212 Result(s)

Article

Evaluation of 2 celecoxib derivatives: analgesic effect and selectivity to cyclooxygenase-2/1

To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects on cyclooxygenase (COX).

Zhi-hong Lu, **ao-yun **ong, Bang-le Zhang, Guo-cheng Lin… in Acta Pharmacologica Sinica (2005)

Article

Status of Cellular Rather Than Humoral Immunity is Correlated with Clinical Outcome of Enterovirus 71

We valuated specific cellular and humoral immune response of cases of enterovirus 71 (EV71) infection and correlated immune response with clinical outcome. After obtaining informed consent, we enrolled 30 EV71...

Luan-Yin Chang, Chao A Hsiung, Chun-Yi Lu, Tzou-Yien Lin… in Pediatric Research (2006)

Article

Disease burden and related medical costs of rotavirus infections in Taiwan

The disease burden and associated medical costs of rotavirus infections in inpatient and outpatient sectors in Taiwan were examined in anticipation of the availability of new rotavirus vaccines.

Chun-Yi Lu, Tsai-Ling Lauderdale, Yin-Hua Fang, Chung-Yi Wang… in BMC Infectious Diseases (2006)

Article

Identification of human dopamine receptors agonists from Chinese herbs

To find human dopamine receptors, especially D1-like receptor specific agonists from Chinese herbs as potential antihypertension drug leads.

Yi-lin Zhang, Hai-qing Zhang, **ao-yu Liu, Shi-neng Hua… in Acta Pharmacologica Sinica (2007)

Article

Fibrinogen interaction of CHO cells expressing chimeric αIIb/αvβ3 integrin

The molecular mechanisms of the affinity regulation of αvβ3 integrin are important in tumor development, wound repairing, and angiogenesis. It has been established that the cytoplasmic domains of αvβ3 integrin...

Juan-juan Chen, **ao-yu Su, **ao-dong **, Li-** Lin… in Acta Pharmacologica Sinica (2008)

Article

The epidemiology of acute respiratory distress syndrome in pediatric intensive care units in China

To assess the incidence of, predisposing factors for, and the rates and relative risks of mortality from acute respiratory distress syndrome (ARDS) in pediatric patients.

Wen-Liang Yu, Zhu-** Lu, Ying Wang, Li-** Shi, Feng-Wu Kuang… in Intensive Care Medicine (2009)

Article

Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin

Hepatic glycogen phosphorylase (GP) and glucose-6-phosphatase (G6Pase) play an important role in the control of blood glucose homeostasis and are proposed to be potential targets for anti-diabetic drugs. Genip...

Shao-yu Wu, Guang-fa Wang, Zhong-qiu Liu, **-jun Rao, Lin Lü… in Acta Pharmacologica Sinica (2009)

Article

Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells

Exocytosis of endothelial Weibel-Palade bodies, which contain von Willebrand factor (VWF), P-selectin and other modulators, plays an important role in both inflammation and thrombosis. The present study invest...

Guang-fa Wang, Shao-yu Wu, **-jun Rao, Lin Lü, Wei Xu… in Acta Pharmacologica Sinica (2009)

Article

Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice

Liver resection is a widely accepted treatment for hepatocellular carcinoma (HCC). Our previous clinical study showed that the rate of palliative resection was 34.0% (1958-2008, 2754 of 8107). However, the inf...

**u-Yan Huang, Zi-Li Huang, Lu Wang, Yong-Hua Xu, **n-Yu Huang, Kai-**ng Ai… in BMC Cancer (2010)

Article

Antiangiogenic effects of pazopanib in xenograft hepatocellular carcinoma models: evaluation by quantitative contrast-enhanced ultrasonography

Antiangiogenesis is a promising therapy for advanced hepatocellular carcinoma (HCC), but the effects are difficult to be evaluated. Pazopanib (GW786034B) is a pan-vascular endothelial growth factor receptor in...

