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Open AccessEvaluation of islets derived from human fetal pancreatic progenitor cells in diabetes treatment
With the shortage of donor organs for islet transplantation, insulin-producing cells have been generated from different types of stem cell. Human fetal pancreatic stem cells have a better self-renewal capacity...
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Open AccessAcyclic retinoid induces differentiation and apoptosis of murine hepatic stem cells
The therapeutic potential of acyclic retinoid (ACR), a synthetic retinoid, has been confirmed in experimental and clinical studies. Therapeutic targets include precancerous and cancer stem cells. As ACR is als...
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Open AccessCdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner
Anaphase-promoting complex/cyclosome/Cdh1 is a multi-subunit ubiquitin E3 ligase that drives M to G1 cell cycle progression through primarily earmarking various substrates for ubiquitination and subsequent deg...
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Open AccessQuestions about NgAgo
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Open AccessErratum to: Questions about NgAgo
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Open AccessMass spectrometry based proteomics profiling of human monocytes
Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehe...
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Open AccessApigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity
Triple-negative breast cancer (TNBC) remains a clinical challenge because of the absence of effective therapeutic targets. In TNBC, overexpression of YAP and TAZ correlates with bioactivities of cancer stem ce...
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Author Correction: Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2
Since the publication of the article, the authors became aware that Figs. 1c, 5k and 6m contained errors in representative image and PAS score in control groups. The corrected Figs. 1c, 5k, and 6m are given be...
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Open AccessSimulated microgravity significantly altered metabolism in epidermal stem cells
Simulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia...
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Open AccessHypoxic preconditioning of human urine-derived stem cell-laden small intestinal submucosa enhances wound healing potential
Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue r...
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Correction to: Simulated microgravity significantly altered metabolism in epidermal stem cells
The affiliation given for Yan Cui in this article is not correct. The following is the correction affiliation
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Open AccessGut microbiota patterns associated with somatostatin in patients undergoing pancreaticoduodenectomy: a prospective study
Postoperative pancreatic fistula (POPF) is a common and dreaded complication after pancreaticoduodenectomy (PD). The gut microbiota has been considered as an crucial mediator of postoperative complications, ho...
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Open AccessBroad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the recent pandemic COVID-19, is reported to have originated from bats, with its intermediate host unknown to date. Here, we...
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Open AccessCorrection: Gut microbiota patterns associated with somatostatin in patients undergoing pancreaticoduodenectomy: a prospective study
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessLight-sheet fluorescence imaging charts the gastrula origin of vascular endothelial cells in early zebrafish embryos
It remains challenging to construct a complete cell lineage map of the origin of vascular endothelial cells in any vertebrate embryo. Here, we report the application of in toto light-sheet fluorescence imaging...
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Open AccessThree epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants
Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 3.8 million deaths to date. Neutralizing ...
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Open AccessExosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4
Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-...
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Open AccessApplication of Bone Marrow Mesenchymal Stem Cells Effectively Eliminates Endotoxemia to Protect Rat from Acute Liver Failure Induced by Thioacetamide
Endotoxemia is related to worse clinical outcomes in acute liver failure (ALF), but its management remains unsatisfactory. In this study, we aimed to assess whether the application of bone marrow mesenchymal s...
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Open AccessAR-regulated ZIC5 contributes to the aggressiveness of prostate cancer
The mechanisms by which prostate cancer (PCa) progresses to the aggressive castration-resistant stage remain uncertain. Zinc finger of the cerebellum 5 (ZIC5), a transcription factor belonging to the ZIC famil...
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Open AccessRUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis
Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor that has emerged as a prominent transcription repressing factor in carcinogenesis. However, the role of RUNX2 in brea...