-
Article
Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
-
Article
Experimental validation of inter-subspecific genetic diversity in rice represented by the differences between the DNA sequences of ‘Nipponbare’ and ‘93-11’
The pedigrees of three sequenced rice cultivars were analyzed to show that a majority of the genetic composition of ‘Nipponbare’ originates from japonica cultivars while the minority originates from indica cultiv...
-
Article
Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish
We previously reported a fusion protein NUP98–IQCG in an acute leukaemia, which functions as an aberrant regulator of transcriptional expression, yet the structure and function of IQCG have not been characteri...
-
Article
Open AccessMiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8
In this study we investigated the biological role and mechanism of miR-198 in colorectal carcinoma (CRC). MiR-198 expression was shown to exhibit a strongly negative correlation with lymph node invasion, dista...
-
Article
Revised Ti-in-biotite geothermometer for ilmenite- or rutile-bearing crustal metapelites
In the present study, the Ti-in-biotite geothermometer was revised using more than 300 natural rutile- or ilmenite-bearing metapelites collected worldwide. The formulation was empirically calibrated as ...
-
Article
Open AccessDesign and fabrication of far ultraviolet filters based on π-multilayer technology in high-k materials
Application of π-multilayer technology is extended to high extinction coefficient materials, which is introduced into metal-dielectric filter design. Metal materials often have high extinction coefficients in ...
-
Article
Open AccessMutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL
Patients with pancreatic ductal adenocarcinoma (PDAC) and preoperative CA19-9 ≥ 1,000 U/mL that does not decrease postresection have the worst prognosis, but the mechanism is unclear. Here, we elucidated the r...
-
Article
Open AccessThe distinct clinical features and prognosis of the CD10+MUM1+ and CD10−Bcl6−MUM1− diffuse large B-cell lymphoma
Using an immunohistochemistry (IHC) based method, diffuse large B-cell lymphoma (DLBCL) can be classified into germinal center B-cell (GCB) and non-GCB subtypes. However, the prognostic value of Hans algorithm...
-
Article
Open AccesscGMP Signalling Mediates Water Sensation (Hydrosensation) and Hydrotaxis in Caenorhabditis elegans
Animals have developed the ability to sense the water content in their habitats, including hygrosensation (sensing humidity in the air) and hydrosensation (sensing the water content in other microenvironments)...
-
Article
Open AccessTherapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat
Necroptosis has been shown as an alternative form of cell death in many diseases, but the detailed mechanisms of the neuron loss after traumatic brain injury (TBI) in rodents remain unclear. To investigate whe...
-
Article
Open AccessRetraction Note: Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL
Scientific Reports 6: Article number: 19222; published online: 12 January 2016; updated: 13 May 2016. The authors of this Article have requested that it is retracted. In the western blotting analysis, the rabb...
-
Article
Open AccessAccelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. How...
-
Article
Open AccessTranscription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
Browning of subcutaneous white fat (iWAT) involves several reprograming events, but the underlying mechanisms are incompletely understood. Here we show that the transcription factor Hlx is selectively expresse...
-
Article
Open AccessNetrin-1 promotes glioma growth by activating NF-κB via UNC5A
Gliomas, a common type of brain tumor, are characterized by aggressive infiltration, making it difficultly to cure by surgery. Netrin-1, an extracellular guidance cue critical for neuronal axon path-finding, h...
-
Article
Open AccessNon-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this stu...
-
Article
Open AccessIdentification of long non-coding RNAs in the immature and mature rat anterior pituitary
Many long non-coding RNAs (lncRNAs) have been identified in several types of human pituitary adenomas and normal anterior pituitary, some of which are involved in the pathogenesis of pituitary adenomas. Howeve...
-
Article
Open AccessSirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
Reversible post-translational modifications represent a mechanism to control tumor metabolism. Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and dema...
-
Article
Open AccessEffect of biodegradable chelators on induced phytoextraction of uranium- and cadmium- contaminated soil by Zebrina pendula Schnizl
This study investigated the effect of ethylenediamine-N,N′-disuccinic acid (EDDS), oxalic acid (OA), and citric acid (CA) on phytoextraction of U- and Cd-contaminated soil by Z. pendula. In this study, the biomas...
-
Article
Open AccessAuthor Correction: Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
-
Article
Open AccessGenomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...