90 Result(s)

Article

Identification and functional analysis of multiple murine myeloperoxidase (MPO) promoters and comparison with the human MPO promoter region

Myeloperoxidase (MPO) is an important component of the oxidative antibacterial defense system of granulocytes. Mammalian MPO gene expression has been most extensively studied in human and murine cells. Transcr...

W-G Zhao, JP Lu, A Regmi, GE Austin in Leukemia (1997)

Article

Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone

Bone marrow from six patients with acute myeloid leukemia (AML) and t(8;21) (q22;q22) or a variant t(8;13;21) was studied by simultaneous analysis of cell morphology and karyotype. Combination of May–Grünwald–...

K van Lom, A Hagemeijer, F Vandekerckhove, GE de Greef, N Sacchi, B Löwenberg in Leukemia (1997)

Article

Development of an interphase fluorescent in situ hybridization (FISH) test to detect t(8;21) in AML patients

The translocation (8;21) is a chromosome abnormality associated with acute myeloid leukemia (AML). As a consequence of the translocation the AML1(CBFA2) gene in the 21q22 region is fused to the ETO(CDR,MTG8) gene...

A Hagemeijer, A de Klein, J Wijsman, E van Meerten, GE de Greef, N Sacchi in Leukemia (1998)

Article

The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia

Resistance to anthracyclines is related to a poor prognosis in childhood acute lymphoblastic leukemia (ALL). Resistance to this class of drugs may (partly) be reversed by modulating agents, as has been demonst...

ML Den Boer, R Pieters, KM Kazemier, GE Janka-Schaub, G Henze, AJP Veerman in Leukemia (1998)

Article

Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11) – a report of the Children’s Cancer Group

Infants less than 1 year of age at diagnosis of acute lymphoblastic leukemia (ALL) have a poor prognosis, which has been attributed primarily to a breakpoint in chromosomal band 11q23 or the MLL gene. Most infant...

NA Heerema, HN Sather, J Ge, DC Arthur, JM Hilden, ME Trigg, GH Reaman in Leukemia (1999)

Article

Relationship between the intracellular daunorubicin concentration, expression of major vault protein/lung resistance protein and resistance to anthracyclines in childhood acute lymphoblastic leukemia

In vitro resistance to anthracyclines is related to a poor prognosis in childhood acute lymphoblastic leukemia (ALL), but the underlying mechanisms are poorly understood. Using flow cytometry, we studied the cont...

ML Den Boer, R Pieters, KM Kazemier, GE Janka-Schaub, G Henze, AJP Veerman in Leukemia (1999)

Article

Long-term results of large prospective trials in childhood acute lymphoblastic leukemia

M Schrappe, B Camitta, C-H Pui in Leukemia (2000)

Article

Co-operative study group for childhood acute lymphoblastic leukemia (COALL): long-term follow-up of trials 82, 85, 89 and 92

The German Co-operative Study Group COALL for treatment of acute lymphoblastic leukemia (ALL) in childhood started the first trial in 1980. This report gives an overview of the long-term results of the four co...

DO Harms, GE Janka-Schaub in Leukemia (2000)

Article

Cloning and expression of human HBP1, a high mobility group protein that enhances myeloperoxidase (MPO) promoter activity

Factors which regulate transcription in immature myeloid cells are of great current interest for the light they may shed upon myeloid differentiation. In the course of screening for transcription factors which...

KM Lin, W-G Zhao, J Bhatnagar, W-D Zhao, J-P Lu, S Simko, A Schueneman… in Leukemia (2001)

Article

Functional activity of three distinct myeloperoxidase (MPO) promoters in human myeloid cells

The enzyme myeloperoxidase (MPO) is synthesized only in myeloid and monocytic cells, making it an important marker of the myeloid lineage. Transcription of the MPO gene is turned on early during the myeloblast...

KM Lin, GE Austin in Leukemia (2002)

Article

In vitro glucocorticoid resistance in childhood leukemia correlates with receptor affinity determined at 37°C, but not with affinity determined at room temperature

EG Haarman, GJL Kaspers, R Pieters, MMA Rottier, ML Den Boer, GE Janka-Schaub… in Leukemia (2002)

Article

High frequency of the 844ins68 cystathionine-β-synthase gene variant in Down syndrome children with acute myeloid leukemia

Y Ge, T Jensen, SJ James, DL Becton, GV Massey, HJ Weinstein, Y Ravindranath… in Leukemia (2002)

Article

The cyclosporin PSC 833 increases survival and delays engraftment of human multidrug-resistant leukemia cells in xenotransplanted NOD-SCID mice

Circumvention of chemoresistance in cancer may involve several modulator drugs with high affinity for the multidrug transporter P-glycoprotein (Pgp), which is expressed in a number of multi-resistant malignanc...

G Lehne, DR Sørensen, GE Tjønnfjord, C Beiske, T-A Hagve, HE Rugstad… in Leukemia (2002)

Article

Role of USF1 in the differential expression of the human deoxycytidine kinase gene in acute myeloid leukemia

Y Ge, T L Jensen, D A Tatman, M L Stout, S A Buck, Y Ravindranath, L H Matherly… in Leukemia (2005)

Article

The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells

Hemgn (a gene symbol for hemogen in mouse, EDAG in human and RP59 in rat) encodes a nuclear protein that is highly expressed in hematopoietic tissues and acute leukemia. To characterize its regulatory mechanisms,...

L V Yang, J Wan, Y Ge, Z Fu, S Y Kim, Y Fujiwara, J W Taub, L H Matherly… in Leukemia (2006)

Article

The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy

Acute myeloid leukemia (AML) in Down syndrome (DS) children has several unique features including a predominance of the acute megakaryocytic leukemia (AMkL) phenotype, higher event-free survivals compared to n...

Y Ge, K M LaFiura, A A Dombkowski, Q Chen, S G Payton, S A Buck, S Salagrama… in Leukemia (2008)

Article

Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy

Recent studies with very small numbers of patients showed that in some cases of childhood acute lymphoblastic leukemia (ALL), preleukemic cells are detectable on Guthrie cards that were used for newborn screen...

B Gruhn, J W Taub, Y Ge, J F Beck, R Zell, R Häfer, F H Hermann, K-M Debatin… in Leukemia (2008)

Article

The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group

We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on prognosis and downstream signaling in a well-defined cohort of 47 patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL). In ...

A Larson Gedman, Q Chen, S Kugel Desmoulin, Y Ge, K LaFiura, C L Haska… in Leukemia (2009)

Article

Acute myeloid leukemia cells harboring MLL fusion genes or with the acute promyelocytic leukemia phenotype are sensitive to the Bcl-2-selective inhibitor ABT-199

X Niu, G Wang, Y Wang, J T Caldwell, H Edwards, C **e, J W Taub, C Li, H Lin… in Leukemia (2014)