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  1. No Access

    Article

    Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas

    Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various irreversible or reversible BTK inhibitors. However, on-target BTK m...

    Pei-ran Song, Zhi-peng Wan, Ge-ge Huang, Zi-lan Song… in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer

    The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for the treatment of prostate cancer. Herein, we report the identification, optimization, and evaluat...

    **-shan Wu, **ao-yu Luo, Cheng-chang Li, **ao-fan Zhao… in Acta Pharmacologica Sinica (2024)

  3. Article

    Open Access

    Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma

    Esophagogastric junction adenocarcinoma (EJA) lacks serum biomarkers to assist in diagnosis and prognosis. Here, we aimed to evaluate the diagnostic and prognostic value of serum insulin-like growth factor bin...

    Tian-Yan Ding, Yu-Hui Peng, Chao-Qun Hong, Bin-Liang Huang… in Discover Oncology (2022)

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  4. Article

    Open Access

    Risk factors for prolonged preoperative waiting time of intertrochanteric fracture patients undergoing operative treatment

    Intertrochanteric fracture is a common fracture in older adults. We observed the case characteristics of intertrochanteric fracture and analyzed the risk factors for prolonged preoperative waiting time based o...

    Fei Liu, Wen-jie Chang, Xu Wang, Rui Gong, Dao-tong Yuan… in BMC Musculoskeletal Disorders (2022)

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  5. Article

    Open Access

    Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota

    Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO production in the gut microbiota and treat athe...

    Shu-Rong Ma, Qian Tong, Yuan Lin, Li-Bin Pan… in Signal Transduction and Targeted Therapy (2022)

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  6. No Access

    Article

    Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer

    Non-small-cell lung cancer (NSCLC) is the most common malignant lung tumor and is difficult to be eradicated due to its immunosuppressive microenvironment. Chlorin e6 (Ce6)-mediated photodynamic therapy (PDT) ...

    Ting-Ting Yu, **ng-Chun Peng, Mei-Fang Wang… in Journal of Cancer Research and Clinical On… (2022)

  7. Article

    Open Access

    World Congress Integrative Medicine & Health 2017: part two

    Carolyn Ee, Sharmala Thuraisingam… in BMC Complementary and Alternative Medicine (2017)

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