254 Result(s)

Article

Uptake, metabolism, and cytotoxicity of doxorubicin in human Ewing's sarcoma and rhabdomyosarcoma cells

Uptake, metabolism, and cytotoxicity of doxorubicin (DOX) in human Ewing's sarcoma (ES) and rhabdomyosarcoma (RS) cells were examined. Cellular uptake of DOX was determined by liquid scintillation spectrometry...

Michael W. DeGregorio, Ge Ming Lui, Bruce A. Macher… in Cancer Chemotherapy and Pharmacology (1984)

Article

Retardation of rat sciatic nerve regeneration after local application of minute doses of vincristine

The effect of vincristine on regeneration of rat sural and tibial nerves following a crush lesion of the sciatic nerve was studied in the pinch test. Vincristine locally applied through an osmotic minipump at ...

Gé S. F. Ruigt, Maria H. C. den Brok in Cancer Chemotherapy and Pharmacology (1995)

Article

Analysis of the cellular origin of hepatocellular carcinoma by p53 genotype

The polymerase chain reaction andHaeIII enzymatic digestion were used to study the seventh exon of the p53 gene in 29 primary and recurrent hepatomas in paraffin-embedded samples from 11 patients. The mutation ra...

Bin He, Zhao-You Tang, Kang-Da Liu, Ge Zhou in Journal of Cancer Research and Clinical On… (1996)

Article

Identification and functional analysis of multiple murine myeloperoxidase (MPO) promoters and comparison with the human MPO promoter region

Myeloperoxidase (MPO) is an important component of the oxidative antibacterial defense system of granulocytes. Mammalian MPO gene expression has been most extensively studied in human and murine cells. Transcr...

W-G Zhao, JP Lu, A Regmi, GE Austin in Leukemia (1997)

Article

Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone

Bone marrow from six patients with acute myeloid leukemia (AML) and t(8;21) (q22;q22) or a variant t(8;13;21) was studied by simultaneous analysis of cell morphology and karyotype. Combination of May–Grünwald–...

K van Lom, A Hagemeijer, F Vandekerckhove, GE de Greef, N Sacchi, B Löwenberg in Leukemia (1997)

Article

Reconstruction and expression of chimeric anti-HBx antibody inEscherichia coli

The variable regions of murine monoclonal anti-HBx immunoglobulin and the constant region of human antibody were cloned by reverse transcriptpolymerase chain reaction (RT-PCR). The heavy-chain and light-chain ...

Ge Zhou, Kang-Da Liu, Zhao-You Tang… in Journal of Cancer Research and Clinical On… (1997)

Article

Development of an interphase fluorescent in situ hybridization (FISH) test to detect t(8;21) in AML patients

The translocation (8;21) is a chromosome abnormality associated with acute myeloid leukemia (AML). As a consequence of the translocation the AML1(CBFA2) gene in the 21q22 region is fused to the ETO(CDR,MTG8) gene...

A Hagemeijer, A de Klein, J Wijsman, E van Meerten, GE de Greef, N Sacchi in Leukemia (1998)

Article

Case-control study of oral cancer in Shenyang, Northeastern China

To investigate the risk factors of oral cancer, a hospital-based case-control study was conducted from March 1989 to September 1995 in Shenyang, Liaoning Province, China.

Wei-Zhong Su, Yoshiyuki Ohno, Iwai Tohnai… in International Journal of Clinical Oncology (1998)

Article

The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia

Resistance to anthracyclines is related to a poor prognosis in childhood acute lymphoblastic leukemia (ALL). Resistance to this class of drugs may (partly) be reversed by modulating agents, as has been demonst...

ML Den Boer, R Pieters, KM Kazemier, GE Janka-Schaub, G Henze, AJP Veerman in Leukemia (1998)

Article

Invasion and metastasis of liver cancer: expression of intercellular adhesion molecule 1

To study the relationship between intercellular adhesion molecule 1 (ICAM-1) and liver cancer metastasis and to find predicting factors that could indicate the growth and metastasis of liver cancer. Methods: ICA...

