65 Result(s)

Article

Correction: Anti-lymphangiogenesis for boosting drug accumulation in tumors

Chunling Wang, Junchao Xu, **aoyu Cheng, Ge Sun… in Signal Transduction and Targeted Therapy (2024)

Article

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years, but the limited efficiency of their infiltration into solid tumors makes it diff...

Rao Fu, Ruoyao Qi, Hualong **ong, **ng Lei… in Signal Transduction and Targeted Therapy (2024)

Article

Anti-lymphangiogenesis for boosting drug accumulation in tumors

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various str...

Chunling Wang, Junchao Xu, **aoyu Cheng, Ge Sun… in Signal Transduction and Targeted Therapy (2024)

Article

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronavi...

**ong **e, Qiaoshuai Lan, **yi Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure (HF). TEAD1 has been shown to be essential for heart development a...

Shuai Song, **aokai Zhang, Zihang Huang… in Signal Transduction and Targeted Therapy (2024)

Article

Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity

Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health security. In light of this ongoing threat, the development of a br...

Minghui Yang, Chunhui Li, Guoguo Ye… in Signal Transduction and Targeted Therapy (2024)

Article

SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis

Pinpin Sui, Guo Ge, Shi Chen, Jiaojiao Bai, Ivan P. Rubalcava, Hui Yang… in Leukemia (2024)

Article

Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis

Chongbiao Huang, Hui Li, Yang Xu, Chao Xu… in Signal Transduction and Targeted Therapy (2024)

Article

Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

Non-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are...

Tao Yuan, Chenming Zeng, Jiawei Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases. From the research history a...

Yongchao Zhao, Weidong **ong, Chaofu Li… in Signal Transduction and Targeted Therapy (2023)

Article

Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy

BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment. Although ...

Zhi-Qiang Wang, Zhao-Cong Zhang, Yu-Yang Wu… in Signal Transduction and Targeted Therapy (2023)

Article

Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma

The genomic instability (GI) /homologous recombination deficiency (HRD) score, calculated as the sum of the events of loss of heterozygosity (LOH), large-scale state transition (LST) and telomere allele imbala...

Juan Feng, Yang Lan, Feng Liu, Ye Yuan, Jia Ge, Sen Wei, Hu Luo… in npj Precision Oncology (2023)

Article

Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456

Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction (MI) heart failure (HF). Here, we report a novel small molecule HHQ16, an optimized derivative of astragaloside...

**g**g Wan, Zhen Zhang, Chennan Wu… in Signal Transduction and Targeted Therapy (2023)

Article

Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy

Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for develo** effective treatments. Here, we utilized single-cell transcriptomic analysis and inte...

Yi Wang, Laurence Don Wai Luu, Shuang Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis

Yi**g Lu, Wenlong Yang, Zhiyong Qi, Rifeng Gao… in Signal Transduction and Targeted Therapy (2023)

Article

Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions

Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms, and it has been proved that lymph nod...

Haoran Ji, Chuang Hu, Xuhui Yang, Yuanhao Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Nanoparticle-based multivalent human antibodies offer potent and broad neutralization against Omicron sublineages

Yizhen Wang, Feibo Song, Siling Wang… in Signal Transduction and Targeted Therapy (2023)

Article

BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis

VEGF inhibitors are one of the most successful antiangiogenic drugs in the treatment of many solid tumors. Nevertheless, pancreatic adenocarcinoma (PAAD) cells can reinstate tumor angiogenesis via activation o...

Chongbiao Huang, Hui Li, Yang Xu, Chao Xu… in Signal Transduction and Targeted Therapy (2023)

Article

Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling

The extracellular matrix (ECM) serves as signals that regulate specific cell states in tumor tissues. Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progressi...

Cong Li, Shi Qiu, **aohan Liu, Fengzhu Guo… in Signal Transduction and Targeted Therapy (2023)

Article

Neural stem cell-derived extracellular vesicles mitigate Alzheimer’s disease-like phenotypes in a preclinical mouse model

Ge Gao, Congcong Li, Yizhao Ma, Zhan** Liang… in Signal Transduction and Targeted Therapy (2023)