsis in response to systemic inflammation, is commonly associated with morbidity and mortality of septic infections. We have previously shown that a sufficient ...

    Sheng-yuan Zhang, Qiu-** Xu, Li-na Shi in Signal Transduction and Targeted Therapy (2023)

  15. Article

    Open Access

    Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke

    Acute ischemic stroke (AIS) is a major cause of disability and mortality worldwide. Non-cardioembolic ischemic stroke (NCIS), which constitutes the majority of AIS cases, is highly heterogeneous, thus requirin...

    Lingling Ding, Yu Liu, **a Meng, Yong Jiang in Signal Transduction and Targeted Therapy (2023)

  16. Article

    Open Access

    First-in-human phase I/Ib study of QL1706 (PSB205), a bifunctional PD1/CTLA4 dual blocker, in patients with advanced solid tumors

    QL1706 (PSB205) is a single bifunctional MabPair (a novel technical platform) product consisting of two engineered monoclonal antibodies (anti-PD-1 IgG4 and anti-CTLA-4 IgG1), with a shorter elimination half-l...

    Yuanyuan Zhao, Yuxiang Ma, Aimin Zang, Ying Cheng in Journal of Hematology & Oncology (2023)

  17. Article

    Open Access

    Assessment of Autologous Blood marker localIzation and intraoperative coLonoscopy localIzation in laparoscopic colorecTal cancer surgery (ABILITY): a randomized controlled trial

    Laparoscopic colorectal surgery has been proved to have similar oncological outcomes with open surgery. Due to the lack of tactile perception, surgeons may have misjudgments in laparoscopic colorectal surgery....

    Ke-hui Zhang, **g-ze Li, Hai-bin Zhang, Ren-hao Hu, **-mao Cui, Tao Du in BMC Cancer (2023)

  18. Article

    Open Access

    Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

    There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

    Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang in Signal Transduction and Targeted Therapy (2023)

  19. Article

    Open Access

    Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders: phase 1 trial interim results

    Chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA) have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis o...

    Chuan Qin, Dai-Shi Tian, Luo-Qi Zhou, Ke Shang in Signal Transduction and Targeted Therapy (2023)

  20. Article

    Open Access

    Clinical characteristics and prognostic factors affecting survival after radical radiotherapy for early and late post-treatment metastatic nasopharyngeal carcinoma

    We compared the clinical characteristics and survival outcomes after radical radiotherapy between nasopharyngeal carcinoma (NPC) with early and late metastases based on a relatively large cohort, which provide...

    Guo-Dong Jia, Xue-Song Sun, **ao-Yun Li, Sai-Lan Liu, **-Hao Yang in BMC Cancer (2023)

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