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GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice

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  1. Article

    Open Access

    Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway

    Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. Cntnap4, a risk...

    Wenlong Zhang, Liuyan Ding, Huaqing Chen, Mengran Zhang, Runfang Ma… in Cell Death & Disease (2023)

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  2. Article

    Open Access

    PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation

    Cancer cells adopt metabolic reprogramming to promote cell survival under metabolic stress. A key regulator of cell metabolism is AMP-activated protein kinase (AMPK) which promotes catabolism while suppresses ...

    Jiaqing Chen, Li Zou, Guang Lu, Oleg Grinchuk, Lei Fang… in Cell Discovery (2022)

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  3. Article

    Open Access

    Transcriptomic analysis of the testicular fusion in Spodoptera litura

    Lepidoptera is one group of the largest plant-feeding insects and Spodoptera litura (Lepidoptera: Noctuidae) is one of the most serious agricultural pests in Asia countries. An interesting and unique phenomenon f...

    Yaqing Chen, Jun Ou, Yucheng Liu, Qiong Wu, Liang Wen, Sichun Zheng… in BMC Genomics (2020)

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  4. Article

    Open Access

    Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene

    The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases (TALENs...

    Yuting Chen, Wenqing Lu, Na Gao, Yi Long, Yanjiao Shao… in Science China Life Sciences (2017)

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