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Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway

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  1. Article

    Carvacrol protects neuroblastoma SH-SY5Y cells against Fe2+-induced apoptosis by suppressing activation of MAPK/JNK-NF-κB signaling pathway

    Carvacrol (2-methyl-5-isopropylphenol), a phenolic monoterpene in the essential oils of the genera Origanum and Thymus, has been shown to exert a variety of therapeutic effects. Here we examined whether carvacrol...

    Zhen-wen Cui, Zheng-xing **e, Bao-feng Wang, Zhi-hong Zhong in Acta Pharmacologica Sinica (2015)

  2. Article

    Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression

    Aquaporins (AQPs) are the water-channels that play important roles in brain water homeostasis and in cerebral edema induced by brain injury. In this study we investigated the relationship between AQPs and a ne...

    Bao-feng Wang, Zhen-wen Cui, Zhi-hong Zhong, Yu-hao Sun in Acta Pharmacologica Sinica (2015)

  3. Article

    Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease

    Protopanaxtriol (Ppt) is extracted from Panax ginseng Mayer. In the present study, we investigated whether Ppt could protect against 3-nitropropionic acid (3-NP)-induced oxidative stress in a rat model of Hunt...

    Yan Gao, Shi-feng Chu, Jian-** Li, Zhao Zhang, Jia-qing Yan in Acta Pharmacologica Sinica (2015)

  4. Article

    Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis

    To investigate the anti-fibrosis effects of ginsenoside Rg1 on alcohol- and CCl4-induced hepatic fibrosis in rats and to explore the mechanisms of the effects.

    Jian-** Li, Yan Gao, Shi-feng Chu, Zhao Zhang in Acta Pharmacologica Sinica (2014)

  5. Article

    Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats

    To investigate whether fluvastatin is able to ameliorate the impaired cardiac function or baroreflex sensitivity (BRS) in rats with type 1 diabetes.

    Fang **e, Chao Sun, Li-hua Sun, **g-yuan Li, **n Chen in Acta Pharmacologica Sinica (2011)

  6. Article

    Interferon-α enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis

    To determine whether interferon-α (IFNα) can enhance doxorubicin sensitivity in osteosarcoma cells and its molecular mechanism.

    **ang-wei Yuan, **ao-feng Zhu, **u-fang Huang, Pu-yi Sheng in Acta Pharmacologica Sinica (2007)