66 Result(s)
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Article
**gYun Wang
Biomedicine
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Open AccessFunctional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients
Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic ...
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Open AccessRetraction Note: LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis
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Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis
Pyroptosis is an inflammatory programmed cell death (PCD) and is reported to be associated with N6-methyladenosine (m6A) modification. This study aimed to investigate the mechanism of m6A demethylase AlkB homo...
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Galectin-3 Mediates Endotoxin Internalization and Caspase-4/11 Activation in Tubular Epithelials and Macrophages During Sepsis and Sepsis-Associated Acute Kidney Injury
Besides being recognized by membrane receptor TLR4, lipopolysaccharide (LPS) can also be internalized into the cytosol and activate Caspase-4/11 pyroptotic pathways to further amplify inflammation in sepsis. T...
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Prevalence and sequence diversity of Balantioides coli in pigs in **njiang, China
Balantioides coli is a common intestinal parasitic protozoan in pigs. In the present study, 801 fecal samples of pigs from seven farms in **njiang were analyzed based on the ITS1-5.8S rRNA-ITS2 gene. The prevale...
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Silymarin ameliorates peritoneal fibrosis by inhibiting the TGF-β/Smad signaling pathway
Peritoneal dialysis (PD) is the mainstay of treatment for renal failure replacement therapy. Although PD has greatly improved the quality of life of end-stage renal disease (ESRD) patients, long-term PD can le...
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Preface for special issue on nonlinear dynamics modeling and control for brain science and brain-like intelligence
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A computational network dynamical modeling for abnormal oscillation and deep brain stimulation control of obsessive–compulsive disorder
Obsessive–compulsive disorder (OCD) is associated with multi-nodal abnormalities in brain networks, characterized by recurrent intrusive thoughts (obsessions) and repetitive behaviours or mental acts (compulsi...
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Open AccessBNIP3 as a potential biomarker for the identification of prognosis and diagnosis in solid tumours
Traditional radiotherapy and chemotherapy have been intensively studied for their role in the treatment of tumours. However, these therapies often cause side effects for patients, which calls for the developme...
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A biophysical model for dopamine modulating working memory through reward system in obsessive–compulsive disorder
Dopamine modulates working memory in the prefrontal cortex (PFC) and is crucial for obsessive–compulsive disorder (OCD). However, the mechanism is unclear. Here we establish a biophysical model of the effect o...
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The role of inflammatory biomarkers in the association between rheumatoid arthritis and depression: a Mendelian randomization study
Inflammation may mediate the co-pathogenesis of rheumatoid arthritis (RA) and depression because inflammatory cytokines are associated with RA and depression. However, traditional observational research was no...
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Open AccessStrong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa
Pseudomonas aeruginosa (PA) is a leading cause of hospital-acquired and ventilator-associated pneumonia. The multidrug-resistance (MDR) rate of PA is increasing making the management of PA a global challenge. Mes...
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CISD2 Promotes Proliferation of Colorectal Cancer Cells by Inhibiting Autophagy in a Wnt/β-Catenin-Signaling-Dependent Pathway
The aim of this study is to investigate the role of CDGSH iron-sulfur domain 2 (CISD2) in colorectal cancer (CRC). The purpose of this study was to investigate the role of CDGSH iron-sulfur domain 2 (CISD2) in...
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Open AccessRisk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations
The genetic architectures of colorectal cancer are distinct across different populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR) populations, which limits their a...
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Open AccessDimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress
Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) pollution is associated with the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary dise...
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Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy
Glomerular mesangial cell proliferation and extracellular matrix accumulation contribute to the progression of diabetic nephropathy (DN). As a conserved stress-inducible protein, sestrin2 (Sesn2) plays critica...
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Open AccessSingle-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells
Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical f...
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Model-based optogenetic stimulation to regulate beta oscillations in Parkinsonian neural networks
Optogenetic stimulation, an effective stimulation technique, is applied to the treatment of Parkinson’s disease (PD) to compete with the current neuromodulation technology that focuses on the electrical stimul...
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Revealing the Modular Similarities and Differences Among Alzheimer’s Disease, Vascular Dementia, and Parkinson’s Disease in Genomic Networks
Alzheimer’s disease (AD), vascular dementia (VD), and Parkinson’s disease (PD) exert increasingly lethal or disabling effects on humans, but the associations among these diseases at the molecular level remain ...
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Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
Tumor-associated macrophages are composed of distinct populations arising from monocytes or tissue macrophages, with a poorly understood link to disease pathogenesis. Here, we demonstrate that mouse monocyte m...
