311 Result(s)

Article

Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediate-grade primary breast cancer

The histological manifestation of growth-regulating and differentiation-inducing signals in cancer cells is considered as a key component for clinical outcome prediction and commonly defined as tumor different...

A Sayeed, Z Meng, G Luciani, L-C Chen, J L Bennington, S H Dairkee in Cell Death & Disease (2010)

Article

ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network

HeLa cells treated with celastrol, a natural compound with inhibitive effect on proteasome, exhibited increase in apoptotic rate and characteristics of apoptosis. To clarify the signal network activated by cel...

L Feng, D Zhang, C Fan, C Ma, W Yang, Y Meng, W Wu, S Guan, B Jiang… in Cell Death & Disease (2013)

Article

Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells

Stem cells were characterized by their stemness: self-renewal and pluripotency. Mesenchymal stem cells (MSCs) are a unique type of adult stem cells that have been proven to be involved in tissue repair, immuno...

J Hou, Z-p Han, Y-y **g, X Yang, S-s Zhang, K Sun, C Hao, Y Meng… in Cell Death & Disease (2013)

Article

Cancer-initiating cells derived from human rectal adenocarcinoma tissues carry mesenchymal phenotypes and resist drug therapies

Accumulating evidence indicates that cancer-initiating cells (CICs) are responsible for cancer initiation, relapse, and metastasis. Colorectal carcinoma (CRC) is typically classified into proximal colon, dista...

C-W Fan, T Chen, Y-N Shang, Y-Z Gu, S-L Zhang, R Lu, S-R OuYang… in Cell Death & Disease (2013)

Article

Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish

Hearing loss is a serious burden to physical and mental health worldwide. Aberrant development and damage of hearing organs are recognized as the causes of hearing loss, the molecular mechanisms underlining th...

Z-y Hu, Q-y Zhang, W Qin, J-w Tong, Q Zhao, Y Han, J Meng… in Cell Death & Disease (2013)

Article

Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation

Cultured human umbilical cord mesenchymal stem cells (hUC-MSCs) are being tested in several clinical trials and encouraging outcomes have been observed. To determine whether in vitro expansion influences the geno...

Y Wang, Z Zhang, Y Chi, Q Zhang, F Xu, Z Yang, L Meng, S Yang… in Cell Death & Disease (2013)

Article

Knockdown of BAG3 induces epithelial–mesenchymal transition in thyroid cancer cells through ZEB1 activation

The process by which epithelial features are lost in favor of a mesenchymal phenotype is referred to as epithelial–mesenchymal transition (EMT). Most carcinomas use this mechanism to evade into neighboring tis...

X Meng, D-H Kong, N Li, Z-H Zong, B-Q Liu, Z-X Du, Y Guan, L Cao… in Cell Death & Disease (2014)

Article

Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor

Methamphetamine (METH) is a psychostimulant with high abuse potential and severe neurotoxicity. Recent studies in animal models have indicated that METH can impair the blood–brain barrier (BBB), suggesting tha...

J Ma, J Wan, J Meng, S Banerjee, S Ramakrishnan, S Roy in Cell Death & Disease (2014)

Article

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, ...

J-S Zhang, M Herreros-Villanueva, A Koenig, Z Deng… in Cell Death & Disease (2014)

Article

CREAM: a database for chemotherapy resistance-associated miRSNP

E Dai, Y Lv, F Meng, X Yu, Y Zhang, S Wang, X Liu, D Liu, J Wang… in Cell Death & Disease (2014)

Article

Erratum: Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

Correction to: Cell Death and Disease (2014) 5, e1142; doi:10.1038/cddis.2014.102; published online 27 March 2014 Since the publication of this paper it has been noted that M Herreros-Villanueva’s name was mis...

J-S Zhang, M Herreros-Villanueva, A Koenig, Z Deng… in Cell Death & Disease (2014)

Article

Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy?

Classically, as a transcription factor family, the E2Fs are known to regulate the expression of various genes whose products are involved in a multitude of biological functions, many of which are deregulated i...

P Meng, R Ghosh in Cell Death & Disease (2014)

Article

CD4⁺Foxp3⁺ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions

Endometriosis is associated with an abnormal immune response to endometrial cells, which can facilitate the implantation and proliferation of ectopic endometrial tissue. The proportion of CD4⁺Foxp3⁺ regulatory T ...

M-Q Li, Y Wang, K-K Chang, Y-H Meng, L-B Liu, J Mei, Y Wang… in Cell Death & Disease (2014)

Article

Inhibition of human positive cofactor 4 radiosensitizes human esophageal squmaous cell carcinoma cells by suppressing XLF-mediated nonhomologous end joining

Radiotherapy has the widest application to esophageal squamous cell carcinoma (ESCC) patients. Factors associated with DNA damage repair have been shown to function in cell radiosensitivity. Human positive cof...

D Qian, B Zhang, X-L Zeng, J M Le Blanc, Y-H Guo, C Xue, C Jiang… in Cell Death & Disease (2014)

Article

c-Met and CREB1 are involved in miR-433-mediated inhibition of the epithelial–mesenchymal transition in bladder cancer by regulating Akt/GSK-3β/Snail signaling

Emerging evidence has suggested that microRNAs (miRNAs) have an important role in tumor development and progression by regulating diverse cellular pathways. Here we describe the function and regulation network...

X Xu, Y Zhu, Z Liang, S Li, X Xu, X Wang, J Wu, Z Hu, S Meng, B liu… in Cell Death & Disease (2016)

Article

DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity

EZH2 is a histone methyltransferase whose functions in stem cells and tumor cells are well established. Accumulating evidence shows that EZH2 has critical roles in T cells and could be a promising therapeutic ...

Y Wang, H Sun, J Wang, H Wang, L Meng, C Xu, M **, B Wang, Y Zhang… in Cell Death & Disease (2016)

Article

Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a potent cancer cell-specific apoptosis-inducing cytokine with little toxicity to most normal cells. However, acquired resistance of can...

Lei Chen, Yue Meng, Qi Sun, Zhongyu Zhang, **aoqing Guo… in Cell Death & Disease (2016)

Article

P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy

Aberrant autophagic processes have been found to have fundamental roles in the pathogenesis of different kinds of tumors, including hepatocellular carcinoma (HCC). P300/CBP-associated factor (PCAF), a histone ...

Yu-Li Jia, Meng Xu, Chang-Wei Dou, Zhi-Kui Liu, Yu-Mo Xue… in Cell Death & Disease (2016)

Article

CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis

Abnormal expression of cyclin-dependent kinase 5 (CDK5) has been found in several human cancers, whereas the role of CDK5 in the malignant development of colorectal cancer (CRC) has not been well characterized...

Kangmin Zhuang, Juchang Zhang, Man **ong, **anfei Wang, **aobei Luo… in Cell Death & Disease (2016)

Article

Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats

Increasing evidence indicates that sirtuin 1 (SIRT1) is implicated in a wide range of cellular functions, such as oxidative stress, inflammation and apoptosis. The aim of this study was to investigate the chan...

**ang-Sheng Zhang, Qi Wu, Ling-Yun Wu, Zhen-Nan Ye, Tian-Wei Jiang… in Cell Death & Disease (2016)