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  1. No Access

    Article

    CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway

    Cardiac fibrosis is a detrimental pathological process, which constitutes the key factor for adverse cardiac structural remodeling leading to heart failure and other critical conditions. Circular RNAs (circRNA...

    Dong-ni Ji, Sai-di **, Yuan Jiang, Fei-yong Xu, Shu-wei Fan in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway

    Diabetes-related vascular complications include diabetic cardiovascular diseases (CVD), diabetic nephropathy (DN) and diabetic retinopathy, etc. DN can promote the process of end-stage renal disease. On the ot...

    Ting-feng Zou, Zhi-gang Liu, Pei-chang Cao, Shi-hong Zheng in Acta Pharmacologica Sinica (2023)

  3. No Access

    Article

    Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice

    Chronic administration of methamphetamine (METH) leads to physical and psychological dependence. It is generally accepted that METH exerts rewarding effects via competitive inhibition of the dopamine transport...

    Peng-ju Yan, Zhao-xiang Ren, Zhi-feng Shi, Chun-lei Wan in Acta Pharmacologica Sinica (2022)

  4. No Access

    Article

    Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling

    Neurovascular unit (NVU) is organized multi-cellular and multi-component networks that are essential for brain health and brain homeostasis maintaining. Neurovascular unit dysfunction is the central pathogenes...

    Hong-** Wang, Hai-feng Ran, Yue Yin, **ao-gang Xu in Acta Pharmacologica Sinica (2022)

  5. Article

    Open Access

    Correction to: Predicting global numbers of teleomorphic ascomycetes

    Indunil C. Senanayake, Dhandevi Pem, Achala R. Rathnayaka in Fungal Diversity (2022)

  6. Article

    Open Access

    Predicting global numbers of teleomorphic ascomycetes

    Sexual reproduction is the basic way to form high genetic diversity and it is beneficial in evolution and speciation of fungi. The global diversity of teleomorphic species in Ascomycota has not been estimated....

    Indunil C. Senanayake, Dhandevi Pem, Achala R. Rathnayaka in Fungal Diversity (2022)

  7. No Access

    Article

    Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis

    Metastasis is the main cause of mortality in patients with cancer. Epithelial–mesenchymal transition (EMT), a crucial process in cancer metastasis, is an established target for antimetastatic drug development....

    Cheng-lin Li, Juan Li, Shu-yuan Gong, Meng Huang, Rui Li in Acta Pharmacologica Sinica (2021)

  8. Article

    IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice

    Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeri...

    Bin He, Hai-yan Hu, Tao Tan, Hong Wang, Kao-xiang Sun in Acta Pharmacologica Sinica (2018)

  9. No Access

    Article

    Efficient Using Durian Shell Hydrolysate as Low-Cost Substrate for Bacterial Cellulose Production by Gluconacetobacter xylinus

    Durian is one important tropical fruit with high nutritional value, but its shell is usually useless and considered as waste. To explore the efficient and high-value utilization of this agricultural and food ...

    Mu-Tan Luo, Cheng Zhao, Chao Huang, Xue-Fang Chen in Indian Journal of Microbiology (2017)

  10. No Access

    Article

    The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis

    Exosomes are nanoparticles of endocytic origin, secreted by a myriad of cell populations that are attracting increased attention by virtue of their ability to modulate cell-to-cell communications. They are als...

    Takashi Tomiyama, Guo-**ang Yang, Ming Zhao, Weici Zhang in Cellular & Molecular Immunology (2017)

  11. No Access

    Article

    Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis

    Fibroblast-like synoviocytes (FLSs) contribute to synovial hyperplasia in rheumatoid arthritis (RA). Smoothened (Smo) is a key component of sonic hedgehog (Shh) signaling and contributes to tumor cell prolifer...

    Shang-ling Zhu, Jian-lin Huang, Wei-xiang Peng in Cellular & Molecular Immunology (2017)

  12. Article

    Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

    It is general believed that mitochondrial dysfunction and oxidative stress play critical roles in the pathology of Parkinson's disease (PD). Dihydromyricetin (DHM), a natural flavonoid extracted from Ampelopsis g...

