85 Result(s)
within
Article
**lin Wu
Medicine & Public Health
Medicine/Public Health, general
-
Article
Open AccessEarly-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants
Stroke is a life-threatening condition that causes a major medical burden globally. The currently used methods for the prevention or prediction of stroke have certain limitations. Exposure to tobacco in early ...
-
Article
Acetylcholine muscarinic M1 receptors in the rodent prefrontal cortex modulate cognitive abilities to establish social hierarchy
In most social species, the attainment of social dominance is strongly affected by personality traits. Dominant individuals show better cognitive abilities, however, whether an individual’s cognition can deter...
-
Article
Associations of slee** patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults
Studies have found a U-shaped relationship between sleep duration and chronic kidney disease (CKD) risk, but limited research evaluated the association of reallocating excessive sleep to other behavior with CK...
-
Article
Exploring Cutting-Edge Approaches to Potentiate Mesenchymal Stem Cell and Exosome Therapy for Myocardial Infarction
Cardiovascular diseases (CVDs) continue to be a significant global health concern. Many studies have reported promising outcomes from using MSCs and their secreted exosomes in managing various cardiovascular-r...
-
Article
Anesthesia, Anesthetics, and Postoperative Cognitive Dysfunction in Elderly Patients
Postoperative cognitive dysfunction (POCD) remains a major issue that worsens the prognosis of elderly surgery patients. This article reviews the current research on the effect of different anesthesia methods ...
-
Article
Open AccessMyricetin alleviates diabetic cardiomyopathy by regulating gut microbiota and their metabolites
The gut microbiota is involved in the pathogenesis of diabetic cardiomyopathy (DCM). Myricetin protects cardiac function in DCM. However, the low bioavailability of myricetin fails to explain its pharmacologic...
-
Article
Open AccessDevelopment and preliminary evaluation of the Comprehensive Health Self-Assessment Questionnaire (CHSAQ) for individuals in the Chinese People Liberation Army
There is currently no widely accepted multidimensional health assessment questionnaire for individuals in the Chinese People Liberation Army (PLA). This study developed a multidimensional health survey questio...
-
Article
Open AccessSequencing of cerebrospinal fluid cell-free DNA facilitated early differential diagnosis of intramedullary spinal cord tumors
Pre-surgery differential diagnosis is valuable for personalized treatment planning in intramedullary spinal cord tumors. This study assessed the performance of sequencing cell-free DNA (cfDNA) in cerebrospinal...
-
Article
Open AccessBispecific CS1-BCMA CAR-T cells are clinically active in relapsed or refractory multiple myeloma
Multiple myeloma (MM) bears heterogeneous cells that poses a challenge for single-target immunotherapies. Here we constructed bispecific CS1-BCMA CAR-T cells aiming to augment BCMA targeting with CS1. Sixteen ...
-
Article
Effects of rapeseed oil on body composition and glucolipid metabolism in people with obesity and overweight: a systematic review and meta-analysis
To investigate the effects of rapeseed oil on body composition, blood glucose and lipid metabolism in people with overweight and obesity compared to other cooking oils. We searched eight databases for randomiz...
-
Article
Easykin: a flexible and user-friendly online tool for forensic kinship testing and missing person identification
In forensic kinship testing and missing person identification, it is a fundamental question to choose the most informative reference relatives, select appropriate genoty** systems, and evaluate the weight of...
-
Article
More moderate-intensity physical activity and less prolonged sedentary time are associated with better very short-term systolic blood pressure variability in healthy adults
Whole-day movement guidelines for improving health, recommend that adults engage in at least 150 min week−1 of moderate-to-vigorous aerobic physical activity and limit their sedentary time. In young adults, highe...
-
Article
Open AccessThe predictive value of machine learning for mortality risk in patients with acute coronary syndromes: a systematic review and meta-analysis
Acute coronary syndromes (ACS) are the leading cause of global death. Optimizing mortality risk prediction and early identification of high-risk patients is essential for develo** targeted prevention strateg...
-
Article
Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update
The increasing number of coronavirus disease 2019 (COVID-19) infections have highlighted the long-term consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection called long COVID. ...
-
Article
Open AccessEfficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial
This phase I/II trial characterized the tolerability, safety, and antitumor activities of unecritinib, a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1, ALK, and c-MET, in ...
-
Article
Black-White Risk Differentials in Pediatric COVID-19 Hospitalization and Intensive Care Unit Admissions in the USA
The COVID-19 morbidity with SARS-CoV-2 as a causative pathogenic microbe remains a pandemic with children experiencing less mortality but with severe manifestations. The current study aimed to assess SARS-CoV-...
-
Article
Open AccessCentral nervous system efficacy of furmonertinib (AST2818) in patients with EGFR T790M mutated non-small cell lung cancer: a pooled analysis from two phase 2 studies
Furmonertinib (AST2818) is a brain penetrant pan-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting both EGFR sensitizing mutations and T790M mutation. We report the pooled central ...
-
Article
The phenotype and prediction of long-term physical, mental and cognitive COVID-19 sequelae 20 months after recovery, a community-based cohort study in China
Long-term sequelae clustering phenotypes are important for precise health care management in COVID-19 survivors. We reported findings for 1000 survivors 20 months after diagnosis of COVID-19 in a community-bas...
-
Article
Open AccessEpigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout...
-
Article
Open AccessImpact of job demands on police stress response—the roles of basic psychological needs and job autonomy
Police officers are a high-stress group with special job characteristics, and the Chinese police management system places particularly high demands on police officers. Whether the influence of job demands on o...
