147 Result(s)

Article

Correction: The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Ming Li, Zhongyu **e, Peng Wang, **teng Li, Wenjie Liu, Su’an Tang… in Cell Death & Disease (2024)

Article

Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice

Senescent cell clearance is emerging as a promising strategy for treating age-related diseases. Senolytics are small molecules that promote the clearance of senescent cells; however, senolytics are uncommon an...

Jie Zhang, Pengfei Sun, Zhu** Wu, Jie Wu, Jiali Jia, Haoman Zou… in Cell Death & Disease (2024)

Article

Research progress on morphology and mechanism of programmed cell death

Programmed cell death (PCD) is a basic process of life that is closely related to the growth, development, aging and disease of organisms and is one of the hotspots of life science research today. PCD is a kin...

Yao Chen, **aohua Li, Minfeng Yang, Song-Bai Liu in Cell Death & Disease (2024)

Article

LncRNA IL21-AS1 facilitates tumour progression by enhancing CD24-induced phagocytosis inhibition and tumorigenesis in ovarian cancer

CD24 is overexpressed in various tumours and considered a regulator of cell migration, invasion, and proliferation. Recent studies have found that CD24 on ovarian cancer (OC) and triple-negative breast cancer ...

Jie Liu, Changsheng Yan, Shaohua Xu in Cell Death & Disease (2024)

Article

Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo

During the maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, develo** lymphocytes may undergo malignant transformation and produce B-cell lymphomas. Emer...

Zhaohua Cai, Shao** You, Zhixue Liu, ** Song, Fujie Zhao… in Cell Death & Disease (2024)

Article

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute to therapeutic resistance. Thus, targeting RNA splicing to ...

Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, **aohua Chen, Boyi Yu… in Cell Death & Disease (2024)

Article

Correction: Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma

Chan **ang, Min Zhang, Zhanxian Shang, Shengnan Chen, Jikai Zhao… in Cell Death & Disease (2024)

Article

Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis

Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in lung cancer and...

Yunshang Chen, Yun Zhou, Xue Feng, Zilong Wu, Yongqiang Yang… in Cell Death & Disease (2024)

Article

METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner

Acute lung injury (ALI) as well as its more severe form, acute respiratory distress syndrome (ARDS), frequently leads to an uncontrolled inflammatory response. N⁶-methyladenosine (m⁶A) modification was associated...

Fei Cao, Guojun Chen, Yixin Xu, **ntong Wang, **aole Tang… in Cell Death & Disease (2024)

Article

Carrier systems of radiopharmaceuticals and the application in cancer therapy

Radiopharmaceuticals play a vital role in cancer therapy. The carrier of radiopharmaceuticals can precisely locate and guide radionuclides to the target, where radionuclides kill surrounding tumor cells. Effec...

Taotao Zhang, Huiwen Lei, **aohua Chen, Zhihui Dou, Boyi Yu, Wei Su… in Cell Death Discovery (2024)

Article

Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells

Here, we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation. By excising the natural poly-adenylation (poly-A) signal of target genes and replacing it wit...

Jiawei Shao, Shichao Li, **nyuan Qiu, Jian Jiang, Lihang Zhang… in Cell Research (2024)

Article

Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation

Obesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue and leads to elevated cytokines such as interleukin-1β (IL-1β) in the circulation and ti...

Yang**g Jiang, Min Liang, Long Chen, Jian Wang… in Cellular and Molecular Life Sciences (2023)

Article

Retraction Note: MIR600HG sponges miR-125a-5p to regulate glycometabolism and cisplatin resistance of oral squamous cell carcinoma cells via mediating RNF44

**ngguang Liu, Tengda Zhao, Zhe Yuan, Shaohua Ge in Cell Death Discovery (2023)

Article

Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge of peri-implantation lineage development as well as underlying mechanisms remains obscur...

Zongyong Ai, Baohua Niu, Yu Yin, Lifeng **ang, Gaohui Shi, Kui Duan… in Cell Research (2023)

Article

N-acetyltransferase 10 promotes cutaneous wound repair via the NF-κB-IL-6 axis

Cutaneous wound healing, an integral part for protection of skin barrier, is a complex biological process and intimately associated with keratinocyte migration. However, mechanisms regulating keratinocyte migr...

Ben Wang, ** Zhang, Guo Li, Chenzhong Xu, Langmei Yang, Jie Zhang… in Cell Death Discovery (2023)

Article

A novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation

During meiosis, at least one crossover must occur per homologous chromosome pair to ensure normal progression of meiotic division and accurate chromosome segregation. However, the mechanism of crossover format...

Suixing Fan, Yuewen Wang, Hanwei Jiang, **aohua Jiang, Jianteng Zhou… in Cell Discovery (2023)