17 Result(s)
within
Cancer Research
**ao-Shu Jiang
Article
-
Article
Open AccessEpigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets
Autophagy is a conserved lysosomal degradation pathway where cellular components are dynamically degraded and re-processed to maintain physical homeostasis. However, the physiological effect of autophagy appea...
-
Article
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the...
-
Article
Open AccessACE2-independent infection of T lymphocytes by SARS-CoV-2
SARS-CoV-2 induced marked lymphopenia in severe patients with COVID-19. However, whether lymphocytes are targets of viral infection is yet to be determined, although SARS-CoV-2 RNA or antigen has been identifi...
-
Article
Open AccessCEOP/IVE/GDP alternating regimen compared with CEOP as the first-line therapy for newly diagnosed patients with peripheral T cell lymphoma: results from a phase 2, multicenter, randomized, controlled clinical trial
Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP)/CHOP-like chemotherapy is widely used in peripheral T cell lymphoma (PTCL). Here we conducted a phase 2, multicenter, randomized, controlled ...
-
Article
Fine-map** of 150 breast cancer risk regions identifies 191 likely target genes
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining asso...
-
Article
Open AccessGPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway
Gastric cancer is one of the deadliest malignant tumours, with a high incidence in China, and is regulated by aberrantly overexpressed oncogenes. However, existing therapies are insufficient to meet patients’ ...
-
Article
Open AccessExpression of AE1/p16 promoted degradation of AE2 in gastric cancer cells
Human anion exchanger 1 and 2 (AE1 and AE2) mediate the exchange of Cl−/HCO3 − across the plasma membrane and regulate intracellular pH (pHi). AE1 is specifically expressed on the surfa...
-
Article
Open AccessMyeloid-derived suppressor cells inhibit T cell proliferation in human extranodal NK/T cell lymphoma: a novel prognostic indicator
The expansion of myeloid-derived suppressor cells (MDSCs) and its correlation with advanced disease stage have been shown in solid cancers. Here, we investigated the functional features and clinical significan...
-
Article
PPM1D overexpression predicts poor prognosis in non-small cell lung cancer
It has been reported that protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) plays an important role in cancer tumorigenesis. However, the clinical and functional significance of PPM1D expression has not been c...
-
Article
Open AccessSPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway
Gallbladder cancer (GBC) is a leading cause of cancer-related death worldwide, and its prognosis remains poor, with 5-year survival of approximately 5%. In this study, we analyzed the involvement of a novel pr...
-
Article
Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
Nat. Genet. 42, 759–763 (2010); published online 22 August 2010; corrected after print 27 August 2014 In contrast to the version of this article initially published, the authors now find no evidence to support...
-
Article
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and a...
-
Article
C-type natriuretic peptide inhibiting vascular calcification might involve decreasing bone morphogenic protein 2 and osteopontin levels
Vascular calcification (VC) is highly associated with increased morbidity and mortality in patients with advanced chronic kidney disease. Paracrine/autocrine factors such as vasoactive peptides are involved i...
-
Article
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously rep...
-
Article
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population
Xue-Jun Zhang, Zhi-Rong Yao and colleagues report a genome-wide association study for atopic dermatitis in the Chinese Han population. They identified two new susceptibility loci at 5q22 and 20q13.
-
Article
Association analyses identify six new psoriasis susceptibility loci in the Chinese population
Xue-Jun Zhang and colleagues report genome-wide association analyses identifying six new susceptibility loci in the Chinese population.
-
Article
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1
Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.
