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Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma

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  1. Article

    Open Access

    Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

    The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

    Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li in Signal Transduction and Targeted Therapy (2023)

  2. Article

    Open Access

    Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

    EMERGING-CTONG 1103 showed improved progression-free survival (PFS) with neoadjuvant erlotinib vs. chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell l...

    Wen-Zhao Zhong, Hong-Hong Yan, Ke-Neng Chen in Signal Transduction and Targeted Therapy (2023)

  3. Article

    Open Access

    Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma

    Immune checkpoint blockade resistance narrows the efficacy of cancer immunotherapies, but the underlying mechanism remains elusive. Delineating the inherent mechanisms of anti-PD1 resistance is important to im...

    Jia-Cheng Lu, Peng-Fei Zhang, **ao-Yong Huang in Journal of Hematology & Oncology (2021)

  4. Article

    Open Access

    Development and validation of a novel online calculator for estimating survival benefit of adjuvant transcatheter arterial chemoembolization in patients undergoing surgery for hepatocellular carcinoma

    Although adjuvant transcatheter arterial chemoembolization (TACE) for resected hepatocellular carcinoma (HCC) may improve survival for some patients, identifying which patients can benefit remains challenging....

    Lei Liang, Chao Li, Ming-Da Wang, Hong Wang in Journal of Hematology & Oncology (2021)

  5. Article

    Open Access

    The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update

    The consensus recommendations in 2018 from The Chinese Society of Hematology (CSH) on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation (allo-HSCT) f...

    **ao-hui Zhang, **g Chen, Ming-Zhe Han, He Huang in Journal of Hematology & Oncology (2021)

  6. Article

    Open Access

    Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

    Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...

    Huijie Bian, Zhao-Hui Zheng, Ding Wei in Signal Transduction and Targeted Therapy (2021)

  7. Article

    Open Access

    Association of genetic and immuno-characteristics with clinical outcomes in patients with RET-rearranged non-small cell lung cancer: a retrospective multicenter study

    Rearranged during transfection (RET) has been proven to be a tumorigenic target in non-small cell lung cancers (NSCLCs). In RET-rearranged NSCLCs, molecular features and their impact on prognosis were not well il...

    Chang Lu, **ao-Rong Dong, Jun Zhao, Xu-Chao Zhang in Journal of Hematology & Oncology (2020)