    Zhao-xiang Ren, Ya-fei Zhao, Ting Cao, Xue-chu Zhen in Acta Pharmacologica Sinica (2016)

  13. No Access

    Article

    Preparation of Bacterial Cellulose/Inorganic Gel of Bentonite Composite by In Situ Modification

    To evaluate the possibility of Bacterial cellulose/Inorganic Gel of Bentonite (BC/IGB) composite production using in situ method, the BC/IGB composite was successfully produced by in situ modification of BC in...

    Bo Wang, Gao-xiang Qi, Chao Huang, **ao-Yan Yang in Indian Journal of Microbiology (2016)

  14. Article

    Molecular network-based analysis of Guizhi-Shaoyao-Zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy

    Guizhi-Shaoyao-Zhimu decoction (GSZ), a traditional Chinese medicine (TCM) herbal formula, has been shown effective in the treatment of diabetic peripheral neuropathy (DPN). In this study, network analysis was...

    Ning Zhao, Jian Li, Li Li, Xu-yan Niu, Miao Jiang in Acta Pharmacologica Sinica (2015)

  15. Article

    Herbal prescription Chang'an II repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome

    The herbal prescription Chang'an II is derived from a classical TCM formula Tong-**e-Yao-Fang for the treatment of liver-qi stagnation and spleen deficiency syndrome of irritable bowel syndrome (IBS). In this ...

    Feng-yun Wang, Min Su, Yong-qiu Zheng, **ao-ge Wang, Nan Kang in Acta Pharmacologica Sinica (2015)

  16. Article

    Open Access

    Human papillomavirus prevalence and type-distribution among women in Zhejiang Province, Southeast China: a cross-sectional study

    Human papillomavirus (HPV) infection is the main etiological factor for cervical cancer and premalignant lesions of the cervix. The purposes of the present study were to determine the prevalence of type-specif...

    **ao-**ang Liu, **ng-Li Fan, Yue-** Yu, Lei Ji, Jie Yan in BMC Infectious Diseases (2014)

  17. Article

    Co-activation of nAChR and mGluR induces γ oscillation in rat medial septum diagonal band of Broca slices

    To examine whether co-activation of nAChR and mGluR1 induced γ oscillation (20–60 Hz) in rat medial septum diagonal band of Broca (MSDB) slices.

    Ya-li Wang, Jian-gang Wang, Gao-xiang Ou-yang, **ao-li Li in Acta Pharmacologica Sinica (2014)

  18. Article

    Novel ferrocenyl derivatives exert anti-cancer effect in human lung cancer cells in vitro via inducing G1-phase arrest and senescence

    To investigate the effects of 7 novel 1-ferrocenyl-2-(5-phenyl-1H-1,2,4-triazol-3-ylthio) ethanone derivatives on human lung cancer cells in vitro and to determine the mechanisms of action.

    Ying Li, Han-lin Ma, Lei Han, Wei-yong Liu, Bao-xiang Zhao in Acta Pharmacologica Sinica (2013)

  19. Article

    Effects of nicotine stimulation on spikes, theta frequency oscillations, and spike-theta oscillation relationship in rat medial septum diagonal band Broca slices

    Spiking activities and neuronal network oscillations in the theta frequency range have been found in many cortical areas during information processing. The aim of this study is to determine whether nicotinic a...

    Dong Wen, Ce Peng, Gao-xiang Ou-yang, Zainab Henderson in Acta Pharmacologica Sinica (2013)

  20. No Access

    Article

    Complete genomic sequence analysis reveals a novel fabavirus infecting cucurbits in China

    The complete genome sequence of a cucurbit-infecting fabavirus was determined. Sequence analysis revealed that it had a genomic organization typical of fabaviruses, with genome segment sizes of 5870 nt (RNA-1)...

    Shu-Wei Dong, Hai-Ying **ang, Qiao-**a Shang, Da-Wei Li, Jia-Lin Yu in Archives of Virology (2012)

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