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  1. Article

    Open Access

    Low muscle density in children with osteogenesis imperfecta using opportunistic low-dose chest CT: a case-control study

    The aim of the study was to investigate the muscle differences in children with osteogenesis imperfecta (OI) using opportunistic low-dose chest CT and to compare different methods for the segmentation of muscl...

    Yi Yuan, Yun-feng Xu, Chao Feng, Yan-dong Liu in BMC Musculoskeletal Disorders (2024)

  2. No Access

    Article

    Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway

    Hypertensive cerebrovascular remodeling involves the enlargement of vascular smooth muscle cells (VSMCs), which activates volume-regulated Cl channels (VRCCs). The leucine-rich repeat-containing family 8 A (LRRC...

    Feng-ting Lu, Cheng-cui Huang, Wen-yi Lai, Gui-yong Yang in Acta Pharmacologica Sinica (2024)

  3. Article

    Open Access

    Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial

    This study aims to assess the efficacy and safety of Qingpeng ointment (QPO), a Tibetan medicine for alleviating symptoms in individuals with acute gouty arthritis (AGA).

    Ya-xi Shang, Shu-feng Wei, Ke-peng Yang in BMC Complementary Medicine and Therapies (2024)

  4. Article

    Open Access

    Safety and Effectiveness of Baricitinib in Chinese Patients with Moderate-to-Severe Rheumatoid Arthritis: 24-Week Results from a Post-Marketing Safety Study

    Baricitinib, a JAK1/JAK2 inhibitor, is approved for treatment of moderate-to-severe rheumatoid arthritis (RA) in China. This single-arm, prospective, multi-center, post-marketing safety study (PMSS) evaluated ...

    Chan-yuan Wu, Qian Wang, Jian Shi, **u-ying Zhang, Rong Du in Rheumatology and Therapy (2023)

  5. No Access

    Article

    Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway

    Diabetes-related vascular complications include diabetic cardiovascular diseases (CVD), diabetic nephropathy (DN) and diabetic retinopathy, etc. DN can promote the process of end-stage renal disease. On the ot...

    Ting-feng Zou, Zhi-gang Liu, Pei-chang Cao, Shi-hong Zheng in Acta Pharmacologica Sinica (2023)

  6. Article

    Open Access

    The Role of CCL3 in the Pathogenesis of Rheumatoid Arthritis

    Rheumatoid arthritis (RA) is a chronic autoimmune disease of unexplained causes. Its pathological features include synovial tissue hyperplasia, inflammatory cell infiltration in joint cavity fluid, cartilage ...

    Ying-Li Yang, **ao-Feng Li, Biao Song, Sha Wu, Yuan-Yuan Wu in Rheumatology and Therapy (2023)

  7. No Access

    Article

    Clinical study of transcranial sonography image characteristics in patients with obstructive sleep apnea

    This study aimed to explore the relationship between patients with obstructive sleep apnea (OSA) from subgroups of varying severity and substantia nigra (SN) hyperechogenicity as well as cerebral blood flow de...

    Qing-yuan Liu, Min Yang, Yu-**g Sheng, **ao-fang Chen in Sleep and Breathing (2023)

  8. No Access

    Article

    GDF11 promotes wound healing in diabetic mice via stimulating HIF-1ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization

    Non-healing diabetic wounds (DW) are a serious clinical problem that remained poorly understood. We recently found that topical application of growth differentiation factor 11 (GDF11) accelerated skin wound he...

    Ying Zhang, Yi-yuan Zhang, Zhen-wei Pan, Qing-qi Li in Acta Pharmacologica Sinica (2023)

  9. Article

    Open Access

    Acceptance and attitude towards the traditional chinese medicine among asymptomatic COVID-19 patients in Shanghai Fangcang hospital

    The Coronavirus Disease 2019 (COVID-19) has brought severe damage to global health and socioeconomics. In China, traditional Chinese medicine (TCM) is the most important complementary and alternative medicine ...

    Bo Pan, Hong-wei Yin, Yue Yu, **ng **ang in BMC Complementary Medicine and Therapies (2023)

  10. No Access

    Article

    PPAR-γ alleviates the inflammatory response in TNF-α-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis

    Rheumatoid arthritis (RA) is characterized by synovial inflammation, synoviocyte expansion and damage to cartilage and bone. We recently reported that peroxisome proliferator-activated receptor (PPAR)-γ inhibi...

