86 Result(s)

Article

Structural insights into drug transport by an aquaglyceroporin

Pentamidine and melarsoprol are primary drugs used to treat the lethal human slee** sickness caused by the parasite Trypanosoma brucei. Cross-resistance to these two drugs has recently been linked to aquaglycer...

Wanbiao Chen, Rongfeng Zou, Yi Mei, Jiawei Li, Yumi Xuan, Bing Cui… in Nature Communications (2024)

Article

High-throughput sequencing-based analysis of the composition and diversity of the endophyte community in roots of Stellera chamaejasme

Stellera chamaejasme (S. chamaejasme) is an important medicinal plant with heat-clearing, detoxifying, swelling and anti-inflammatory effects. At the same time, it is also one of the iconic plants of natural gras...

Jun-ze Zhang, **n-zhong Li, Ye-bing Yin, Si-cen Luo, Dong-xu Wang… in Scientific Reports (2024)

Article

Concerted transformation of a hyper-paused transcription complex and its reinforcing protein

RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical KOW domain sequesters the R...

Philipp K. Zuber, Nelly Said, Tarek Hilal, Bing Wang… in Nature Communications (2024)

Article

Artificial kagome lattices of Shockley surface states patterned by halogen hydrogen-bonded organic frameworks

Artificial electronic kagome lattices may emerge from electronic potential landscapes using customized structures with exotic supersymmetries, benefiting from the confinement of Shockley surface-state electron...

Ruoting Yin, **ang Zhu, Qiang Fu, Tianyi Hu, Lingyun Wan… in Nature Communications (2024)

Article

A prospective phase II clinical trial of total neoadjuvant therapy for locally advanced gastric cancer and gastroesophageal junction adenocarcinoma

To investigate the safety and efficacy of the neoadjuvant chemoradiotherapy (NCRT) followed by neoadjuvant consolidation chemotherapy (NCCT) and surgery for locally advanced gastric cancer (GC) or gastroesopha...

**-Ming Shi, Ning Li, Li-Ming Jiang, Lin Yang, Shu-Lian Wang… in Scientific Reports (2024)

Article

Tailoring d-band center of high-valent metal-oxo species for pollutant removal via complete polymerization

Polymerization-driven removal of pollutants in advanced oxidation processes (AOPs) offers a sustainable way for the simultaneous achievement of contamination abatement and resource recovery, supporting a low-c...

Hong-Zhi Liu, **ao-Xuan Shu, Mingjie Huang, Bing-Bing Wu… in Nature Communications (2024)

Article

Association of dietary live microbe intake with various cognitive domains in US adults aged 60 years or older

The purpose of this study was to explore whether dietary live microbe intake is associated with various cognitive domains using data from the National Health and Nutrition Examination Survey (NHANES) from 2011...

Jia-jie Lv, **n-yu Li, **g-bing Wang, **-tao Yang, Min-yi Yin… in Scientific Reports (2024)

Article

Addendum: Cellular differentiation into hyphae and spores in halophilic archaea

Shu-Kun Tang, **ao-Yang Zhi, Yao Zhang, Kira S. Makarova… in Nature Communications (2024)

Article

In vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy

Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4 (GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However, the wide application of GPX4...

Da-Yong Hou, Dong-Bing Cheng, Ni-Yuan Zhang, Zhi-Jia Wang… in Nature Communications (2024)

Article

Conserved and divergent gene regulatory programs of the mammalian neocortex

Divergence of cis-regulatory elements drives species-specific traits¹, but how this manifests in the evolution of the neocortex at the molecular and cellular level remains unclear. Here we investigated the gene r...

Nathan R. Zemke, Ethan J. Armand, Wenliang Wang, Seoyeon Lee, **gtian Zhou… in Nature (2023)

Article

Single-cell analysis of chromatin accessibility in the adult mouse brain

Recent advances in single-cell technologies have led to the discovery of thousands of brain cell types; however, our understanding of the gene regulatory programs in these cell types is far from complete^1–4. Here...

Songpeng Zu, Yang Eric Li, Kangli Wang, Ethan J. Armand, Sainath Mamde… in Nature (2023)

Article

Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain

Cytosine DNA methylation is essential in brain development and is implicated in various neurological disorders. Understanding DNA methylation diversity across the entire brain in a spatial context is fundament...

Hanqing Liu, Qiurui Zeng, **gtian Zhou, Anna Bartlett, Bang-An Wang… in Nature (2023)

Article

Application of bi-directional long-short-term memory network in cognitive age prediction based on EEG signals

Electroencephalography (EEG) measures changes in neuronal activity and can reveal significant changes from infancy to adulthood concomitant with brain maturation, making it a potential physiological marker of ...

Shi-Bing Wong, Yu Tsao, Wen-Hsin Tsai, Tzong-Shi Wang, Hsin-Chi Wu… in Scientific Reports (2023)

Article

Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion

Previous studies have speculated that brain activity directly controls immune responses in lymphoid organs. However, the upstream brain regions that control lymphoid organs and how they interface with lymphoid...

Dong-Dong Shi, Ying-Dan Zhang, Sen Zhang, Bing-Bing Liao… in Nature Communications (2023)

Article

Improvement of semantic segmentation through transfer learning of multi-class regions with convolutional neural networks on supine and prone breast MRI images

Semantic segmentation of breast and surrounding tissues in supine and prone breast magnetic resonance imaging (MRI) is required for various kinds of computer-assisted diagnoses for surgical applications. Varia...

Sungwon Ham, Minjee Kim, Sangwook Lee, Chuan-Bing Wang, BeomSeok Ko… in Scientific Reports (2023)

Article

Cellular differentiation into hyphae and spores in halophilic archaea

Several groups of bacteria have complex life cycles involving cellular differentiation and multicellular structures. For example, actinobacteria of the genus Streptomyces form multicellular vegetative hyphae, aer...

Shu-Kun Tang, **ao-Yang Zhi, Yao Zhang, Kira S. Makarova… in Nature Communications (2023)

Article

Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance

It is critical to understand factors associated with nasopharyngeal carcinoma (NPC) metastasis. To track the evolutionary route of metastasis, here we perform an integrative genomic analysis of 163 matched blo...

Mei Lin, **ao-Long Zhang, Rui You, You-** Liu, Hong-Min Cai… in Nature Communications (2023)

Article

20%-efficient polycrystalline Cd(Se,Te) thin-film solar cells with compositional gradient near the front junction

Bandgap gradient is a proven approach for improving the open-circuit voltages (V_OCs) in Cu(In,Ga)Se₂ and Cu(Zn,Sn)Se₂ thin-film solar cells, but has not been realized in Cd(Se,Te) thin-film solar cells, a leading...

Deng-Bing Li, Sandip S. Bista, Rasha A. Awni, Sabin Neupane… in Nature Communications (2022)

Article

Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration

Transplantation of mesenchymal stem cells (MSCs) holds promise to repair severe traumatic injuries. However, current transplantation practices limit the potential of this technique, either by losing the viable...

Yuanxiong Cao, Jiayi Tan, Haoran Zhao, Ting Deng, Yunxia Hu… in Nature Communications (2022)