751 Result(s)

Article

Tracking the hologenome dynamics in aquatic invertebrates by the holo-2bRAD approach

The “hologenome” concept is an increasingly popular way of thinking about microbiome-host for marine organisms. However, it is challenging to track hologenome dynamics because of the large amount of material, ...

Cen Ma, Chang Xu, Tianqi Zhang, Qianqian Mu, Jia Lv, Qiang **ng… in Communications Biology (2024)

Article

A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug

SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding domain. Blocking this interaction has been proven to be an ...

Qianyun Liu, Yuchi Lu, Chenguang Cai, Yanyan Huang, Li Zhou… in Cell Death & Disease (2024)

Article

LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism

LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed ...

Zhan Liu, Kexin Fan, Aikedaimu Abudukeremu, Min Gao, **nyue Tan… in Cell Death Discovery (2024)

Article

Deciphering spatial domains from spatial multi-omics with SpatialGlue

Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integr...

Yahui Long, Kok Siong Ang, Raman Sethi, Sha Liao, Yang Heng… in Nature Methods (2024)

Article

Genome-wide identification of ATG genes and their expression profiles under biotic and abiotic stresses in Fenneropenaeus chinensis

Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival in response to multiple stresses and is important for organism fitness. Extensive research has shown that autophagy pl...

Chenhui Guan, Yalun Li, Qiong Wang, Jiajia Wang, Caijuan Tian, Yuying He… in BMC Genomics (2024)

Article

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining...

Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan… in Cell Death & Disease (2024)

Article

Environment influences the genetic structure and genetic differentiation of Sassafras tzumu (Lauraceae)

Sassafras tzumu, an elegant deciduous arboreal species, belongs to the esteemed genus Sassafras within the distinguished family Lauraceae. With its immense commercial value, escalating market demands and unforese...

Bicai Guan, Qian Liu, **ang Liu, ** Gong in BMC Ecology and Evolution (2024)

Article

Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction

Subclonal reconstruction algorithms use bulk DNA sequencing data to quantify parameters of tumor evolution, allowing an assessment of how cancers initiate, progress and respond to selective pressures. We launc...

Adriana Salcedo, Maxime Tarabichi, Alex Buchanan… in Nature Biotechnology (2024)

Article

Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru… in Nature Biotechnology (2024)

Article

Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan… in Nature Biotechnology (2024)

Article

Aging atlas reveals cell-type-specific effects of pro-longevity strategies

Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan across species. However, how age-related molecular changes di...

Shihong Max Gao, Yanyan Qi, Qinghao Zhang, Youchen Guan, Yi-Tang Lee… in Nature Aging (2024)

Article

HAX-1 interferes in assembly of NLRP3-ASC to block microglial pyroptosis in cerebral I/R injury

Acute cerebral ischemia has a high rate of disability and death. Although timely recanalization therapy may rescue the ischemic brain tissue, cerebral ischemia-reperfusion injury has been shown to limit the th...

**n-bin Guo, **n Deng, **g**g Wang, Yuruo Qi, Wen Zhao… in Cell Death Discovery (2024)

Article

Single-cell transcriptomic landscape and the microenvironment of normal adjacent tissues in hypopharyngeal carcinoma

The cellular origin of hypopharyngeal diseases is crucial for further diagnosis and treatment, and the microenvironment in tissues may also be associated with specific cell types at the same time. Normal adjac...

Rui Guan, Ce Li, Fangmeng Gu, Wenming Li, Dongmin Wei, Shengda Cao… in BMC Genomics (2024)

Article

Identification and affinity enhancement of T-cell receptor targeting a KRAS^G12V cancer neoantigen

Neoantigens derived from somatic mutations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), the most frequently mutated oncogene, represent promising targets for cancer immunotherapy. Recent research high...

Mengyu Zhang, Wei Xu, Lingjie Luo, Fenghui Guan, **angyao Wang… in Communications Biology (2024)