156 Result(s)

Article

Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression

Cholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-like kinase 1 (DCLK1) promotes a variety of malignant cancers in their progression. Targ...

Ziwei Liang, Yang Ge, Jianjian Li… in Journal of Cancer Research and Clinical On… (2024)

Article

Chemotherapy resistance in acute myeloid leukemia is associated with decreased anti-tumor immune response through MHC molecule and B7 family members

Acute myeloid leukemia (AML) remains challenging due to chemotherapeutic drug-resistance (CDR). Aberrant expression B7 family proteins are involved in tumors evasion. We wonder whether B7 family protein altera...

**g Ge, **aoxuan Yin, **n Sun, Liduo Kou, **n Xue, Juan Ma in Discover Oncology (2024)

Article

Correction: Anti-lymphangiogenesis for boosting drug accumulation in tumors

Chunling Wang, Junchao Xu, **aoyu Cheng, Ge Sun… in Signal Transduction and Targeted Therapy (2024)

Article

A meta-analysis of MRI radiomics-based diagnosis for BI-RADS 4 breast lesions

The aim of this study is to conduct a systematic evaluation of the diagnostic efficacy of Breast Imaging Reporting and Data System (BI-RADS) 4 benign and malignant breast lesions using magnetic resonance imagi...

Jie Lin, Hao Zheng, Qiyu Jia, **g**g Shi… in Journal of Cancer Research and Clinical On… (2024)

Article

Construction of a prognostic model for extensive-stage small cell lung cancer patients undergoing immune therapy in northernmost China and prediction of treatment efficacy based on response status at different time points

Recently, the emergence of immune checkpoint inhibitors has significantly improved the survival of patients with extensive-stage small cell lung cancer. However, not all patients can benefit from immunotherapy...

Junjie Dang, Gang Xu, Ge Guo, Huan Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years, but the limited efficiency of their infiltration into solid tumors makes it diff...

Rao Fu, Ruoyao Qi, Hualong **ong, **ng Lei… in Signal Transduction and Targeted Therapy (2024)

Article

Comprehensive analysis and prognostic assessment of senescence-associated genes in bladder cancer

The prevalence and mortality of bladder cancer (BLCA) present a significant medical challenge. While the function of senescence-related genes in tumor development is recognized, their prognostic significance i...

Ruilin Yang, Jieling He, Wenfeng Luo, Renyang **ang, Ge Zou… in Discover Oncology (2024)

Article

Case report: Mutation evolution in a patient with TdT positive high grade B cell lymphoma with MYC and BCL2 rearrangements following the treatment of concurrent follicular lymphoma and diffuse large B-cell lymphoma

Concurrent follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)was reported in some studies, while the diagnosis of TdT (terminal deoxynucleotydil transferase) positive high grade B cell lymphoma...

Fen Zhang, Yu Chen, Qian Cui, Yan Ge, Yanhui Liu in Discover Oncology (2024)

Article

Anti-lymphangiogenesis for boosting drug accumulation in tumors

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various str...

Chunling Wang, Junchao Xu, **aoyu Cheng, Ge Sun… in Signal Transduction and Targeted Therapy (2024)

Article

PD-(L)1 inhibitors plus bevacizumab and chemotherapy as first-line therapy in PD-L1-negative metastatic lung adenocarcinoma: a real-world data

Chemotherapy combined with immune checkpoint inhibitors (IC), bevacizumab (BC), or both (IBC) is the preferred first-line therapy for PD-L1-negative and oncogenic-driver wild-type metastatic lung adenocarcinom...

Yihui Ge, Yu**g Zhan, Jie He, Juan Li… in Journal of Cancer Research and Clinical On… (2024)

Article

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronavi...

**ong **e, Qiaoshuai Lan, **yi Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure (HF). TEAD1 has been shown to be essential for heart development a...

Shuai Song, **aokai Zhang, Zihang Huang… in Signal Transduction and Targeted Therapy (2024)

Article

Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity

Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health security. In light of this ongoing threat, the development of a br...

Minghui Yang, Chunhui Li, Guoguo Ye… in Signal Transduction and Targeted Therapy (2024)

Article

MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial–mesenchymal transition in lung adenocarcinoma

To explore the effect of microtubule-associated protein 4 (MAP4) on lung adenocarcinoma cells in vitro and evaluate its prognostic value. Radioresistance, indicated by reduced efficiency of radiotherapy, is a...

**aochun **a, Yangyang Ge, Fanghong Ge… in Journal of Cancer Research and Clinical On… (2024)

Article

SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis

Pinpin Sui, Guo Ge, Shi Chen, Jiaojiao Bai, Ivan P. Rubalcava, Hui Yang… in Leukemia (2024)

Article

Multi-omics and Multi-VOIs to predict esophageal fistula in esophageal cancer patients treated with radiotherapy

This study aimed to develop a prediction model for esophageal fistula (EF) in esophageal cancer (EC) patients treated with intensity-modulated radiation therapy (IMRT), by integrating multi-omics features from...

Wei Guo, Bing Li, Wencai Xu, Chen Cheng… in Journal of Cancer Research and Clinical On… (2024)

Article

Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis

Chongbiao Huang, Hui Li, Yang Xu, Chao Xu… in Signal Transduction and Targeted Therapy (2024)

Article

Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

Non-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are...

Tao Yuan, Chenming Zeng, Jiawei Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Potential value of mitochondrial regulatory pathways in the clinical application of clear cell renal cell carcinoma: a machine learning-based study

Renal clear cell carcinoma (RCC) is a common cancer in urinary system with increasing incidence. At present, targeted therapy and immunotherapy are the main therapeutic programs in clinical therapy. To develop...

**aochen Qi, Yangyang Ge, Ao Yang… in Journal of Cancer Research and Clinical On… (2023)