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  1. Article

    Open Access

    Polyurethane-based three-dimensional printing for biological mesh carriers

    Repair and reconstruction of the myopectineal orifice area using meshes is the mainstay of surgical treatment of inguinal hernias. However, the limitations of existing meshes are becoming increasingly evident ...

    Feng Wang, Lin Hou, Yan-Hui Shan, Zhen-Su Li, **ao-Feng Yang in Scientific Reports (2024)

  2. Article

    Open Access

    Prediction models combining zonulin, LPS, and LBP predict acute kidney injury and hepatorenal syndrome–acute kidney injury in cirrhotic patients

    The development of acute kidney injury (AKI) and hepatorenal syndrome–acute kidney injury (HRS–AKI) in cirrhosis has been associated with intestinal barrier dysfunction and gut-kidney crosstalk. We use the rel...

    Yi-Hsuan Lin, Nai-Rong Kuo, Hsiao-Chin Shen, Yun-Chien Chang in Scientific Reports (2023)

  3. Article

    Open Access

    Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver

    Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for...

    Heng Lin, Yen-Sung Huang, Jean-Michel Fustin, Masao Doi in Nature Communications (2021)

  4. Article

    Open Access

    Assessment of histologic prognostic factors of resectable rectal cancer: comparison of diagnostic performance using various apparent diffusion coefficient parameters

    This study is to investigate optimum apparent diffusion coefficient (ADC) parameter for predicting lymphovascular invasion (LVI), lymph node metastasis (LNM) and histology type in resectable rectal cancer. 58 ...

    Hang Li, Guang-wen Chen, Yi-Sha Liu, Hong Pu, Long-lin Yin in Scientific Reports (2020)

  5. Article

    Open Access

    Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

    In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is...

    **g**g Liu, Wendy J. C. Prager - van der Smissen in Scientific Reports (2020)

  6. Article

    Open Access

    CoA synthase regulates mitotic fidelity via CBP-mediated acetylation

    The temporal activation of kinases and timely ubiquitin-mediated degradation is central to faithful mitosis. Here we present evidence that acetylation controlled by Coenzyme A synthase (COASY) and acetyltransf...

    Chao-Chieh Lin, Mayumi Kitagawa, **aohu Tang, Ming-Hsin Hou in Nature Communications (2018)

  7. Article

    Open Access

    Intravoxel incoherent motion diffusion-weighted imaging for discriminating the pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

    To investigate the usefulness of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in discriminating the pathological complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) in locally...

    Wen Lu, Hou **g, Zhou Ju-Mei, Nie Shao-Lin, Cao Fang, Yu **ao-** in Scientific Reports (2017)

  8. Article

    Open Access

    High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries

    Immunotoxins are an important class of antibody-based therapeutics. The potency of the immunotoxins depends on the antibody fragments as the guiding modules targeting designated molecules on cell surfaces. Pha...

    Shin-Chen Hou, Hong-Sen Chen, Hung-Wei Lin, Wei-Ting Chao in Scientific Reports (2016)

  9. Article

    Open Access

    Correction: Corrigendum: Growth of semiconducting single-wall carbon nanotubes with a narrow band-gap distribution

    Nature Communications 7: Article number: 11160 (2016); Published 30 March 2016; Updated 27 April 2016 This Article contains an error in Fig. 6. In Fig. 6a, the units on the y-axis should be ‘μA’ not ‘mA’.

    Feng Zhang, Peng-**ang Hou, Chang Liu, Bing-Wei Wang, Hua Jiang in Nature Communications (2016)

  10. Article

    Open Access

    Growth of semiconducting single-wall carbon nanotubes with a narrow band-gap distribution

    The growth of high-quality semiconducting single-wall carbon nanotubes with a narrow band-gap distribution is crucial for the fabrication of high-performance electronic devices. However, the single-wall carbon...

    Feng Zhang, Peng-**ang Hou, Chang Liu, Bing-Wei Wang, Hua Jiang in Nature Communications (2016)

  11. Article

    Open Access

    Functioning free gracilis transfer to reconstruct elbow flexion and quality of life in global brachial plexus injured patients

    In the study, the functional recovery and relative comprehensive quality of life of cases of global brachial plexus treated with free functioning muscle transfers were investigated. Patients who received funct...

    Yi Yang, Jian-Tao Yang, Guo Fu, **ang-Ming Li, Ben-Gang Qin, Yi Hou in Scientific Reports (2016)

  12. Article

    Open Access

    Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens

    Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this im...

    Hong-Sen Chen, Shin-Chen Hou, Jhih-Wei Jian, King-Siang Goh in Scientific Reports (2015)

  13. Article

    Open Access

    Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells

    Mesenchymal stem cells (MSCs) are highly plastic cells that are able to transdifferentiate or dedifferentiate under appropriate conditions. In the present study, we reported here that after in vitro induction of ...

    Yunfeng Rui, Liangliang Xu, Rui Chen, Ting Zhang, Sien Lin in Scientific Reports (2015)

  14. Article

    Open Access

    Genome of the Chinese tree shrew

    Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...

    Yu Fan, Zhi-Yong Huang, Chang-Chang Cao, Ce-Shi Chen in Nature Communications (2013)