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  1. Article

    Open Access

    Induction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis

    Despite limited efficacy of immunotherapy for advanced non-small-cell lung cancer (NSCLC) with driver mutations, whether neoadjuvant immunotherapy could be clinically valuable in those patients warrants furthe...

    Chao Zhang, Hua-Fei Chen, Shi Yan, Lin Wu, Li-Xu Yan in npj Precision Oncology (2022)

  2. Article

    Open Access

    Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

    Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still...

    Qing-zhang Tuo, Yu Liu, in Signal Transduction and Targeted Therapy (2022)

  3. Article

    Open Access

    Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

    It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...

    Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu in Signal Transduction and Targeted Therapy (2021)

  4. Article

    Open Access

    Laparoscopic versus open pancreatic resection for ductal adenocarcinoma: separate propensity score matching analyses of distal pancreatectomy and pancreaticoduodenectomy

    Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Currently, laparoscopic pancreatic resection (LPR) is extensively applied to treat benign and low-grade diseases relat...

    Ke Chen, Yu Pan, Chao-jie Huang, Qi-long Chen, Ren-chao Zhang, Miao-zun Zhang in BMC Cancer (2021)

  5. Article

    Open Access

    VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment

    The acidic tumor microenvironment provides an energy source driving malignant tumor progression. Adaptation of cells to an acidic environment leads to the emergence of cancer stem cells. The expression of the ...

    Pei-Shan Hu, Ting Li, **-Fei Lin in Signal Transduction and Targeted Therapy (2020)

  6. Article

    Open Access

    Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer

    The expression of novel oncogenic kinase (NOK), a member of the protein tyrosine kinase (PTK) family, has been observed in several human malignancies including non-small cell lung cancer (NSCLC). However, the ...

    Peng Chen, Wei-Miao Li, Qiang Lu, Jian Wang, **ao-Long Yan, Zhi-Pei Zhang in BMC Cancer (2014)