19 Result(s)
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Article
**meng Hu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCross-species spill-over potential of the H9N2 bat influenza A virus
In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bir...
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Open AccessHigh-performance ferroelectric field-effect transistors with ultra-thin indium tin oxide channels for flexible and transparent electronics
With the development of wearable devices and hafnium-based ferroelectrics (FE), there is an increasing demand for high-performance flexible ferroelectric memories. However, develo** ferroelectric memories th...
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Open AccessA longitudinal resource for population neuroscience of school-age children and adolescents in China
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...
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Open AccessVisual field prediction using a deep bidirectional gated recurrent unit network model
Although deep learning architecture has been used to process sequential data, only a few studies have explored the usefulness of deep learning algorithms to detect glaucoma progression. Here, we proposed a bid...
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Open AccessHypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice
Manufacturing autologous chimeric antigen receptor (CAR) T cell therapeutics is complex, and many patients experience treatment delays or cannot be treated at all. Although current allogeneic CAR products have...
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Open AccessEstimating the time of last drinking from blood ethyl glucuronide and ethyl sulphate concentrations
The determination of length of time from the last drinking is critical for cases like drunk driving, sexual assault victims, and also postmortem suspected poisoning cases. The study was aimed to established a ...
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Open AccessDecoding kinase-adverse event associations for small molecule kinase inhibitors
Small molecule kinase inhibitors (SMKIs) are being approved at a fast pace under expedited programs for anticancer treatment. In this study, we construct a multi-domain dataset from a total of 4638 patients in...
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Open AccessImpact of different enzymes on biofilm formation and mussel settlement
Enzymes have been known to impact the biofilm forming capacity. However, how the enzymes mediate the biofilm formation and macrofouling remains little known. Here, we investigated the effects of the three kind...
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Open AccessSingle-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma
Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor...
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Open AccessUrate in fingernail represents the deposition of urate burden in gout patients
Urate in the fingernails of gout patients and healthy volunteers was successfully detected by high-performance liquid chromatography (HPLC) with ultraviolet (UV) in our previous research. This study aimed to f...
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Open AccessMachine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma
Early cancer detection greatly increases the chances for successful treatment, but available diagnostics for some tumours, including lung adenocarcinoma (LA), are limited. An ideal early-stage diagnosis of LA ...
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Open AccessGenotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
The mechanisms underlying how cells subjected to genotoxic stress reestablish reduction-oxidation (redox) homeostasis to scavenge genotoxic stress-induced reactive oxygen species (ROS), which maintains the phy...
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Open AccessCombinatorial metabolic engineering using an orthogonal tri-functional CRISPR system
Designing an optimal microbial cell factory often requires overexpression, knock-down, and knock-out of multiple gene targets. Unfortunately, such rewiring of cellular metabolism is often carried out sequentia...
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Open AccessFocal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis
Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cel...
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Open AccessLipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
Hyperactivated Ras regulates many oncogenic pathways in several malignant human cancers including glioblastoma and it is an attractive target for cancer therapies. Ras activation in cancer cells drives protein in...
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Open AccessAmino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus
The PA N-terminal domain (PA-Nter) is essential for viral transcription and replication. Here we identified PA-Nter substitutions A37S, I61T, V63I and V100A in recently emerged avian influenza A viruses (IAVs)...
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Open AccessA new phase from compression of carbon nanotubes with anisotropic Dirac fermions
Searching for novel functional carbon materials is an enduring topic of scientific investigations, due to its diversity of bonds, including sp-, sp2- and sp3-hybridized bonds. Here we predict a new carbon allotro...
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Open AccessS100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase
S100A4 expression is associated with poor clinical outcomes of patients with pancreatic cancer. The effects of loss or gain of S100A4 were examined in pancreatic cancer cell lines. S100A4 downregulation remark...
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Open AccessCompressed carbon nanotubes: A family of new multifunctional carbon allotropes
The exploration of novel functional carbon polymorphs is an enduring topic of scientific investigations. In this paper, we present simulations demonstrating metastable carbon phases as the result of pressure i...
