80 Result(s)
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English
Life Sciences
Life Sciences, general
**lin Wu
Article
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Article
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance
Endocrine therapy that blocks estrogen signaling is the most effective treatment for patients with estrogen receptor positive (ER+) breast cancer. However, the efficacy of agents such as tamoxifen (Tam) is often ...
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Open AccessCXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity
The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that d...
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Open AccessAntibiotic-induced microbiome depletion promotes intestinal colonization by Campylobacter jejuni in mice
To establish a method to induce Campylobacter jejuni colonization in the intestines of C57BL/6 mice through antibiotic-induced microbiome depletion.
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Open AccessRAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair
RAD18, an important ubiquitin E3 ligase, plays a dual role in translesion DNA synthesis (TLS) and homologous recombination (HR) repair. However, whether and how the regulatory mechanism of O-linked N-acetylglu...
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Open AccessTranscriptomic study of the role of MeFtsZ2-1 in pigment accumulation in cassava leaves
MeFtsZ2-1 is a key gene for plant plastid division, but the mechanism by which MeFtsZ2-1 affects pigment accumulation in cassava (Manihot esculenta Crantz) through plastids remains unclear. We found that MeFtsZ2-...
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Complicated target recognition by archaeal box C/D guide RNAs
Box C/D RNAs guide the site-specific formation of 2′-O-methylated nucleotides (Nm) of RNAs in eukaryotes and archaea. Although C/D RNAs have been profiled in several archaea, their targets have not been experimen...
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Open AccessCharacterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a molecularly heterogeneous solid malignancy, and its fitness may be shaped by how its tumor cells evolve. However, ability to monitor tumor cell evolution is hampered by the ...
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Open AccessKCTD15 acts as an anti-tumor factor in colorectal cancer cells downstream of the demethylase FTO and the m6A reader YTHDF2
Potassium Channel Tetramerization Domain Containing 15 (KCTD15) participates in the carcinogenesis of several solid malignancies; however, its role in colorectal cancer (CRC) remains unclear. Here we find that...
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Open AccessEvaluation of a novel lysis-based sample processing method to optimize Vibrio vulnificus detecting by loop-mediated isothermal amplification assay
Vibrio vulnificus exists as one of the most serious foodborne pathogens for humans, and rapid and sensitive detection methods are needed to control its infections. As an emerging method, The Loop-Mediated Isother...
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Open AccessEpigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses
Eukaryotic five-methylcytosine (m5C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown. In this study, functional m5C sites ...
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Open AccessCharacterizing immune variation and diagnostic indicators of preeclampsia by single-cell RNA sequencing and machine learning
Preeclampsia is a multifactorial and heterogeneous complication of pregnancy. Here, we utilize single-cell RNA sequencing to dissect the involvement of circulating immune cells in preeclampsia. Our findings re...
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Open AccessCerebral endothelial cell-derived extracellular vesicles regulate microglial polarization and promote autophagy via delivery of miR-672-5p
The interaction between cerebral endothelial cells (CEC) and brain parenchymal cells is critical to maintain neurovascular homeostasis, whereas extracellular vesicles (EVs) are essential to mediate the cell–ce...
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Open AccessIntegrated analyses of metabolomics and transcriptomics reveal the potential regulatory roles of long non-coding RNAs in gingerol biosynthesis
As the characteristic functional component in ginger, gingerols possess several health-promoting properties. Long non-coding RNAs (lncRNAs) act as crucial regulators of diverse biological processes. However, l...
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Open AccessFOXM1 maintains fatty acid homoeostasis through the SET7-H3K4me1-FASN axis
Reprogramming of metabolic genes and subsequent alterations in metabolic phenotypes occur widely in malignant tumours, including glioblastoma (GBM). FOXM1 is a potent transcription factor that plays an oncogen...
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Open AccessRecent advances of natural pigments from algae
Pigment is an important food additive that plays a major role in the sensory impact of food. And natural sources, healthy and non-toxic edible pigments are receiving a lot of attention. Algae is an important s...
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In vitro plant regeneration from callus cultures induced from seeds of Hedychium forrestii Diels
Hedychium forrestii Diels is a ginger plant with high ornamental and economic value. An efficient regeneration protocol was established with seeds as explants. Callus was induced on Murashige and Skoog (MS) mediu...
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Open AccessGenome-wide identification and expression analysis of the cyclic nucleotide-gated ion channel (CNGC) gene family in Saccharum spontaneum
Cyclic nucleotide-gated ion channels (CNGCs) are nonselective cation channels that are ubiquitous in eukaryotic organisms. As Ca2+ channels, some CNGCs have also proven to be K+-permeable and involved in plant de...
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Open AccessFGF21-FGFR1 controls mitochondrial homeostasis in cardiomyocytes by modulating the degradation of OPA1
Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone secreted primarily by the liver and is considered a major regulator of energy homeostasis. Recent research has revealed that FGF21 could play an imp...
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Open AccessRab32 promotes glioblastoma migration and invasion via regulation of ERK/Drp1-mediated mitochondrial fission
The highly widespread and infiltrative nature of glioblastoma multiforme (GBM) makes complete surgical resection hard, causing high recurrence rate and poor patients’ prognosis. However, the mechanism underlyi...
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Open AccessCharacterization and expression profiles of the B-box gene family during plant growth and under low-nitrogen stress in Saccharum
B-box (BBX) zinc-finger transcription factors play crucial roles in plant growth, development, and abiotic stress responses. Nevertheless, little information is available on sugarcane (Saccharum spp.) BBX genes a...
