11 Result(s)
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Article
Open AccessCntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway
Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. Cntnap4, a risk...
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Article
Open AccessPFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation
Cancer cells adopt metabolic reprogramming to promote cell survival under metabolic stress. A key regulator of cell metabolism is AMP-activated protein kinase (AMPK) which promotes catabolism while suppresses ...
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Open AccessTranscriptomic analysis of the testicular fusion in Spodoptera litura
Lepidoptera is one group of the largest plant-feeding insects and Spodoptera litura (Lepidoptera: Noctuidae) is one of the most serious agricultural pests in Asia countries. An interesting and unique phenomenon f...
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GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice
GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. He...
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Open AccessGeneration of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene
The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases (TALENs...
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Article
A novel liquid chromatography tandem mass spectrometry method for simultaneous determination of branched-chain amino acids and branched-chain α-keto acids in human plasma
Branched-chain amino acids (BCAAs) and branched-chain α-keto acids (BCKAs) play significant biological roles as they are involved in protein and neurotransmitter synthesis as well as energy metabolism pathways...
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Microrod structure and properties of Sb-doped Ti/SnO2 anodes prepared by magnetron sputtering
Cyclic voltammetry and chronopotentiometry have been used to study the Sb-doped Ti/SnO2 anodes prepared by magnetron sputtering. The results showed that magnetron sputtering condition influenced the surface morph...
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Two-sided Empirical Bayes test for the exponential family with contaminated data
In this study, the two-sided Empirical Bayes test (EBT) rules for the parameter of continuous one-parameter exponential family with contaminated data (errors in variables) are constructed by a deconvolution ke...
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Article
MiR-200a enhances the migrations of A549 and SK-MES-1 cells by regulating the expression of TSPAN1
MicroRNA-200a (miR-200a) has been reported to regulate tumour progression in several tumours; however, little is known about its role in non-small cell lung cancer cells (NSCLCs). Here, we found that miR-200a ...
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Article
Self-assembly of two-dimensional DNA crystals
Self-assembly of synthetic oligonucleotides into two-dimensional lattices presents a ‘bottom-up’ approach to the fabrication of devices on nanometer scale. We report the design and observation of two-dimension...
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Article
Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord
Transplantation of cellular components of the permissive peripheral nerve environment in some types of spinal cord injury holds great promise to support regrowth of axons through the site of injury. In the pre...
