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The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168

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  1. Article

    Open Access

    Evaluation of islets derived from human fetal pancreatic progenitor cells in diabetes treatment

    With the shortage of donor organs for islet transplantation, insulin-producing cells have been generated from different types of stem cell. Human fetal pancreatic stem cells have a better self-renewal capacity...

    Wen-Jian Zhang, Shi-Qing Xu, Han-Qing Cai, **u-Li Men in Stem Cell Research & Therapy (2013)

  2. Article

    Open Access

    Acyclic retinoid induces differentiation and apoptosis of murine hepatic stem cells

    The therapeutic potential of acyclic retinoid (ACR), a synthetic retinoid, has been confirmed in experimental and clinical studies. Therapeutic targets include precancerous and cancer stem cells. As ACR is als...

    Hong-Bin Guan, Yun-Zhong Nie, Yun-Wen Zheng in Stem Cell Research & Therapy (2015)

  3. Article

    Open Access

    Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

    Anaphase-promoting complex/cyclosome/Cdh1 is a multi-subunit ubiquitin E3 ligase that drives M to G1 cell cycle progression through primarily earmarking various substrates for ubiquitination and subsequent deg...

    Jia Liu, Lixin Wan, **g Liu, Zhu Yuan, **fang Zhang, Jianfeng Guo in Cell Discovery (2016)

  4. Article

    Open Access

    Questions about NgAgo

    Shawn Burgess, Linzhao Cheng, Feng Gu, Junjiu Huang, Zhiwei Huang in Protein & Cell (2016)

  5. Article

    Open Access

    Erratum to: Questions about NgAgo

    Shawn Burgess, Linzhao Cheng, Feng Gu, Junjiu Huang, Zhiwei Huang in Protein & Cell (2017)

  6. Article

    Open Access

    Mass spectrometry based proteomics profiling of human monocytes

    Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehe...

    Yong Zeng, Fei-Yan Deng, Wei Zhu, Lan Zhang, Hao He, Chao Xu, Qing Tian in Protein & Cell (2017)

  7. Article

    Open Access

    Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity

    Triple-negative breast cancer (TNBC) remains a clinical challenge because of the absence of effective therapeutic targets. In TNBC, overexpression of YAP and TAZ correlates with bioactivities of cancer stem ce...

    Ying-Wei Li, Jian Xu, Guo-Yuan Zhu, Zhu-Juan Huang, Yan Lu in Cell Death Discovery (2018)

  8. Article

    Author Correction: Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2

    Since the publication of the article, the authors became aware that Figs. 1c, 5k and 6m contained errors in representative image and PAS score in control groups. The corrected Figs. 1c, 5k, and 6m are given be...

    Li-xia **a, Wen Hua, Yan **, Bao-** Tian, Zhang-wei Qiu in Cell Death & Differentiation (2019)

  9. Article

    Open Access

    Simulated microgravity significantly altered metabolism in epidermal stem cells

    Simulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia...

    Bin-Bin Li, Zheng-Yang Chen, Nan Jiang in In Vitro Cellular & Developmental Biology … (2020)

  10. Article

    Open Access

    Hypoxic preconditioning of human urine-derived stem cell-laden small intestinal submucosa enhances wound healing potential

    Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue r...

    **u-Ru Zhang, Yi-Zhou Huang, Hong-Wei Gao, Yan-Lin Jiang in Stem Cell Research & Therapy (2020)

  11. Article

    Correction to: Simulated microgravity significantly altered metabolism in epidermal stem cells

    The affiliation given for Yan Cui in this article is not correct. The following is the correction affiliation

    Bin-Bin Li, Zheng-Yang Chen, Nan Jiang in In Vitro Cellular & Developmental Biology … (2020)

  12. Article

    Open Access

    Gut microbiota patterns associated with somatostatin in patients undergoing pancreaticoduodenectomy: a prospective study

    Postoperative pancreatic fistula (POPF) is a common and dreaded complication after pancreaticoduodenectomy (PD). The gut microbiota has been considered as an crucial mediator of postoperative complications, ho...

    Guan-Qun Li, Tao Zhang, Wei-Guang Yang, Hao-Liang Zhong, Peng **ao in Cell Death Discovery (2020)

  13. Article

    Open Access

    Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the recent pandemic COVID-19, is reported to have originated from bats, with its intermediate host unknown to date. Here, we...

    Lili Wu, Qian Chen, Kefang Liu, Jia Wang, Pengcheng Han, Yanfang Zhang in Cell Discovery (2020)

  14. Article

    Open Access

    Correction: Gut microbiota patterns associated with somatostatin in patients undergoing pancreaticoduodenectomy: a prospective study

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Guan-Qun Li, Tao Zhang, Wei-Guang Yang, Hao-Liang Zhong, Peng **ao in Cell Death Discovery (2020)

  15. Article

    Open Access

    Light-sheet fluorescence imaging charts the gastrula origin of vascular endothelial cells in early zebrafish embryos

    It remains challenging to construct a complete cell lineage map of the origin of vascular endothelial cells in any vertebrate embryo. Here, we report the application of in toto light-sheet fluorescence imaging...

    Meijun Pang, Linlu Bai, Weijian Zong, Xu Wang, Ye Bu, in Cell Discovery (2020)

  16. Article

    Open Access

    Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants

    Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 3.8 million deaths to date. Neutralizing ...

    Jianhui Nie, **gshu **e, Shuo Liu, Jia**g Wu, Chuan Liu, Jianhui Li in Cell Discovery (2021)

  17. Article

    Open Access

    Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4

    Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-...

    Yu-Shui Ma, Ji-Bin Liu, Lan Lin, Hui Zhang, Jian-Jun Wu, Yi Shi in Cell Death Discovery (2021)

  18. Article

    Open Access

    Application of Bone Marrow Mesenchymal Stem Cells Effectively Eliminates Endotoxemia to Protect Rat from Acute Liver Failure Induced by Thioacetamide

    Endotoxemia is related to worse clinical outcomes in acute liver failure (ALF), but its management remains unsatisfactory. In this study, we aimed to assess whether the application of bone marrow mesenchymal s...

    Ting Jiang, Geng **a, Bo Yang in Tissue Engineering and Regenerative Medici… (2022)

  19. Article

    Open Access

    AR-regulated ZIC5 contributes to the aggressiveness of prostate cancer

    The mechanisms by which prostate cancer (PCa) progresses to the aggressive castration-resistant stage remain uncertain. Zinc finger of the cerebellum 5 (ZIC5), a transcription factor belonging to the ZIC famil...

    Yi-Fan Tan, Yang Zhang, Sheng-Yang Ge, Fan Zhong, Chuan-Yu Sun in Cell Death Discovery (2022)

  20. Article

    Open Access

    RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis

    Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor that has emerged as a prominent transcription repressing factor in carcinogenesis. However, the role of RUNX2 in brea...

    **n Yin, Xu Teng, Tianyu Ma, Tianshu Yang, **gyao Zhang in Cell Death & Differentiation (2022)

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