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  1. Article

    Open Access

    miR-324-3p Suppresses Hepatic Stellate Cell Activation and Hepatic Fibrosis Via Regulating SMAD4 Signaling Pathway

    In hepatic fibrosis (HF), hepatic stellate cells (HSCs) form the extracellular matrix (ECM), and the pathological accumulation of ECM in the liver leads to inflammation. Our previous research found that miR-32...

    Si-Yu Chen, **n Chen, Sai Zhu, **-** Xu, **ao-Feng Li… in Molecular Biotechnology (2024)

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  2. No Access

    Article

    Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma

    Drug addiction, a phenomenon where cancer cells paradoxically depend on continuous drug treatment for survival, has uncovered cell signaling mechanisms and cancer codependencies. Here we discover mutations tha...

    Hui Si Kwok, Allyson M. Freedy, Allison P. Siegenfeld… in Nature Chemical Biology (2023)

  3. No Access

    Article

    LncRNA LINC02535 Induces Colorectal Adenocarcinoma Progression via Modulating miR-30d-5p/CHD1

    Growing evidence has suggested that lncRNAs play a significant role in the development of colorectal adenocarcinoma. LncRNA LINC02535 was a potential novel lncRNA marker of neoplastic processes of the colon. N...

    Jiguang Li, Jianhua Xu, Sen Zheng, Si Cheng in Molecular Biotechnology (2023)

  4. No Access

    Article

    The Circular RNA circSKA3 Facilitates the Malignant Biological Behaviors of Medulloblastoma via miR-520 h/CDK6 Pathway

    Circular RNAs (circRNAs) are reported to participate in the development of diverse human malignancies. This work investigated the mechanism of circSKA3 in modulating medulloblastoma progression. A total of 15 ...

    Xu-chang Liu, Fa-Chen Wang, Ji-Hong Wang, Jun-Yan Zhao… in Molecular Biotechnology (2022)

  5. No Access

    Article

    The Clinical Significance and Functional Role of miR-466 in Gastric Cancer Peritoneal Metastasis

    The prognosis of metastasis gastric cancer patients remains poor and the identification of novel molecular markers will improve the management of gastric cancer patients. The present study aimed to investigate...

    Yong Wang, Bo Yan, Lei Ni, Yunfei Si, **li Cao in Molecular Biotechnology (2022)

  6. No Access

    Article

    Purification and Characterization of (2R,3R)-2,3-Butanediol Dehydrogenase of the Human Pathogen Neisseria gonorrhoeae FA1090 Produced in Escherichia coli

    2,3-Butanediol dehydrogenase (BDH), also known as acetoin/diacetyl reductase, is a pivotal enzyme for the formation of 2,3-butanediol (2,3-BD), a chiral compound with potential roles in the virulence of certai...

    Wanggang Tang, Chaoqun Lian, Yu Si, Jianrong Chang in Molecular Biotechnology (2021)

  7. No Access

    Article

    Functional elucidation of TfuA in peptide backbone thioamidation

    YcaO enzymes catalyze several post-translational modifications on peptide substrates, including thioamidation, which substitutes an amide oxygen with sulfur. Most predicted thioamide-forming YcaO enzymes are e...

    Andi Liu, Yuanyuan Si, Shi-Hui Dong, Nilkamal Mahanta… in Nature Chemical Biology (2021)

  8. No Access

    Article

    Development of a chemical probe against NUDT15

    The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical respon...

    Si Min Zhang, Matthieu Desroses, Anna Hagenkort… in Nature Chemical Biology (2020)

  9. No Access

    Article

    Molecular Characterization, Localization, and Distribution of Innexins in the Silkworm, Bombyx mori

    Gap junctions that allow for a direct exchange of second messenger and ions are the most conserved cellular structures in multicellular organisms. We have isolated and characterized a Bombyx mori gene innexin3 th...

    Sun Mee Hong, Si Kab Noh, Kyung A. Kim, Hitoshi Mitsunobu… in Molecular Biotechnology (2009)

  10. No Access

    Article

    production of transgenic rodents by the microinjection of cloned DNA into fertilized one-cell eggs

    Transgenic technologies that enable rapid movement between genotype and phenotype through specific loss-of-function, overexpression, or misexpression phenotypes will be crucial in the elucidation of gene seque...

    San Ling Si-Hoe, Sara Wells, Professor David Murphy in Molecular Biotechnology (2001)