28 Result(s)
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Article
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
We identify berberine (BBR), a compound isolated from a Chinese herb, as a new cholesterol-lowering drug. Oral administration of BBR in 32 hypercholesterolemic patients for 3 months reduced serum cholesterol b...
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Open AccessThe cellular source for APOBEC3G's incorporation into HIV-1
Human APOBEC3G (hA3G) has been identified as a cellular inhibitor of HIV-1 infectivity. Viral incorporation of hA3G is an essential step for its antiviral activity. Although the mechanism underlying hA3G virio...
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Open AccessRetraction Note: the cellular source for APOBEC3G's incorporation into HIV-1
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Article
Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells
In this issue, Thomas Kupper and colleagues report that mice deficient for ROR-γ or interleukin-23 (IL-23) receptor showed impaired melanoma growth. Tumor growth inhibition was dependent in part on IL-9 and T ...
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Article
Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis
Osteosarcoma and Ewing’s sarcoma are the two most common primary malignant bone tumors, and findings of prognostic factors are important for clinicians to decide treatment options. High p53 expression has been...
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miR-133b acts as a tumor suppressor and negatively regulates FGFR1 in gastric cancer
MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate protein expression by binding protein-coding mRNAs and repressing translation. Accumulating evidence suggests that miRNAs are inv...
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Polymorphism in PHD1 gene and risk of non-small cell lung cancer in a Chinese population
Hypoxia is a common phenomenon in the development of solid tumors, and hypoxia inducible factor 1 (HIF-1) plays a central role in coordinating the cellular response to hypoxia and in oxygen homeostasis. The pr...
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miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9
Osteosarcoma (OS) has become one of the most common primary malignant tumors in the children and adolescents with a poor prognosis mainly due to high metastasis. A disintegrin and metalloprotease 9 (ADAM-9) pl...
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Common clonal origin of central and resident memory T cells following skin immunization
Following skin immunization a common naïve T cell precursor gives rise to resident and central memory T cells, which mediate rapid and delayed skin immune responses, respectively.
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RETRACTED ARTICLE: MicroRNA-92a promotes growth, metastasis, and chemoresistance in non-small cell lung cancer cells by targeting PTEN
MicroRNA-92a (miR-92a) has been reported to play important roles in tumorigenesis of human various cancers. However, the roles and underlying molecular mechanism of miR-92a in non-small cell lung cancer (NSCLC...
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The overexpression of miR-30a affects cell proliferation of chondrosarcoma via targeting Runx2
MicroRNAs (miRNAs) are emerging as important epigenetic modulators of multiple target genes, leading to abnormal cellular signaling involving cellular proliferation in cancers. Aberrant miRNA expression has be...
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Article
Open AccessMetformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer ...
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Open AccessAddition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis
While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) co...
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Article
Open AccessLipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer
Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is cata...
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Article
Linear ubiquitin chain induces apoptosis and inhibits tumor growth
Ubiquitination of proliferating cell nuclear antigen (PCNA) plays an important role in DNA damage response. Ectopic expression of PCNA fused at either terminus with ubiquitin (Ub) lacking two C-terminal glycin...
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Open AccessInhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions
Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic duc...
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Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative inc...
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Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
In the version of this article originally published, an author was missing from the author list. Alexander J. Lazar should have been included between Jorge M. Blando and James P. Allison. The author has been a...
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Open AccessAutophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells
The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality medi...
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Open AccessHigh glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer
Diabetes is recognized to be a risk factor of pancreatic cancer, but the mechanism has not been fully elucidated. Sterol regulatory element binding protein 1 (SREBP1) is an important transcription factor invol...
