27 Result(s)
within
Article
**aqing Chen
Life Sciences
-
Article
Open AccessAssociation of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study
Glucose-lowering drug is associated with various cancers, but the causality with gastrointestinal cancer risk is rarely reported. We aimed to explore the causality between them in this Mendelian randomization ...
-
Article
Advisory Editor profile: Daqing Chen
-
Article
Open AccessHepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function
Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9+ hepatocytes in response...
-
Article
Advances in application of circulating tumor DNA in ovarian cancer
Ovarian cancer is the third most common gynecologic cancer worldwide and has the highest mortality rate among gynecologic cancers. Identifying timely and effective biomarkers at different stages of the disease...
-
Article
Open AccessCntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway
Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. Cntnap4, a risk...
-
Article
Open AccessPFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation
Cancer cells adopt metabolic reprogramming to promote cell survival under metabolic stress. A key regulator of cell metabolism is AMP-activated protein kinase (AMPK) which promotes catabolism while suppresses ...
-
Article
Transcriptional regulation of microRNA-126a by farnesoid X receptor in vitro and in vivo
Recent research has indicated the microRNA-126a (miR-126a) is an endothelial cell-specific and highly conserved endogenous small non-coding RNA molecule. It contributes to the vascular integrity and angiogenesis,...
-
Article
Using environmental DNA to detect Hypophthalmichthys molitrix during the spawning period in the Yangtze River
The silver carp, Hypophthalmichthys molitrix, is one of four carps farmed in China, and its natural resources have been critically declining in the middle and upper reaches of the Yangtze River. Here, we applied ...
-
Article
Open AccessTranscriptomic analysis of the testicular fusion in Spodoptera litura
Lepidoptera is one group of the largest plant-feeding insects and Spodoptera litura (Lepidoptera: Noctuidae) is one of the most serious agricultural pests in Asia countries. An interesting and unique phenomenon f...
-
Article
GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice
GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. He...
-
Article
Open AccessGeneration of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene
The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases (TALENs...
-
Article
A novel liquid chromatography tandem mass spectrometry method for simultaneous determination of branched-chain amino acids and branched-chain α-keto acids in human plasma
Branched-chain amino acids (BCAAs) and branched-chain α-keto acids (BCKAs) play significant biological roles as they are involved in protein and neurotransmitter synthesis as well as energy metabolism pathways...
-
Article
Isolation and characterization of twelve microsatellite loci of Leiocassis albomargintus (Rendhal) in the Yangtze River
Leiocassis albomargintus (Rendhal) is endemic to the Yangtze River basin in China. By using the fast isolation by amplified fragment length polymorphism of sequences containing repeats protocol, ...
-
Article
Isolation and characterization of eleven microsatellite loci of Pseudobagrus truncatus in the Yangtze River
Eleven polymorphic microsatellite loci were characterized from a wild population of Pseudobagrus truncatus, an endemic catfish to China, using the fast isolation by amplified fragment length polymorphism of seque...
-
Article
Effects of surgically implanted dummy ultrasonic transmitters on growth, survival and transmitter retention of bighead carp Hypophthalmichthys nobilis
The effects of surgically implanted dummy ultrasonic transmitters on growth, survival and transmitter retention of bighead carp Hypophthalmichthys nobilis were investigated from October to November 2010. Before t...
-
Article
Characterization and cross-species amplification of 19 polymorphic microsatellite loci of Hemibagrus macropterus (Bleeker) in the Yangtze River
Hemibagrus macropterus (Bleeker) is endemic to the upper Yangtze River basin and the Zhujiang River basin in China. By using the fast isolation by amplified fragment length polymorphism of sequen...
-
Article
Effects of surgically implanted dummy ultrasonic transmitters on physiological response of bighead carp Hypophthalmichthys nobilis
The study assessed the effects of surgically implanted dummy ultrasonic transmitters on physiological response of bighead carp Hypophthalmichthys nobilis in April 2011. Before the surgery, 15 blood samples were e...
-
Article
Two-sided Empirical Bayes test for the exponential family with contaminated data
In this study, the two-sided Empirical Bayes test (EBT) rules for the parameter of continuous one-parameter exponential family with contaminated data (errors in variables) are constructed by a deconvolution ke...
-
Article
MiR-200a enhances the migrations of A549 and SK-MES-1 cells by regulating the expression of TSPAN1
MicroRNA-200a (miR-200a) has been reported to regulate tumour progression in several tumours; however, little is known about its role in non-small cell lung cancer cells (NSCLCs). Here, we found that miR-200a ...
-
Article
Characterization and cross-species amplification of 14 polymorphic microsatellite loci in Xenophysogobio boulengeri
The ray-finned fish Xenophysogobio boulengeri is endemic to the upper Yangtze River basin in China. By using the Fast Isolation by Amplified Fragment Length Polymorphism of Sequences Containing repeats protocol, ...
