8 Result(s)
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Article
Open AccessMetagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease
The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins in patients with end-stage renal disease (ESRD). Our objective is to advance toward a holistic understanding of...
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Sprod for de-noising spatially resolved transcriptomics data based on position and image information
Spatially resolved transcriptomics (SRT) provide gene expression close to, or even superior to, single-cell resolution while retaining the physical locations of sequencing and often also providing matched path...
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Article
Integrated proteomic and metabolomic analysis of a reconstructed three-species microbial consortium for one-step fermentation of 2-keto-l-gulonic acid, the precursor of vitamin C
Microbial consortia, with the merits of strong stability, robustness, and multi-function, played critical roles in human health, bioenergy, and food manufacture, etc. On the basis of ‘build a consortium to und...
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An integrated catalog of reference genes in the human gut microbiome
Li et al. provide the largest catalog of genes in the human gut microbiome based on samples from >1,200 individuals across three continents.
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Identification of cross-linked peptides from complex samples
pLink, software for data analysis of cross-linked proteins coupled with mass spectrometry, estimates false discovery rate and enables analysis of protein complexes without extensive purification.
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Article
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
Methods for profiling DNA methylation differ in the physical principles used to detect modified cytosines. Harris et al. compare the performances of four sequencing-based technologies for genome-wide analysis of ...
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Article
Identification of a novel rice bZIP-type transcription factor gene,OsbZIP1, involved in response to infection ofMagnaporthe grisea
The basic leucine zipper (bZIP) proteins belong to a large family of transcriptional factors, some of which are thought to be involved in plant responses to biotic and abiotic stimuli. In this work, we cloned ...
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Article
Open AccessThe ASRG database: identification and survey of Arabidopsis thalianagenes involved in pre-mRNA splicing
A total of 74 small nuclear RNA (snRNA) genes and 395 genes encoding splicing-related proteins were identified in the Arabidopsis genome by sequence comparison and motif searches, including the previously elusive...
