10 Result(s)

Article

Author Correction: Pharmacokinetics, mass balance, and metabolism of [¹⁴C]vicagrel, a novel irreversible P2Y₁₂ inhibitor in humans

Yuan-dong Zheng, Hua Zhang, Yan Zhan, Yi-cong Bian, Sheng Ma… in Acta Pharmacologica Sinica (2023)

Article

Effects of gene polymorphisms in the endoplasmic reticulum stress pathway on clinical outcomes of chemoradiotherapy in Chinese patients with nasopharyngeal carcinoma

There is considerable inter-individual variabil¬ity in chemoradiotherapy responses in nasopharyngeal carcinoma (NPC) patients receiv¬ing the same or similar treatment protocols. In this study we evaluated the ...

**ao-bin Guo, Wan-le Ma, Li-juan Liu, Yu-ling Huang… in Acta Pharmacologica Sinica (2017)

Article

Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression

Aconiti Lateralis Radix Preparata is a traditional Chinese medicine used to treat chronic arthritis and is highly effective against rheumatoid arthritis. However, the effects of aconine, a derivative of aconitum ...

**ang-zhou Zeng, Long-gang He, Song Wang, Keng Wang… in Acta Pharmacologica Sinica (2016)

Article

Cytokine responses and correlations thereof with clinical profiles in children with enterovirus 71 infections

Severe complications associated with EV71 infections caused many infants death. However, the pathogenesis of EV71 infection in the severe cases remained poorly understood.

Ning Ye, Xun Gong, Li-li Pang, Wen-juan Gao, Ya-ting Zhang… in BMC Infectious Diseases (2015)

Article

Molecular network-based analysis of Guizhi-Shaoyao-Zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy

Guizhi-Shaoyao-Zhimu decoction (GSZ), a traditional Chinese medicine (TCM) herbal formula, has been shown effective in the treatment of diabetic peripheral neuropathy (DPN). In this study, network analysis was...

Ning Zhao, Jian Li, Li Li, Xu-yan Niu, Miao Jiang… in Acta Pharmacologica Sinica (2015)

Article

Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation

Sinomenine (SIN) is an alkaloid found in the roots and stems of Sinomenium acutum, which has been used to treat rheumatic arthritis in China and Japan. In this study we investigated the effects of SIN on osteocla...

Long-gang He, **ang-lian Li, **ang-zhou Zeng, Heng Duan… in Acta Pharmacologica Sinica (2014)

Article

Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5

The mitotic kinesin Eg5 plays a critical role in bipolar spindle assembly, and its inhibitors have shown impressive anticancer activity in preclinical studies. This study was undertaken to investigate the effe...

**ao-dong Sun, **ng-juan Shi, **ao-ou Sun, You-guang Luo… in Acta Pharmacologica Sinica (2011)

Article

Apoptosis induced by diallyl disulfide in human breast cancer cell line MCF-7

To investigate the effect of diallyl disulfide (DADS), a component of garlic, on apoptosis in human mammary cancer cell line (MCF-7) and its mechanisms.

**ao-yong Lei, Shu-qiong Yao, Xu-yu Zu, Ze-xiang Huang… in Acta Pharmacologica Sinica (2008)

Article

Comparative proteomic analysis of human osteosarcoma and SV40-immortalized normal osteoblastic cell lines

Comparative proteomics provide a powerful approach in screening for alterations in protein levels and post-translational modifications that are associated with tumors. In the present study, we aimed to identif...

Qian-chen Guo, **g-nan Shen, Song **, ** Wang, Gang Huang… in Acta Pharmacologica Sinica (2007)

Article

Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro

To examine the insulin sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative YY20 in insulin-sensitive cell lines.

Hao-shu Wu, Juan-hong Yu, Ying-yin Li, Yu-she Yang… in Acta Pharmacologica Sinica (2007)