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Article
NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination
Portal vein tumour thrombus (PVTT) is the main pathway of HCC intrahepatic metastasis and is responsible for the poor prognosis of patients with HCC. However, the molecular mechanisms underlying PVTT vascular ...
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Article
Open AccessCirculating cell-free DNA-based methylation patterns for breast cancer diagnosis
Mammography is used to detect breast cancer (BC), but its sensitivity is limited, especially for dense breasts. Circulating cell-free DNA (cfDNA) methylation tests is expected to compensate for the deficiency ...
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Article
Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
In the version of this article originally published, an author was missing from the author list. Alexander J. Lazar should have been included between Jorge M. Blando and James P. Allison. The author has been a...
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Article
Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative inc...
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Article
Common clonal origin of central and resident memory T cells following skin immunization
Following skin immunization a common naïve T cell precursor gives rise to resident and central memory T cells, which mediate rapid and delayed skin immune responses, respectively.
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Article
Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells
In this issue, Thomas Kupper and colleagues report that mice deficient for ROR-γ or interleukin-23 (IL-23) receptor showed impaired melanoma growth. Tumor growth inhibition was dependent in part on IL-9 and T ...
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Article
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
We identify berberine (BBR), a compound isolated from a Chinese herb, as a new cholesterol-lowering drug. Oral administration of BBR in 32 hypercholesterolemic patients for 3 months reduced serum cholesterol b...