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Human Bcl-2 activates ERK signaling pathway to regulate activating protein-1, lens epithelium-derived growth factor and downstream genes

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  1. Article

    Open Access

    Sulfated alginate oligosaccharide exerts antitumor activity and autophagy induction by inactivating MEK1/ERK/mTOR signaling in a KSR1-dependent manner in osteosarcoma

    Alginate oligosaccharide (AOS) has the function to inhibit tumor progression and the sulfated modification can enhance the antitumor activity. To date, the function and mechanism of sulfated AOS (AOS-SO4) in tumo...

    Zhen Pan, **ao-juan Wei, Shi-jie Li, Hua Guo, Zhao-hui Li, Ke-ke Zhang… in Oncogenesis (2022)

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  2. Article

    Open Access

    Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer

    Overcoming local immunosuppression is critical for immunotherapy to produce robust anti-tumor responses. Myeloid-derived suppressor cells (MDSCs) are key regulators of immunosuppressive networks and promote tu...

    **g Chen, Hong-Wei Sun, Yan-Yan Yang… in Signal Transduction and Targeted Therapy (2021)

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