543 Result(s)

Article

Synthetic macrolides overcoming MLS_BK-resistant pathogens

Conventional macrolide-lincosamide-streptogramin B-ketolide (MLS_BK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...

Cong-Xuan Ma, Ye Li, Wen-Tian Liu, Yun Li, Fei Zhao, **ao-Tian Lian… in Cell Discovery (2024)

Article

Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer

Colorectal cancer (CRC) is one of the most common tumors of the digestive system worldwide. KRAS mutations limit the use of anti-EGFR antibodies in combination with chemotherapy for the treatment of CRC. There...

Ya-nan Zheng, Si-yue Lou, Jun Lu, Fan-li Zheng, Yong-mei Tang… in Cell Death & Disease (2024)

Article

PEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3

The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...

Jia-Teng Sun, Zi-Mu Wang, Liu-Hua Zhou, Tong-Tong Yang, Di Zhao… in Communications Biology (2024)

Article

Metabolic differences in MSTN and FGF5 dual-gene edited sheep muscle cells during myogenesis

Dynamic metabolic reprogramming occurs at different stages of myogenesis and contributes to the fate determination of skeletal muscle satellite cells (MuSCs). Accumulating evidence suggests that mutations in m...

Mingming Chen, Yan Li, Xueling Xu, Shuqi Wang, Zhimei Liu, Shiyu Qi… in BMC Genomics (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

Different metazoan parasites, different transcriptomic responses, with new insights on parasitic castration by digenetic trematodes in the schistosome vector snail Biomphalaria glabrata

Gastropods of the genus Biomphalaria (Family Planorbidae) are exploited as vectors by Schistosoma mansoni, the most common causative agent of human intestinal schistosomiasis. Using improved genomic resources, ov...

Lijun Lu, Li**g Bu, Martina R. Laidemitt, Si-Ming Zhang, Eric S. Loker in BMC Genomics (2024)

Article

Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression

Glioma is a common tumor that occurs in the brain and spinal cord. Hypoxia is a crucial feature of the tumor microenvironment. Tumor-associated macrophages/microglia play a crucial role in the advancement of g...

**chao Si, **gya Guo, Xu Zhang, Wei Li, Shen Zhang, Shuyu Shang… in Biology Direct (2024)

Article

Publisher Correction: SGF29 nuclear condensates reinforce cellular aging

Kaowen Yan, Qianzhao Ji, Dongxin Zhao, Mingheng Li, **aoyan Sun… in Cell Discovery (2024)

Article

Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease

Ubiquitin-proteasome system dysfunction triggers α-synuclein aggregation, a hallmark of neurodegenerative diseases, such as Parkinson’s disease (PD). However, the crosstalk between deubiquitinating enzyme (DUB...

Liuyan Ding, Lin Lu, Shaohui Zheng, Zhiling Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Growth phase-dependent reorganization of cryptophyte photosystem I antennae

Photosynthetic cryptophytes are eukaryotic algae that utilize membrane-embedded chlorophyll a/c binding proteins (CACs) and lumen-localized phycobiliproteins (PBPs) as their light-harvesting antennae. Cryptoph...

Shumeng Zhang, Long Si, **aodong Su, Xuelin Zhao, **aomin An… in Communications Biology (2024)

Article

Development and verification of a 10K liquid chip for Hainan black goat based on genoty** by pinpoint sequencing of liquid captured targets

China has thousands years of goat breeding and abundant goat genetic resources. Additionally, the Hainan black goat is one of the high-quality local goat breeds in China. In order to conserve the germplasm res...

Yong Meng, Wencan Zhang, Yiwen Cheng, Yanru Wu, Haotian Wu, Meirong He… in BMC Genomic Data (2024)

Article

Hepatic Sirt6 activation abrogates acute liver failure

Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-ind...

**que Luo, Huan Liu, Yanni Xu, Nanhui Yu, Rebbeca A. Steiner… in Cell Death & Disease (2024)

Article

Differences in diacylglycerol acyltransferases expression patterns and regulation cause distinct hepatic triglyceride deposition in fish

Triglyceride (TAG) deposition in the liver is associated with metabolic disorders. In lower vertebrate, the propensity to accumulate hepatic TAG varies widely among fish species. Diacylglycerol acyltransferase...

**aojun **ang, Renlei Ji, Shangzhe Han, **ang Xu, Si Zhu… in Communications Biology (2024)