305 Result(s)
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Life Sciences
Biochemistry, general
Cell Biology
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Article
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Article
Rutin Ameliorates Toxoplasma gondii-Induced Brain Tissue Damage via Inhibiting P2X7R/NLRP3 Pro-Inflammatory and Enhancing PI3K/AKT/Nrf2/HO-1 Antioxidant Signaling Pathway
Bain damage caused by Toxoplasma gondii (T. gondii) is associated with increased inflammatory response and oxidative stress. Rutin, a natural product extracted from tobacco leaves and tomatoes, has excellent anti...
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Open AccessDelivery of miR-15b-5p via magnetic nanoparticle-enhanced bone marrow mesenchymal stem cell-derived extracellular vesicles mitigates diabetic osteoporosis by targeting GFAP
Diabetic osteoporosis (DO) presents significant clinical challenges. This study aimed to investigate the potential of magnetic nanoparticle-enhanced extracellular vesicles (GMNPE-EVs) derived from bone marrow mes...
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Open AccessA broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug
SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding domain. Blocking this interaction has been proven to be an ...
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Open AccessLIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism
LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed ...
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Open AccessHippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity
Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining...
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Open AccessHAX-1 interferes in assembly of NLRP3-ASC to block microglial pyroptosis in cerebral I/R injury
Acute cerebral ischemia has a high rate of disability and death. Although timely recanalization therapy may rescue the ischemic brain tissue, cerebral ischemia-reperfusion injury has been shown to limit the th...
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Open AccessEmerging microalgal feed additives for ruminant production and sustainability
The global demand for animal-derived foods has led to a substantial expansion in ruminant production, which has raised concerns regarding methane emissions. To address these challenges, microalgal species that...
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Open AccessNLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...
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Open AccessTMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression
Abnormal Transmembrane protein 9 (TMEM9) expression has been identified in various human tumors. However, the prognostic potential and mechanistic role of TMEM9 in lung adenocarcinoma (LUAD) remain unclear. Here,...
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Open AccessWhen DNA-damage responses meet innate and adaptive immunity
When cells proliferate, stress on DNA replication or exposure to endogenous or external insults frequently results in DNA damage. DNA-Damage Response (DDR) networks are complex signaling pathways used by multi...
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Open AccessCold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult
Cold-inducible RNA binding protein (CIRBP), a stress response protein, protects cells from mild hypothermia or hypoxia by stabilizing specific mRNAs and promoting their translation. Neurons subjected to hypoba...
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Open AccessSialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
Small extracellular vesicles (sEV) are closely associated with the development and metastasis of many types of mammalian cancer. Glycoconjugates are highly expressed on sEV and play important roles in sEV biog...
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Open AccessTRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2
Abnormal lipid metabolism and lipid accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely linking such lipid accumulation within RCC cells and consequen...
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Comprehensive genomic analysis of Burkholderia arboris PN-1 reveals its biocontrol potential against Fusarium solani-induced root rot in Panax notoginseng
Panax notoginseng (Burkill) F.H. Chen, a valuable traditional Chinese medicine, faces significant yield and quality challenges stemming from root rot primarily caused by Fusarium solani. Burkholderia arboris PN-1...
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Open AccessMRE11A: a novel negative regulator of human DNA mismatch repair
DNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors, the loss of which is attributed to the development of various types of cancers. Although well characterized, MMR fa...
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Open AccessTAB182 regulates glycolytic metabolism by controlling LDHA transcription to impact tumor radiosensitivity
Metabolic reprogramming, a hallmark of cancer, is closely associated with tumor development and progression. Changes in glycolysis play a crucial role in conferring radiation resistance to tumor cells. How rad...
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Open AccessBacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner
Bacillus cereus is a clinically significant foodborne pathogen that causes severe gastrointestinal and non-gastrointestinal disease. Cereolysin O (CLO) is a putative virulence factor of B. cereus, and its functio...
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Open AccessMTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma
MYCN amplification is an independent poor prognostic factor in patients with high-risk neuroblastoma (NB). Further exploring the molecular regulatory mechanisms in MYCN-amplified NB will help to develop novel ...
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Open AccessLOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer mortality globally. Lymph node metastasis and immunosuppression are main factors of poor prognosis in CRC patients. Lysyl oxidase like 1 (LOXL1), part of th...
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Open AccessCHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma
Currently, there is still a lack of novel and effective drug targets to improve the prognosis of hepatocellular carcinoma (HCC). Additionally, the role of CHEK2 in HCC has not been reported yet. The eQTLgen da...
