371 Result(s)

Article

Synthetic macrolides overcoming MLS_BK-resistant pathogens

Conventional macrolide-lincosamide-streptogramin B-ketolide (MLS_BK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...

Cong-Xuan Ma, Ye Li, Wen-Tian Liu, Yun Li, Fei Zhao, **ao-Tian Lian… in Cell Discovery (2024)

Article

Investigation of the Circular Transcriptome in Alzheimer’s Disease Brain

Circular RNAs (circRNAs) are a subclass of non-coding RNAs which have demonstrated potential as biomarkers for Alzheimer’s disease (AD). In this study, we conducted a comprehensive exploration of the circRNA t...

Yulan Gao, Si-Mei Xu, Yuning Cheng, Konii Takenaka… in Journal of Molecular Neuroscience (2024)

Article

Effect of Post-transplant Dietary Restriction on Hematopoietic Reconstitution and Maintenance of Reconstitution Capacity of Hematopoietic Stem Cells

Hematopoietic cell transplantation (HCT) is an important therapy for many hematological malignancies as well as some non-malignant diseases. Post-transplant hematopoiesis is affected by multiple factors, and t...

Si Tao, **ngxing Qiu, Yiting Wang, Rongrong Qiu… in Stem Cell Reviews and Reports (2024)

Article

The role of lncRNA NEAT1 in human cancer chemoresistance

Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become ...

Feng Long, Xue Li, **gyu Pan, Hailin Ye, Cuixia Di… in Cancer Cell International (2024)

Article

Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer

Colorectal cancer (CRC) is one of the most common tumors of the digestive system worldwide. KRAS mutations limit the use of anti-EGFR antibodies in combination with chemotherapy for the treatment of CRC. There...

Ya-nan Zheng, Si-yue Lou, Jun Lu, Fan-li Zheng, Yong-mei Tang… in Cell Death & Disease (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels

Myocardial infarction (MI) results in prolonged ischemia and the subsequent cell death leads to heart failure which is linked to increased deaths or hospitalizations. New therapeutic targets are urgently neede...

Hengshu Chen, Si Wang, **aoling Zhang, **ng Hua… in Functional & Integrative Genomics (2024)

Article

A Bibliometric Analysis of the Spatial Transcriptomics Literature from 2006 to 2023

In recent years, spatial transcriptomics (ST) research has become a popular field of study and has shown great potential in medicine. However, there are few bibliometric analyses in this field. Thus, in this s...

Shu-Han Zhao, **n-Yu Ji, Guo-Zhen Yuan, Tao Cheng… in Cellular and Molecular Neurobiology (2024)

Article

Publisher Correction: SGF29 nuclear condensates reinforce cellular aging

Kaowen Yan, Qianzhao Ji, Dongxin Zhao, Mingheng Li, **aoyan Sun… in Cell Discovery (2024)

Article

Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease

Ubiquitin-proteasome system dysfunction triggers α-synuclein aggregation, a hallmark of neurodegenerative diseases, such as Parkinson’s disease (PD). However, the crosstalk between deubiquitinating enzyme (DUB...

Liuyan Ding, Lin Lu, Shaohui Zheng, Zhiling Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Spatial transcriptomics reveals gene interactions and signaling pathway dynamics in rat embryos with anorectal malformation

Anorectal malformation (ARM) is a prevalent early pregnancy digestive tract anomaly. The intricate anatomy of the embryonic cloaca region makes it challenging for traditional high-throughput sequencing methods...

Chen-Yi Wang, Mu-Yu Li, Si-Ying Li, **ao-Gao Wei… in Cell Biology and Toxicology (2024)

Article

Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3

Helicobacter pylori (H. pylori) is the predominant etiological agent of gastritis and disrupts the integrity of the gastric mucosal barrier through various pathogenic mechanisms. After H. pylori invades the gastr...

Yan-Fei Wei, Xue Li, Meng-Ran Zhao, Si Liu, Li Min… in Cell Communication and Signaling (2024)

Article

Electroacupuncture Exerts Analgesic Effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory Pain

As one of the commonly used therapies for pain-related diseases in clinical practice, electroacupuncture (EA) has been proven to be effective. In chronic pain, neurons in the anterior cingulate cortex (ACC) ha...

Junshang Wu, Libo Hua, Wenhao Liu, **aoyun Yang, … in Molecular Neurobiology (2024)

Article

Hepatic Sirt6 activation abrogates acute liver failure

Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-ind...

**que Luo, Huan Liu, Yanni Xu, Nanhui Yu, Rebbeca A. Steiner… in Cell Death & Disease (2024)

Article

METTL14 downregulation drives S100A4⁺ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

Without intervention, a considerable proportion of patients with metabolism‐associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism‐associated steatohepatitis (MASH), liver fib...

Yue-fan Wang, Wen-li Zhang, Zhi-xuan Li… in Signal Transduction and Targeted Therapy (2024)

Article

FoxG1 as a Potential Therapeutic Target for Alzheimer’s Disease: Modulating NLRP3 Inflammasome via AMPK/mTOR Autophagy Pathway

An increasing body of research suggests that promoting microglial autophagy hinders the neuroinflammation initiated though the NLRP3 inflammasome activation in Alzheimer’s disease (AD). The function of FoxG1, ...

Qi Yun, Si-Fei Ma, Wei-Ning Zhang, Meng Gu, Jia Wang in Cellular and Molecular Neurobiology (2024)

Article

Enhancing therapeutic efficacy in luminal androgen receptor triple-negative breast cancer: exploring chidamide and enzalutamide as a promising combination strategy

Extensive exploration of the molecular subtypes of triple-negative breast cancer (TNBC) is critical for advancing precision medicine. Notably, the luminal androgen receptor (LAR) subtype has attracted attentio...

Ya-**n Zhao, Han Wang, Si-Wei Zhang, Wei-**n Zhang… in Cancer Cell International (2024)

Article

Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson’s disease

The pathogenesis of Parkinson’s disease (PD) is strongly associated with neuroinflammation, and type I interferons (IFN-I) play a crucial role in regulating immune and inflammatory responses. However, the spec...

Pusheng Quan, Xueying Li, Yao Si, Linlin Sun… in Cell Communication and Signaling (2024)

Article

Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in col...

Ri-**n Chen, Shui-Dan Xu, Min-Hua Deng… in Signal Transduction and Targeted Therapy (2024)

Article

RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and ins...

Wei-Wei Liu, Si-Qing Zheng, Tian Li… in Signal Transduction and Targeted Therapy (2024)