7 Result(s)

Article

Association of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study

Glucose-lowering drug is associated with various cancers, but the causality with gastrointestinal cancer risk is rarely reported. We aimed to explore the causality between them in this Mendelian randomization ...

Yi Yang, Bo Chen, Chongming Zheng, Hao Zeng, Junxi Zhou, Yaqing Chen… in Cell & Bioscience (2024)

Article

Advisory Editor profile: Daqing Chen

Margaret F. Docker, Daqing Chen in Environmental Biology of Fishes (2023)

Article

Hepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function

Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9⁺ hepatocytes in response...

Dan Qin, Rui Wang, **wei Ji, Duo Wang, Yuanyuan Lu, Shiyao Cao… in Cell & Bioscience (2023)

Article

Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway

Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. Cntnap4, a risk...

Wenlong Zhang, Liuyan Ding, Huaqing Chen, Mengran Zhang, Runfang Ma… in Cell Death & Disease (2023)

Article

PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation

Cancer cells adopt metabolic reprogramming to promote cell survival under metabolic stress. A key regulator of cell metabolism is AMP-activated protein kinase (AMPK) which promotes catabolism while suppresses ...

Jiaqing Chen, Li Zou, Guang Lu, Oleg Grinchuk, Lei Fang… in Cell Discovery (2022)

Article

Transcriptomic analysis of the testicular fusion in Spodoptera litura

Lepidoptera is one group of the largest plant-feeding insects and Spodoptera litura (Lepidoptera: Noctuidae) is one of the most serious agricultural pests in Asia countries. An interesting and unique phenomenon f...

Yaqing Chen, Jun Ou, Yucheng Liu, Qiong Wu, Liang Wen, Sichun Zheng… in BMC Genomics (2020)

Article

Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene

The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases (TALENs...

Yuting Chen, Wenqing Lu, Na Gao, Yi Long, Yanjiao Shao… in Science China Life Sciences (2017)