-
Article
Open AccessGenome wide identification of novel DNA methylation driven prognostic markers in colorectal cancer
Colorectal cancer (CRC) stands as a major contributor to cancer-related fatalities within China. There is an urgent need to identify accurate biomarkers for recurrence predicting in CRC. Reduced representation...
-
Article
Open AccessA multimodal cancer rehabilitation programme promoting sense of coherence for women treated for female reproductive cancers: a pilot randomised controlled trial
To investigate the feasibility, acceptability, and preliminary effects of a theory-driven multimodal cancer rehabilitation intervention (MCRI) programme among Hong Kong Chinese women treated for female reprodu...
-
Article
Open AccessAssociation of serum interleukin-2 with severity and prognosis in hospitalized patients with community-acquired pneumonia: a prospective cohort study
The prior studies have shown that interleukin-2 (IL-2) exerts important roles in the pathological and physiological processes of lung diseases. However, the role of IL-2 in community-acquired pneumonia (CAP) i...
-
Article
Beyond 600G fiber-THz wireless seamless integration system employing cascaded MIMO equalizers
-
Article
Open AccessAntitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4
The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has potential for enhancing clinical efficacy. We described the development and antitumor acti...
-
Article
Open AccessIntraocular pressure control efficacy and safety of HA-Mg glaucoma drainage plate implantation in the anterior chamber of rabbit eyes
The current clinical application of glaucoma drainage devices is made of non-degradable materials. These non-degradable drainage devices often trigger inflammatory responses and scar proliferation, possibly le...
-
Article
Open AccessImpact of COVID-19 on jump occurrence in capital markets
In this paper, we investigate the relationship between the indicators for COVID-19 monitoring and the dynamic of jumps across six major financial markets including China, France, Italy, Germany, the UK, and th...
-
Article
Open AccessGlobal overview of anterior cruciate ligament reconstruction in children and adolescents over the past 20 years: a bibliometric analysis
The objectives of this paper is to conduct a bibliometric analysis to examine the research status and development trend of anterior cruciate ligament injury and reconstruction in children and adolescents over ...
-
Article
Open AccessMDI versus CSII in Chinese adults with type 1 diabetes in a real-world situation: based on propensity score matching method
Compared with multiple daily insulin injections (MDI), continuous subcutaneous insulin infusion (CSII) is significantly more expensive and has not been widely used in Chinese type 1 diabetes mellitus (T1DM) pa...
-
Article
Open AccessTime-dependent efficacy analysis of first-line immunotherapies for advanced non–small cell lung cancer
Many randomized controlled trials (RCTs) and network meta-analyses have demonstrated that the progression-free survival (PFS) and overall survival (OS) of advanced non-small cell lung cancer (NSCLC) patients c...
-
Article
Open AccessProphylactic donor-derived CD19 CAR-T cell infusion for preventing relapse in high-risk B-ALL after allogeneic hematopoietic stem cell transplantation
-
Article
Open AccessEffects of Dietary Valine Chelated Zinc Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Intestine Health in Weaned Piglets
This study was conducted to investigate the effects of dietary valine chelated zinc (ZnVal) supplementation on growth performance, antioxidant capacity, immunity, and intestine health in weaned piglets. A tota...
-
Article
Open AccessIdentifying novel clinical phenotypes of acute respiratory distress syndrome using trajectories of daily fluid balance: a secondary analysis of randomized controlled trials
Previously identified phenotypes of acute respiratory distress syndrome (ARDS) could not reveal the dynamic change of phenotypes over time. We aimed to identify novel clinical phenotypes in ARDS using trajecto...
-
Article
Open AccessInfectious factors in myocarditis: a comprehensive review of common and rare pathogens
Myocarditis is a significant health threat today, with infectious agents being the most common cause. Accurate diagnosis of the etiology of infectious myocarditis is crucial for effective treatment.
-
Article
Open AccessPrognostic and predictive value of interstitial lung abnormalities and EGFR mutation status in patients with non-small cell lung cancer
To determine the predictive value of interstitial lung abnormalities (ILA) for epidermal growth factor receptor (EGFR) mutation status and assess the prognostic significance of EGFR and ILA in patients with no...
-
Article
Open AccessHealthcare preferences of chronic disease patients under China's hierarchical medical system: an empirical study of Tian**'s reform practice
To alleviate the contradiction in healthcare resources, the Chinese government formally established the framework of a hierarchical medical system in 2015, which contains the following brief generalities: " se...
-
Article
Open AccessRGG-PSO+: Random Geometric Graphs Based Particle Swarm Optimization Method for UAV Path Planning
Evolutionary algorithms, such as particle swarm optimization (PSO), are widely applied to UAV path planning problems. However, the fixed particle length of PSO, which may not be suitable for the scenario, will...
-
Article
Open AccessA humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer
Gastric cancer represents a highly lethal malignancy with an elevated mortality rate among cancer patients, coupled with a suboptimal postoperative survival prognosis. Nectin-4, an overexpressed oncological ta...
-
Article
Open AccessA pathological joint–liver axis mediated by matrikine-activated CD4+ T cells
The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint dama...
-
Article
Open AccessPhysiological and pathological functions of TMEM106B in neurodegenerative diseases
As an integral lysosomal transmembrane protein, transmembrane protein 106B (TMEM106B) regulates several aspects of lysosomal function and is associated with neurodegenerative diseases. The TMEM106B gene mutati...
