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  1. Article

    Open Access

    Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

    Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still...

    Qing-zhang Tuo, Yu Liu, in Signal Transduction and Targeted Therapy (2022)

  2. Article

    Open Access

    Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

    It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...

    Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu in Signal Transduction and Targeted Therapy (2021)

  3. Article

    Open Access

    VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment

    The acidic tumor microenvironment provides an energy source driving malignant tumor progression. Adaptation of cells to an acidic environment leads to the emergence of cancer stem cells. The expression of the ...

    Pei-Shan Hu, Ting Li, **-Fei Lin in Signal Transduction and Targeted Therapy (2020)