55 Result(s)

Article

Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Broad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human patients with cancer whose tumours are driven by RAS mutations^1,2. RMC-7977 is a highly selective inhibitor of the active GTP-...

Urszula N. Wasko, **g**g Jiang, Tanner C. Dalton, Alvaro Curiel-Garcia… in Nature (2024)

Article

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

RAS oncogenes (collectively NRAS, HRAS and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 61¹. Small molecule inhibitors of the...

Matthew Holderfield, Bianca J. Lee, **g**g Jiang, Aidan Tomlinson… in Nature (2024)

Article

Improvement of roughness in ultrasonic assisted magnetorheological finishing of small titanium alloy nuts by orthogonal test method

Titanium alloy with high corrosion resistance, high strength-to-density ratio, and excellent biocompatibility has a wide range of applications in the field of biomedical implants. Polishing experiments of tita...

Cheng Bi, Axiang Ji, Hongyun Wang, Haibo Wang, Junhua Zhu… in Scientific Reports (2024)

Article

Author Correction: Carbene-catalyzed chemoselective reaction of unsymmetric enedials for access to Furo[2,3-b]pyrroles

Guodong Fan, Qingyun Wang, Jun Xu, Pengcheng Zheng… in Nature Communications (2024)

Article

Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma

The poorly differentiated thyroid carcinoma (THCA) subtype is associated with an aggressive disease course, a less favorable overall prognosis, and an increased risk of distant organ metastasis. In this study,...

**aowei Zhang, **angwei Meng, Pengyun Wang, Chong Luan, Haiming Wang in Scientific Reports (2024)

Article

Magnetic circuit design for the performance experiment of shear yield stress enhanced by compression of magnetorheological fluids

The shear yield stress is an important parameter for the industrial application of magnetorheological (MR) fluids. A test equipment was designed and built to perform investigations on the behaviours of compres...

Cheng Bi, Erda Bi, Hongyun Wang, Chunlin Deng, Huixin Chen, Yun Wang in Scientific Reports (2024)

Article

NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release

A carbene-catalyzed asymmetric access to chiral β-cyano carboxylic esters is disclosed. The reaction proceeds between β,β-disubstituted enals and aromatic thiols involving enantioselective protonation of enal ...

Qingyun Wang, Shuquan Wu, Juan Zou, Xuyang Liang, Chengli Mou… in Nature Communications (2023)

Article

Carbene-catalyzed chemoselective reaction of unsymmetric enedials for access to Furo[2,3-b]pyrroles

A carbene-catalyzed chemoselective reaction of unsymmetric enedials is disclosed. The reaction provides a concise access to bicyclic furo[2,3-b]pyrroles derivatives in excellent selectivity. A main challenge i...

Guodong Fan, Qingyun Wang, Jun Xu, Pengcheng Zheng… in Nature Communications (2023)

Article

Identification of the SARS-unique domain of SARS-CoV-2 as an antiviral target

SARS-CoV-2 nsp3 is essential for viral replication and host responses. The SARS-unique domain (SUD) of nsp3 exerts its function through binding to viral and host proteins and RNAs. Herein, we show that SARS-Co...

Bo Qin, Ziheng Li, Kaiming Tang, Tongyun Wang, Yubin **e… in Nature Communications (2023)

Article

CZK, a novel alkaloid derivative from Clausena lansium, alleviates ischemic stroke injury through Nrf2-mediated antioxidant effects

Anti-oxidant stress is a potential strategy for the treatment of ischemic stroke. Here, we found a novel free radical scavenger termed as CZK, which is derived from alkaloids contained in Clausena lansium. In thi...

Haodong Chen, Yangbo Liu, Juling Feng, Hongyun Wang, Yantao Yang… in Scientific Reports (2023)

Article

Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens

CreTA, CRISPR-regulated toxin-antitoxin (TA), safeguards CRISPR-Cas immune systems by inducing cell dormancy/death upon their inactivation. Here, we characterize a bacterial CreTA associating with the I-F CRIS...

Rui Wang, **an Shu, Huiwei Zhao, Qiong Xue, Chao Liu, Aici Wu… in Nature Communications (2023)

Article

Natural oxidase-mimicking copper-organic frameworks for targeted identification of ascorbate in sensitive sweat sensing

Sweat sensors play a significant role in personalized healthcare by dynamically monitoring biochemical markers to detect individual physiological status. The specific response to the target biomolecules usuall...

Zhengyun Wang, Yuchen Huang, Kunqi Xu, Yanyu Zhong, Chaohui He… in Nature Communications (2023)

Article

Reduced neural responses to reward reflect anhedonia and inattention: an ERP study

An inhibited neural response to reward is typical of clinical depression and can predict an individual's overall depressive symptoms. However, the mechanism underlying this are unclear. Previous studies have f...

Zhengjie Liu, Mengyun Wang, **aojuan Zhou, Shubao Qin, Ziyang Zeng… in Scientific Reports (2022)

Article

Study of a Si-based light initiated multi-gate semiconductor switch for high temperatures

Light initiated multi-gate semiconductor switch (LIMS) is a kind of power electronic device which has many differences from traditional thyristor triggered by electric pulse. LIMS is triggered by laser, the tu...

Chongbiao Luan, Hongwei Liu, Jiabin Fu, Yang He, Le Xu, Lingyun Wang… in Scientific Reports (2022)

Article

Transient behavior of compressed magnetorheological brake excited by step currents

Transient behavior of a magnetorheological brake excited by step currents under compression-shear mode has been experimentally studied. The results show that the amplitude of the applied current had little eff...

Hongyun Wang, Cheng Bi, Yongju Zhang, Axiang Ji, Pengyuan Qiu in Scientific Reports (2021)

Article

Compressions of magnetorheological fluids under instantaneous magnetic field and constant area

Compressions of magnetorheological (MR) fluids have been carried out under instantaneous magnetic fields. The yield strength of the MR fluid in compressive mode has been derived by assuming that it was a trans...

Hongyun Wang, Cheng Bi, Yongju Zhang, Li Zhang, Fenfen Zhou in Scientific Reports (2021)

Article

Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2

Arrestins recognize different receptor phosphorylation patterns and convert this information to selective arrestin functions to expand the functional diversity of the G protein-coupled receptor (GPCR) superfam...

Qing-Tao He, Peng **ao, Shen-Ming Huang, Ying-Li Jia… in Nature Communications (2021)

Article

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allos...

Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez… in Scientific Reports (2021)

Article

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl ¹H-NMR probe

Characterization of the dynamic conformational changes in membrane protein signaling complexes by nuclear magnetic resonance (NMR) spectroscopy remains challenging. Here we report the site-specific incorporati...

Qi Liu, Qing-tao He, **aoxuan Lyu, Fan Yang, Zhong-liang Zhu… in Nature Communications (2020)

Article

Comparison of gut microbiota in exclusively breast-fed and formula-fed babies: a study of 91 term infants

To compare gut microbiota of healthy infants that were exclusively breast-fed or formula-fed, we recruited 91 infants, who were assigned into three different groups and fed by breast milk (30 babies), formula ...

**gran Ma, Zhenghong Li, Wenjuan Zhang, Chunli Zhang, Yuheng Zhang… in Scientific Reports (2020)