29 Result(s)
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Article
Open AccessMulti-modal molecular determinants of clinically relevant osteoporosis subtypes
Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...
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Article
Open AccessSpatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression
Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar) histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but the molecular features ass...
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Open AccessTargeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia
Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly exp...
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Open AccessHigh-potency PD-1/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells
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Open AccessDNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0
Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand b...
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Open AccessCorticotropin releasing hormone promotes inflammatory bowel disease via inducing intestinal macrophage autophagy
Psychosocial stress is a vital factor contributing to the pathogenesis and progression of inflammatory bowel disease (IBD). The contribution of intestinal macrophage autophagy to the onset and development of I...
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Article
Open AccessSwiprosin-1 deficiency in macrophages alleviated atherogenesis
Macrophages play a vital role in the development of atherosclerosis. Previously, we have found that swiprosin-1 was abundantly expressed in macrophages. Here, we investigated the role of swiprosin-1 expressed ...
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Article
Open AccessSREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth
Renal cell carcinoma (RCC) cells have increased lipogenesis and cholesterol synthesis. Sterol regulatory element-binding protein-1 (SREBP1) is cleaved by site 1 protease (S1P) to release the transcriptionally ...
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Open AccessCartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury
Compelling evidence has revealed that biased activation of G protein-coupled receptor (GPCR) signaling, including angiotensin II (AngII) receptor type 1 (AT1) signaling, plays pivotal roles in vascular homeost...
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Article
Open AccessCirc_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation
With an increasing aging society, China is the world’s fastest growing markets for oral implants. Compared with traditional oral implants, immediate implants cause marginal bone resorption and increase the fai...
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Open AccessHomotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome
Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation. In an effort to unravel the basic principle underlyi...
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Open AccessTwo faces of bivalent domain regulate VEGFA responsiveness and angiogenesis
The bivalent domain (BD) at promoter region is an unique epigenetic feature poised for activation or repression during cell differentiation in embryonic stem cell. However, the function of BDs in already diffe...
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Open AccessHuman amniotic mesenchymal stem cells improve the follicular microenvironment to recover ovarian function in premature ovarian failure mice
Many adult women younger than 40 years old have premature ovarian failure (POF) and infertility. Previous studies confirmed that different tissue-derived stem cells could restore ovarian function and folliculo...
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Open AccessIntestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease
Psychosocial stress is a critical inducing factor of inflammatory bowel diseases (IBD), while autophagy is a novel central issue of IBD development. The present study investigated the potential role of autopha...
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Open AccessPhosphorylation of TET2 by AMPK is indispensable in myogenic differentiation
TET-mediated oxidation of 5-mC participates in both passive and active DNA demethylation, which exerts a significant influence on diverse biological processes. Mass spectrometry has identified multiple phospho...
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Open AccessNDRG2 suppression as a molecular hallmark of photoreceptor-specific cell death in the mouse retina
Photoreceptor cell death is recognized as the key pathogenesis of retinal degeneration, but the molecular basis underlying photoreceptor-specific cell loss in retinal damaging conditions is virtually unknown. ...
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Open AccessThe genomic landscape of small cell carcinoma of the esophagus
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Open AccessParkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1
Parkin (Park2), a RING-between-RING-type E3 ubiquitin ligase, has been implicated in regulating NF-κB. Mutations in Parkin are associated with Parkinson’s disease. Here we investigated the interaction of Parki...
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Correction to: Age at menarche and age at natural menopause in East Asian women: a genome-wide association study
The original version of this article unfortunately contained a mistake.
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Article
Open Access5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unkn...
