43 Result(s)

Article

MS80, a novel sulfated oligosaccharide, inhibits pulmonary fibrosis by targeting TGF-β1 both in vitro and in vivo

The pro-fibrogenic cytokine transforming growth factor-beta 1 (TGF-β1) has attracted much attention for its potential role in the etiology of idiopathic pulmonary fibrosis (IPF). Here, we demonstrate that MS80...

Han-dong Jiang, Hua-shi Guan in Acta Pharmacologica Sinica (2009)

Article

The cellular source for APOBEC3G's incorporation into HIV-1

Human APOBEC3G (hA3G) has been identified as a cellular inhibitor of HIV-1 infectivity. Viral incorporation of hA3G is an essential step for its antiviral activity. Although the mechanism underlying hA3G virio...

**g Ma, **aoyu Li, Jian Xu, Quan Zhang, Zhenlong Liu, **** Jia… in Retrovirology (2011)

Article

Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KKR spatial triad

Sulfated polymannuroguluronate (SPMG), a candidate anti-AIDS drug, inhibited HIV replication and interfered with HIV entry into host T lymphocytes. SPMG has high binding affinity for the transactivating factor...

Yan-lin Wu, **g Ai, **g-ming Zhao, Bing **ong, **ao-jie **n… in Acta Pharmacologica Sinica (2011)

Article

Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes

Berberine (BBR) is a drug with multiple effects on cellular energy metabolism. The present study explored answers to the question of which CYP450 (Cytochrome P450) isoenzymes execute the phase-I transformation...

Yi Li, Gang Ren, Yan-**ang Wang, Wei-Jia Kong… in Journal of Translational Medicine (2011)

Article

Retraction Note: the cellular source for APOBEC3G's incorporation into HIV-1

**g Ma, **aoyu Li, Jian Xu, Quan Zhang, Zhenlong Liu, **** Jia… in Retrovirology (2011)

Article

Identification and characterization of a novel gene, c1orf109, encoding a CK2 substrate that is involved in cancer cell proliferation

In the present study we identified a novel gene, Homo Sapiens Chromosome 1 ORF109 (c1orf109, GenBank ID: NM_017850.1), which encodes a substrate of CK2. We analyzed the regulation mode of the gene, the expression...

Shan-shan Liu, Hong-xia Zheng, Hua-dong Jiang, Jie He… in Journal of Biomedical Science (2012)

Article

Formononetin inhibits enterovirus 71 replication by regulating COX- 2/PGE₂ expression

The activation of ERK, p38 and JNK signal cascade in host cells has been demonstrated to up-regulate of enterovirus 71 (EV71)-induced cyclooxygenase-2 (COX-2)/ prostaglandins E₂ (PGE₂) expression which is essenti...

Huiqiang Wang, Dajun Zhang, Miao Ge, Zhuorong Li, Jiandong Jiang… in Virology Journal (2015)

Article

Common clonal origin of central and resident memory T cells following skin immunization

Following skin immunization a common naïve T cell precursor gives rise to resident and central memory T cells, which mediate rapid and delayed skin immune responses, respectively.

Olivier Gaide, Ryan O Emerson, **aodong Jiang, Nicholas Gulati… in Nature Medicine (2015)

Article

Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters

Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates the extracellular-signal regulated kinase pathway by stabilizin...

**ao-Yang Li, Zhen-**ong Zhao, Min Huang, Ru Feng… in Journal of Translational Medicine (2015)

Article

Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease

We recently demonstrated a positive effect of berberine on nonalcoholic fatty liver disease patients after 16 weeks of treatment by comparing mere lifestyle intervention in type 2 diabetes patients with berber...

**nxia Chang, Zhe Wang, **lan Zhang, Hongmei Yan… in Journal of Translational Medicine (2016)

Article

Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy

The MEK-ERK signaling pathway and autophagy play an important role for enterovirus71(EV71) replication. Inhibition of MEK-ERK signaling pathway and autophagy is shown to impair EV71 replication. Berberine (BBR...

Huiqiang Wang, Ke Li, Linlin Ma, Shuo Wu, ** Hu, Haiyan Yan… in Virology Journal (2017)

Article

A novel benzo-heterocyclic amine derivative N30 inhibits influenza virus replication by depression of Inosine-5’-Monophospate Dehydrogenase activity

Influenza virus is still a huge threat to the world-wide public health. Host inosine-5’- monophosphate dehydrogenase (IMPDH) involved in the synthesis of guanine nucleotides, is known to be a potential target ...

** Hu, Linlin Ma, Huiqiang Wang, Haiyan Yan, Dajun Zhang, Zhuorong Li… in Virology Journal (2017)

Article

Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer ...

Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li… in Molecular Cancer (2017)

Article

3-(2-Chloropropyl amide)-4-methoxy-N-phenylbenzamide inhibits expression of HPV oncogenes in human cervical cancer cell

Human papillomaviruses (HPVs) are the primary causative agents for cervical cancer, and HPV oncoproteins E6 and E7 are known to be the main reason for the onset and maintenance of the malignancies. Therefore, ...

Fang Han, Yan** Li, Qiaoni Lu, Linlin Ma, Huiqiang Wang… in Virology Journal (2017)

Article

Addition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis

While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) co...

**chao Feng, Junqing Xu, Shudong Jiang, Hong Yin, Yan Zhao… in Breast Cancer Research (2017)

Article

Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer

Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is cata...

Liang Zong, Ke Chen, Zhengdong Jiang… in Journal of Experimental & Clinical Cancer … (2017)

Article

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions

Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic duc...

Zhengdong Jiang, Cancan Zhou, Liang Cheng… in Journal of Experimental & Clinical Cancer … (2018)

Article

Visualization-assisted binning of metagenome assemblies reveals potential new pathogenic profiles in idiopathic travelers’ diarrhea

Travelers’ diarrhea (TD) is often caused by enterotoxigenic Escherichia coli, enteroaggregative E. coli, other bacterial pathogens, Norovirus, and occasionally parasites. Nevertheless, standard diagnostic methods...

Qiyun Zhu, Christopher L. Dupont, Marcus B. Jones, Kevin M. Pham… in Microbiome (2018)

Article

Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

In the version of this article originally published, an author was missing from the author list. Alexander J. Lazar should have been included between Jorge M. Blando and James P. Allison. The author has been a...

Yinghong Wang, Diana H. Wiesnoski, Beth A. Helmink… in Nature Medicine (2019)

Article

Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells

The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality medi...

Lijun Liang, Kaiyuan Hui, Chenxi Hu… in Journal of Experimental & Clinical Cancer … (2019)