42 Result(s)

Article

Early-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants

Stroke is a life-threatening condition that causes a major medical burden globally. The currently used methods for the prevention or prediction of stroke have certain limitations. Exposure to tobacco in early ...

Fabin Lin, Xuanjie Chen, Yisen Shi, Kaitai Yang, Guo** Hu… in BMC Public Health (2024)

Article

Myricetin alleviates diabetic cardiomyopathy by regulating gut microbiota and their metabolites

The gut microbiota is involved in the pathogenesis of diabetic cardiomyopathy (DCM). Myricetin protects cardiac function in DCM. However, the low bioavailability of myricetin fails to explain its pharmacologic...

**xiu Zhu, Zhijun Bao, Zuoqi Hu, Shenglin Wu, Cuihong Tian… in Nutrition & Diabetes (2024)

Article

Development and preliminary evaluation of the Comprehensive Health Self-Assessment Questionnaire (CHSAQ) for individuals in the Chinese People Liberation Army

There is currently no widely accepted multidimensional health assessment questionnaire for individuals in the Chinese People Liberation Army (PLA). This study developed a multidimensional health survey questio...

Tao Wang, Han Tang, **nrui Li, Lin Wu, Ning Li, Wei Zhang… in BMC Public Health (2024)

Article

Sequencing of cerebrospinal fluid cell-free DNA facilitated early differential diagnosis of intramedullary spinal cord tumors

Pre-surgery differential diagnosis is valuable for personalized treatment planning in intramedullary spinal cord tumors. This study assessed the performance of sequencing cell-free DNA (cfDNA) in cerebrospinal...

Ruichao Chai, Songyuan An, Han Lin, Bo Pang, Hao Yan, Yun Liu… in npj Precision Oncology (2024)

Article

Bispecific CS1-BCMA CAR-T cells are clinically active in relapsed or refractory multiple myeloma

Multiple myeloma (MM) bears heterogeneous cells that poses a challenge for single-target immunotherapies. Here we constructed bispecific CS1-BCMA CAR-T cells aiming to augment BCMA targeting with CS1. Sixteen ...

Chenggong Li, Jia Xu, Wen**g Luo, Danying Liao, Wei **e, Qiuzhe Wei… in Leukemia (2024)

Article

The predictive value of machine learning for mortality risk in patients with acute coronary syndromes: a systematic review and meta-analysis

Acute coronary syndromes (ACS) are the leading cause of global death. Optimizing mortality risk prediction and early identification of high-risk patients is essential for develo** targeted prevention strateg...

**aoxiao Zhang, ** Wang, Luxin Xu, Jia Liu… in European Journal of Medical Research (2023)

Article

Efficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial

This phase I/II trial characterized the tolerability, safety, and antitumor activities of unecritinib, a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1, ALK, and c-MET, in ...

Shun Lu, Hongming Pan, Lin Wu, Yu Yao… in Signal Transduction and Targeted Therapy (2023)

Article

Black-White Risk Differentials in Pediatric COVID-19 Hospitalization and Intensive Care Unit Admissions in the USA

The COVID-19 morbidity with SARS-CoV-2 as a causative pathogenic microbe remains a pandemic with children experiencing less mortality but with severe manifestations. The current study aimed to assess SARS-CoV-...

Laurens Holmes Jr., Colin Wu, Rakinya Hinson… in Journal of Racial and Ethnic Health Dispar… (2023)

Article

Central nervous system efficacy of furmonertinib (AST2818) in patients with EGFR T790M mutated non-small cell lung cancer: a pooled analysis from two phase 2 studies

Furmonertinib (AST2818) is a brain penetrant pan-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting both EGFR sensitizing mutations and T790M mutation. We report the pooled central ...

**ngsheng Hu, Shucai Zhang, Zhiyong Ma, Jifeng Feng, Lin Wu, Dongqing Lv… in BMC Medicine (2023)

Article

The phenotype and prediction of long-term physical, mental and cognitive COVID-19 sequelae 20 months after recovery, a community-based cohort study in China

Long-term sequelae clustering phenotypes are important for precise health care management in COVID-19 survivors. We reported findings for 1000 survivors 20 months after diagnosis of COVID-19 in a community-bas...

Yimiao Zhao, Le Shi, Zhendong Jiang, Na Zeng, Huan Mei, Yu Lu… in Molecular Psychiatry (2023)

Article

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout...

Yan-Lin Wu, Zheng-Jun Lin, Chang-Chun Li… in Signal Transduction and Targeted Therapy (2023)

Article

Impact of job demands on police stress response—the roles of basic psychological needs and job autonomy

Police officers are a high-stress group with special job characteristics, and the Chinese police management system places particularly high demands on police officers. Whether the influence of job demands on o...

Pei-feng Chen, Lin Wu in BMC Public Health (2022)

Article

Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort

Though the association between air pollution and incident type 2 diabetes (T2D) has been well documented, evidence on the association with development of subsequent diabetes complications and post-diabetes mor...

Yinglin Wu, Shiyu Zhang, Samantha E. Qian, Miao Cai, Haitao Li… in BMC Medicine (2022)

Article

Effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines against SARS-CoV-2 Omicron BA. 2 variant infection, severe illness, and death

Limited data are available on the effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines in real-world use—especially against Omicron variants in SARS-CoV-2 infection-naïve population.

Zhuoying Huang, Shuangfei Xu, Jiechen Liu, Linlin Wu, **g Qiu, Nan Wang… in BMC Medicine (2022)

Article

Induction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis

Despite limited efficacy of immunotherapy for advanced non-small-cell lung cancer (NSCLC) with driver mutations, whether neoadjuvant immunotherapy could be clinically valuable in those patients warrants furthe...

Chao Zhang, Hua-Fei Chen, Shi Yan, Lin Wu, Li-Xu Yan… in npj Precision Oncology (2022)

Article

Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response

Cancers are highly complex diseases that are characterized by not only the overgrowth of malignant cells but also an altered immune response. The inhibition and reprogramming of the immune system play critical...

Dong-Rui Wang, **an-Lin Wu, Ying-Li Sun in Signal Transduction and Targeted Therapy (2022)

Article

Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation

Coronary atherosclerosis (CA) is the most common type of atherosclerosis. However, the inherent pathogenesis and mechanisms of CA are unclear, and the relationship with ferroptosis-related genes (FRGs) has not...

Qingwen Meng, Yiqian Xu, Xuebin ling, Huajiang Liu… in BMC Cardiovascular Disorders (2022)

Article

Correction to: USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis

Aihui Ma, Ming Tang, Li Zhang, Boshi Wang, Zhaojuan Yang, Yun Liu, Guiqin Xu… in Oncogene (2022)

Article

Risk/benefit tradeoff of habitual physical activity and air pollution on chronic pulmonary obstructive disease: findings from a large prospective cohort study

The combined health impact of physical activity (PA) and air pollution on chronic obstructive pulmonary disease (COPD) remains unclear. We investigated the joint effects of habitual PA and long-term fine parti...

Lan Chen, Miao Cai, Haitao Li, **aojie Wang, Fei Tian, Yinglin Wu… in BMC Medicine (2022)

Article

Correction to: Correlation between Wall Shear Stress and Acute Degradation of the Endothelial Glycocalyx during Cardiopulmonary Bypass

A Correction to this paper has been published: https://doi.org/10.1007/s12265-021-10145-5

Guoliang He, Yuan Gao, Linya Feng… in Journal of Cardiovascular Translational Re… (2022)