    **ao-feng Li, Shu-qin Yin, Hao Li, Ying-li Yang, **n Chen in Acta Pharmacologica Sinica (2023)

  11. Article

    Open Access

    MiR-30c-1-3p targets matrix metalloproteinase 9 involved in the rupture of abdominal aortic aneurysms

    Abdominal aortic aneurysm (AAA) can be fatal if ruptured, but there is no predictive biomarker. Our aim was to evaluate the prognostic potential of microRNAs (miRNAs/miRs) in an AAA mouse model and patients wi...

    Lin Yang, Hong-Gang Sui, Meng-Meng Wang, Jia-Yin Li in Journal of Molecular Medicine (2022)

  12. Article

    Open Access

    A finite element model of the shoulder: application to the changes of biomechanical environment induced by postoperative malrotation of humeral shaft fracture

    The humerus fracture is one of the most commonly occurring fractures. In this research, we attempted to evaluate and compare the extent of malrotation and biomechanical environment after surgical treatment of ...

    Cheng Wang, **ao-yuan Ma, Lin-tao Lu, Zheng Guo in BMC Musculoskeletal Disorders (2022)

  13. No Access

    Article

    Kanglexin delays heart aging by promoting mitophagy

    Heart aging is characterized by structural and diastolic dysfunction of the heart. However, there is still no effective drug to prevent and treat the abnormal changes in cardiac function caused by aging. Here,...

    Hui-min Li, **n Liu, Zi-yu Meng, Lei Wang, Li-min Zhao in Acta Pharmacologica Sinica (2022)

  14. Article

    Open Access

    Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

    Messenger RNA (mRNA) vaccine technology has shown its power in preventing the ongoing COVID-19 pandemic. Two mRNA vaccines targeting the full-length S protein of SARS-CoV-2 have been authorized for emergency u...

    Hui Zhao, Tie-Cheng Wang, **ao-Feng Li in Signal Transduction and Targeted Therapy (2021)

  15. Article

    Correction to: Progression-free survival at 24 months and subsequent survival of patients with extranodal NK/T-cell lymphoma: a China Lymphoma Collaborative Group (CLCG) study

    Yong Yang, Ying Wang, **n Liu, **a He, Li-Ling Zhang, Gang Wu, Bao-Lin Qu in Leukemia (2021)

  16. Article

    Open Access

    Low value of whole-body dual-modality [18f]fluorodeoxyglucose positron emission tomography/computed tomography in primary staging of stage I–II nasopharyngeal carcinoma: a nest case-control study

    The value of using PET/CT for staging of stage I–II NPC remains unclear. Hence, we aimed to investigate the survival benefit of PET/CT for staging of early-stage NPC before radical therapy.

    Bei-Bei **ao, Qiu-Yan Chen, Xue-Song Sun, Ji-Bin Li, Dong-hua Luo in European Radiology (2021)

  17. Article

    Open Access

    Progression-free survival at 24 months and subsequent survival of patients with extranodal NK/T-cell lymphoma: a China Lymphoma Collaborative Group (CLCG) study

    Limited evidence supports the use of early endpoints to evaluate the success of initial treatment of extranodal NK/T-cell lymphoma (ENKTCL) in the modern era. We aim to analyze progression-free survival at 24 ...

    Yong Yang, Ying Wang, **n Liu, **a He, Li-Ling Zhang, Gang Wu, Bao-Lin Qu in Leukemia (2021)

  18. No Access

    Article

    Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway

    Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent bilateral oophorectomy. Previous evidence suggests that puera...

    Ning Hou, Yin Huang, Shao-ai Cai, Wen-chang Yuan, Li-rong Li in Acta Pharmacologica Sinica (2021)

  19. Article

    Open Access

    Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making

    Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostl...

    Si-Ye Chen, Yong Yang, Shu-Nan Qi, Ying Wang, Chen Hu, **a He, Li-Ling Zhang in Leukemia (2021)

  20. Article

    Effectiveness of Lifestyle and Drug Intervention on Hypertensive Patients: a Randomized Community Intervention Trial in Rural China

    Strict medication guidance and lifestyle interventions to manage blood pressure (BP) in hypertensive patients are typically difficult to follow.

    **g **ao MD, PhD, Wen-Long Ren MD, PhD in Journal of General Internal Medicine (2020)

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