210 Result(s)
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Open AccessSingle-cell atlas of the human brain vasculature across development, adulthood and disease
A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain v...
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Open AccessHumid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice
Climate and environmental changes threaten human mental health, but the impacts of specific environmental conditions on neuropsychiatric disorders remain largely unclear. Here, we show the impact of a humid he...
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Open AccessDeterministic positioning and alignment of a single-molecule exciton in plasmonic nanodimer for strong coupling
Experimental realization of strong coupling between a single exciton and plasmons remains challenging as it requires deterministic positioning of the single exciton and alignment of its dipole moment with the ...
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Open AccessDegradation of edible mushroom waste by Hermetia illucens L. and consequent adaptation of its gut microbiota
The edible fungus industry is one of the pillar industries in the Yunnan–Guizhou Plateau, China. The expansion of the planting scale has led to the release of various mushroom residues, such as mushroom feet, ...
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Open AccessOrigami metamaterials for ultra-wideband and large-depth reflection modulation
The dynamic control of electromagnetic waves is a persistent pursuit in modern industrial development. The state-of-the-art dynamic devices suffer from limitations such as narrow bandwidth, limited modulation ...
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Open AccessOptically induced charge-transfer in donor-acceptor-substituted p- and m- C2B10H12 carboranes
Icosahedral carboranes, C2B10H12, have long been considered to be aromatic but the extent of conjugation between these clusters and their substituents is still being debated. m- and p-Carboranes are compared with...
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Open AccessCurcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model
Knee osteoarthritis (KOA) usually leads to quadriceps femoris atrophy, which in turn can further aggravate the progression of KOA. Curcumin (CUR) has anti-inflammatory and antioxidant effects and has been show...
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Open AccessA dataset for fine-grained seed recognition
The research of plant seeds has always been a focus of agricultural and forestry research, and seed identification is an indispensable part of it. With the continuous application of artificial intelligence tec...
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Deep whole-genome analysis of 494 hepatocellular carcinomas
Over half of hepatocellular carcinoma (HCC) cases diagnosed worldwide are in China1–3. However, whole-genome analysis of hepatitis B virus (HBV)-associated HCC in Chinese individuals is limited4–8, with current a...
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Self-enhanced mobility enables vortex pattern formation in living matter
Ranging from subcellular organelle biogenesis to embryo development, the formation of self-organized structures is a hallmark of living systems. Whereas the emergence of ordered spatial patterns in biology is ...
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Open AccessTemporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders
Approximately 36% of patients with neuromyelitis optica spectrum disorders (NMOSD) suffer from severe visual and motor disability (blindness or light perception or unable to walk) with abnormalities of whole-b...
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Open AccessA pivotal bridging study of lurbinectedin as second-line therapy in Chinese patients with small cell lung cancer
This single-arm, multi-center clinical trial aimed to evaluate the safety, tolerability, DLT, recommended dose (RD), preliminary efficacy, and pharmacokinetics (PK) characteristics of lurbinectedin, a selectiv...
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Open AccessRisk factors for instent restenosis of sirolimus-coated stents in coronary intervention for patients with unstable angina
To investigate the instent restenosis rate of sirolimus-coated stents in percutaneous coronary intervention (PCI) and risk factors for in-stent restenosis, patients with unstable angina (UA) caused by coronary...
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Open AccessGlioPredictor: a deep learning model for identification of high-risk adult IDH-mutant glioma towards adjuvant treatment planning
Identification of isocitrate dehydrogenase (IDH)-mutant glioma patients at high risk of early progression is critical for radiotherapy treatment planning. Currently tools to stratify risk of early progression are...
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Open AccessDevelopment of macrophage-associated genes prognostic signature predicts clinical outcome and immune infiltration for sepsis
Sepsis is a major global health problem, causing a significant burden of disease and death worldwide. Risk stratification of sepsis patients, identification of severe patients and timely initiation of treatmen...
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Open AccessEffects of foot reflexology massage on pregnant women: a systematic review and meta-analysis of randomized controlled studies
To explore the effects of foot reflexology massage on anxiety, pain, duration of labor, labor satisfaction, blood pressure, pulse rate and respiratory rate in pregnant women. We systematically searched eight d...
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Open AccessInterfacial self-healing polymer electrolytes for long-cycle solid-state lithium-sulfur batteries
Coupling high-capacity cathode and Li-anode with solid-state electrolyte has been demonstrated as an effective strategy for increasing the energy densities and safety of rechargeable batteries. However, the li...
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Open AccessExploring shared therapeutic targets in diabetic cardiomyopathy and diabetic foot ulcers through bioinformatics analysis
Advanced diabetic cardiomyopathy (DCM) patients are often accompanied by severe peripheral artery disease. For patients with DCM combined with diabetic foot ulcer (DFU), there are currently no good therapeutic...
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Open AccessImproved chromosome-level genome assembly of Indian sandalwood (Santalum album)
Santalum album is a well-known aromatic and medicinal plant that is highly valued for the essential oil (EO) extracted from its heartwood. In this study, we present a high-quality chromosome-level genome assembly...
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Open AccessEffects of three orthodontic retainers on periodontal pathogens and periodontal parameters
The objective of this study was to compare and evaluate the changes in periodontal pathogens and periodontal status within 6 months of wearing three orthodontic retainers, namely, vacuum-formed retainer (VFR),...
