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  1. No Access

    Article

    Protective Autophagy Attenuates the Cytotoxicity of MTI-31 in Renal Cancer Cells by Activating the ERK Pathway

    The mammalian target of rapamycin (mTOR) is a key regulatory molecular target to treat cancer, and MTI-31 is a potent mTOR inhibitory agent for the therapeutically target of the renal cell carcinoma (RCC). How...

    Yiwen Zang, Chen Yang, Meng-shi Dai, Wenye Zhang… in Applied Biochemistry and Biotechnology (2024)

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    Article

    Performance of combined fragmentation and retention prediction for the identification of organic micropollutants by LC-HRMS

    In nontarget screening, structure elucidation of small molecules from high resolution mass spectrometry (HRMS) data is challenging, particularly the selection of the most likely candidate structure among the m...

    Meng Hu, Erik Müller, Emma L. Schymanski… in Analytical and Bioanalytical Chemistry (2018)

  3. No Access

    Article

    Optimization of LC-Orbitrap-HRMS acquisition and MZmine 2 data processing for nontarget screening of environmental samples using design of experiments

    Liquid chromatography–high resolution mass spectrometry (LC-HRMS) is a well-established technique for nontarget screening of contaminants in complex environmental samples. Automatic peak detection is essential...

    Meng Hu, Martin Krauss, Werner Brack… in Analytical and Bioanalytical Chemistry (2016)

  4. No Access

    Article

    Modern analytics for synthetically derived complex drug substances: NMR, AFFF–MALS, and MS tests for glatiramer acetate

    Glatiramer acetate (GA) is a mixture of synthetic copolymers consisting of four amino acids (glutamic acid, lysine, alanine, and tyrosine) with a labeled molecular weight range of 5000 to 9000 Da. GA is market...

    Sarah Rogstad, Eric Pang, Cynthia Sommers… in Analytical and Bioanalytical Chemistry (2015)