**ao-Dong Zhu, Ju-Bo Zhang, Pei-Li Fan, Yu-Quan **ong, Peng-Yuan Zhuang… in BMC Cancer (2011)

Article

Construction and genetic analysis of murine hepatitis virus strain A59 Nsp16 temperature sensitive mutant and the revertant virus

Coronaviruses (CoVs) are generally associated with respiratory and enteric infections and have long been recognized as important pathogens of livestock and companion animals. Mouse hepatitis virus (MHV) is a w...

Guo-hui Chang, Bao-jun Luo, Pin Lu, Lei Lin, **ao-yan Wu, **g Li… in Virologica Sinica (2011)

Article

Functional characterization of cellulases identified from the cow rumen fungus Neocallimastix patriciarum W5 by transcriptomic and secretomic analyses

Neocallimastix patriciarum is one of the common anaerobic fungi in the digestive tracts of ruminants that can actively digest cellulosic materials, and its cellulases have great potential for hydrolyzing cellulos...

Tzi-Yuan Wang, Hsin-Liang Chen, Mei-Yeh J Lu, Yo-Chia Chen… in Biotechnology for Biofuels (2011)

Article

The mechanisms and possible significance of upregulation of stomatin expression by hypoxia and/or glucocorticoids

Ji-Cheng Chen, Hao-Yu Cai, Yan Wang, Yuan-Yuan Ma, Liang-Nian Song… in Genome Biology (2011)

Article

Immobilization of enzyme and antibody on ALD-HfO₂-EIS structure by NH₃ plasma treatment

Thin hafnium oxide layers deposited by an atomic layer deposition system were investigated as the sensing membrane of the electrolyte-insulator-semiconductor structure. Moreover, a post-remote NH₃ plasma treatmen...

I-Shun Wang, Yi-Ting Lin, Chi-Hsien Huang, Tseng-Fu Lu… in Nanoscale Research Letters (2012)

Article

High codon adaptation in citrus tristeza virus to its citrus host

Citrus tristeza virus (CTV), a member of the genus Closterovirus within the family Closteroviridae, is the causal agent of citrus tristeza disease. Previous studies revealed that the negative selection, RNA recom...

**ao-fei Cheng, **ao-yun Wu, Hui-zhong Wang, Yu-qiang Sun… in Virology Journal (2012)

Article

Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau

While a number of genome-wide association studies have identified microtubule-associated protein tau as a strong risk factor for Parkinson’s disease (PD), little is known about the mechanism through which huma...

Ting-Han Wu, Yu-Ning Lu, Chia-Lung Chuang, Chia-Lin Wu… in Acta Neuropathologica (2013)

Article

The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways

Recent studies have indicated that the expression of endothelin A receptor (ETAR) and chemokine receptor 4 (CXCR4) could be used as an indicator of the metastatic potential of nasopharyngeal carcinoma (NPC). T...

Dong-Hua Luo, Qiu-Yan Chen, Huai Liu, Li-Hua Xu… in Journal of Translational Medicine (2013)

Article

Analysis on genetic diversification and heterosis in autotetraploid rice

Polyploidization has played an important role in plant evolution and is a pathway for plants to increase genetic diversification and to get higher heterosis comparing with that of diploid does. This study was ...

**-Wen Wu, Chao-Yue Hu, Muhammad Qasim Shahid, Hai-Bin Guo, Yu-**ang Zeng… in SpringerPlus (2013)

Article

The study of the Oxytropis kansuensis-induced apoptotic pathway in the cerebrum of SD rats

Locoweeds cause significant livestock poisoning and economic loss all over the world. Animals can develop locoism, a chronic neurological disease, after grazing on locoweeds. Oxytropis kansuensis is a variety of ...

Hao Lu, Liang Zhang, Shan-shan Wang, Wen-long Wang, Bao-yu Zhao in BMC Veterinary Research (2013)

Article

Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons

Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the s...

Chung-Yu Huang, Ying-Ling Chen, Allen H Li, Juu-Chin Lu… in Journal of Neuroinflammation (2014)