122 Result(s)

Article

Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression

Cholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-like kinase 1 (DCLK1) promotes a variety of malignant cancers in their progression. Targ...

Ziwei Liang, Yang Ge, Jianjian Li… in Journal of Cancer Research and Clinical On… (2024)

Article

Anesthesia management for extended resection of thymic tumor combined with artificial bypass between the innominate vein and the right atrial appendage

YuanYuan Ma, JianYong Ding, Sheng** Ge in Clinical Cancer Bulletin (2024)

Article

Chemotherapy resistance in acute myeloid leukemia is associated with decreased anti-tumor immune response through MHC molecule and B7 family members

Acute myeloid leukemia (AML) remains challenging due to chemotherapeutic drug-resistance (CDR). Aberrant expression B7 family proteins are involved in tumors evasion. We wonder whether B7 family protein altera...

**g Ge, **aoxuan Yin, **n Sun, Liduo Kou, **n Xue, Juan Ma in Discover Oncology (2024)

Article

Correction: Anti-lymphangiogenesis for boosting drug accumulation in tumors

Chunling Wang, Junchao Xu, **aoyu Cheng, Ge Sun… in Signal Transduction and Targeted Therapy (2024)

Article

Combinational zimberelimab plus lenvatinib and chemotherapy for alpha-fetoprotein elevated, advanced gastric cancer patients (AFPGC): a phase 1 dose-escalation study

Alpha-fetoprotein elevated gastric cancer (AFPGC) got growing interests for its aggressive nature and unfavorable prognosis. Here, a phase 1 dose escalation study was conducted to evaluate safety and efficacy ...

Ting Deng, Feixue Wang, Le Zhang, Tao Ning, Yansha Sun… in Cancer Immunology, Immunotherapy (2024)

Article

A meta-analysis of MRI radiomics-based diagnosis for BI-RADS 4 breast lesions

The aim of this study is to conduct a systematic evaluation of the diagnostic efficacy of Breast Imaging Reporting and Data System (BI-RADS) 4 benign and malignant breast lesions using magnetic resonance imagi...

Jie Lin, Hao Zheng, Qiyu Jia, **g**g Shi… in Journal of Cancer Research and Clinical On… (2024)

Article

GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration

The variable responses to immunotherapy observed in gastric cancer (GC) patients can be attributed to the intricate nature of the tumor microenvironment. Glutathione (GSH) metabolism significantly influences the ...

Wen**g Zhao, Ziwei Liang, Yongshi Yao, Yang Ge… in Cancer Immunology, Immunotherapy (2024)

Article

Construction of a prognostic model for extensive-stage small cell lung cancer patients undergoing immune therapy in northernmost China and prediction of treatment efficacy based on response status at different time points

Recently, the emergence of immune checkpoint inhibitors has significantly improved the survival of patients with extensive-stage small cell lung cancer. However, not all patients can benefit from immunotherapy...

Junjie Dang, Gang Xu, Ge Guo, Huan Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years, but the limited efficiency of their infiltration into solid tumors makes it diff...

Rao Fu, Ruoyao Qi, Hualong **ong, **ng Lei… in Signal Transduction and Targeted Therapy (2024)

Article

Comprehensive analysis and prognostic assessment of senescence-associated genes in bladder cancer

The prevalence and mortality of bladder cancer (BLCA) present a significant medical challenge. While the function of senescence-related genes in tumor development is recognized, their prognostic significance i...

Ruilin Yang, Jieling He, Wenfeng Luo, Renyang **ang, Ge Zou… in Discover Oncology (2024)

Article

Case report: Mutation evolution in a patient with TdT positive high grade B cell lymphoma with MYC and BCL2 rearrangements following the treatment of concurrent follicular lymphoma and diffuse large B-cell lymphoma

Concurrent follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)was reported in some studies, while the diagnosis of TdT (terminal deoxynucleotydil transferase) positive high grade B cell lymphoma...

Fen Zhang, Yu Chen, Qian Cui, Yan Ge, Yanhui Liu in Discover Oncology (2024)

Article

Anti-lymphangiogenesis for boosting drug accumulation in tumors

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various str...

Chunling Wang, Junchao Xu, **aoyu Cheng, Ge Sun… in Signal Transduction and Targeted Therapy (2024)

Article

Novel insights into TCR-T cell therapy in solid neoplasms: optimizing adoptive immunotherapy

Adoptive immunotherapy in the T cell landscape exhibits efficacy in cancer treatment. Over the past few decades, genetically modified T cells, particularly chimeric antigen receptor T cells, have enabled remar...

Weihuan Shao, Yiran Yao, Ludi Yang, **aoran Li… in Experimental Hematology & Oncology (2024)

Article

Ezabenlimab (BI 754091), an anti-PD-1 antibody, in patients with advanced solid tumours

Ezabenlimab (BI 754091) is a humanised monoclonal antibody targeting programmed cell death protein-1. We report results from open-label, dose-escalation/expansion, Phase I trials that evaluated the safety, max...

Manish R. Patel, Melissa Johnson, Ira Winer… in Cancer Immunology, Immunotherapy (2024)

Article

PD-(L)1 inhibitors plus bevacizumab and chemotherapy as first-line therapy in PD-L1-negative metastatic lung adenocarcinoma: a real-world data

Chemotherapy combined with immune checkpoint inhibitors (IC), bevacizumab (BC), or both (IBC) is the preferred first-line therapy for PD-L1-negative and oncogenic-driver wild-type metastatic lung adenocarcinom...

Yihui Ge, Yu**g Zhan, Jie He, Juan Li… in Journal of Cancer Research and Clinical On… (2024)

Article

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronavi...

**ong **e, Qiaoshuai Lan, **yi Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Integrating molecular subtype and CD8⁺ T cells infiltration to predict treatment response and survival in muscle-invasive bladder cancer

Luminal and Basal are the primary intrinsic subtypes of muscle-invasive bladder cancer (MIBC). The presence of CD8⁺ T cells infiltration holds significant immunological relevance, potentially influencing the effi...

Bingyu Li, Kaifeng **, Zhaopei Liu, **aohe Su… in Cancer Immunology, Immunotherapy (2024)

Article

Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6

Helicobacter pylori (H. pylori, Hp) has been designated a class I carcinogen and is closely associated with severe gastric diseases. During colonization in the gastric mucosa, H. pylori develops immune escape by ...

**ulin Zhang, Yang He, **aolu Zhang, Bo Fu, Zidai Song, Liang Wang… in Gastric Cancer (2024)

Article

TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure (HF). TEAD1 has been shown to be essential for heart development a...

Shuai Song, **aokai Zhang, Zihang Huang… in Signal Transduction and Targeted Therapy (2024)

Article

Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity

Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health security. In light of this ongoing threat, the development of a br...

Minghui Yang, Chunhui Li, Guoguo Ye… in Signal Transduction and Targeted Therapy (2024)