**g-**g Sun, **n-Da Zhou, Yin-Kun Liu… in Journal of Cancer Research and Clinical On… (1999)

Article

Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11) – a report of the Children’s Cancer Group

Infants less than 1 year of age at diagnosis of acute lymphoblastic leukemia (ALL) have a poor prognosis, which has been attributed primarily to a breakpoint in chromosomal band 11q23 or the MLL gene. Most infant...

NA Heerema, HN Sather, J Ge, DC Arthur, JM Hilden, ME Trigg, GH Reaman in Leukemia (1999)

Article

Relationship between the intracellular daunorubicin concentration, expression of major vault protein/lung resistance protein and resistance to anthracyclines in childhood acute lymphoblastic leukemia

In vitro resistance to anthracyclines is related to a poor prognosis in childhood acute lymphoblastic leukemia (ALL), but the underlying mechanisms are poorly understood. Using flow cytometry, we studied the cont...

ML Den Boer, R Pieters, KM Kazemier, GE Janka-Schaub, G Henze, AJP Veerman in Leukemia (1999)

Article

Long-term results of large prospective trials in childhood acute lymphoblastic leukemia

M Schrappe, B Camitta, C-H Pui in Leukemia (2000)

Article

Co-operative study group for childhood acute lymphoblastic leukemia (COALL): long-term follow-up of trials 82, 85, 89 and 92

The German Co-operative Study Group COALL for treatment of acute lymphoblastic leukemia (ALL) in childhood started the first trial in 1980. This report gives an overview of the long-term results of the four co...

DO Harms, GE Janka-Schaub in Leukemia (2000)

Article

Cloning and expression of human HBP1, a high mobility group protein that enhances myeloperoxidase (MPO) promoter activity

Factors which regulate transcription in immature myeloid cells are of great current interest for the light they may shed upon myeloid differentiation. In the course of screening for transcription factors which...

KM Lin, W-G Zhao, J Bhatnagar, W-D Zhao, J-P Lu, S Simko, A Schueneman… in Leukemia (2001)

Article

Functional activity of three distinct myeloperoxidase (MPO) promoters in human myeloid cells

The enzyme myeloperoxidase (MPO) is synthesized only in myeloid and monocytic cells, making it an important marker of the myeloid lineage. Transcription of the MPO gene is turned on early during the myeloblast...

KM Lin, GE Austin in Leukemia (2002)

Article

In vitro glucocorticoid resistance in childhood leukemia correlates with receptor affinity determined at 37°C, but not with affinity determined at room temperature

EG Haarman, GJL Kaspers, R Pieters, MMA Rottier, ML Den Boer, GE Janka-Schaub… in Leukemia (2002)

Article

High frequency of the 844ins68 cystathionine-β-synthase gene variant in Down syndrome children with acute myeloid leukemia

Y Ge, T Jensen, SJ James, DL Becton, GV Massey, HJ Weinstein, Y Ravindranath… in Leukemia (2002)

Article

The cyclosporin PSC 833 increases survival and delays engraftment of human multidrug-resistant leukemia cells in xenotransplanted NOD-SCID mice

Circumvention of chemoresistance in cancer may involve several modulator drugs with high affinity for the multidrug transporter P-glycoprotein (Pgp), which is expressed in a number of multi-resistant malignanc...

G Lehne, DR Sørensen, GE Tjønnfjord, C Beiske, T-A Hagve, HE Rugstad… in Leukemia (2002)

Article

Octreotide acts as an antitumor angiogenesis compound and suppresses tumor growth in nude mice bearing human hepatocellular carcinoma xenografts

To investigate the effect of octreotide on angiogenesis induced by human hepatocellular carcinoma (HCC) and to evaluate whether octreotide can suppress tumor growth in nude mice bearing human HCC xenografts th...

Wei-Dong Jia, Ge-Liang Xu, Rong-Nan Xu… in Journal of Cancer Research and Clinical On… (2003)