29 Result(s)
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Article
Open AccessC-reactive protein is a predictor for lower-extremity deep venous thrombosis in patients with primary intracerebral hemorrhage
Our study aimed to determine whether there exists an association between low-grade systemic inflammation, as measured by serum C-reactive protein (CRP), and the risk of lower-extremity deep venous thrombosis (...
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Open AccessCorrelation of serum and local CXCL13 levels with disease severity in patients with non-traumatic osteonecrosis of femoral head
The primary aim of the present study was to explore the potential correlation of serum / local CXCL13 expressions and disease severity in non-traumatic osteonecrosis of the femoral head (NT-ONFH).
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Immunometabolism: a new dimension in immunotherapy resistance
Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionized the paradigm of tumor treatment, while substantial patients remain unresponsive or develop resistance to...
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Open AccessFeasibility and reproducibility of semi-automated longitudinal strain analysis: a comparative study with conventional manual strain analysis
Conventional approach to myocardial strain analysis relies on a software designed for the left ventricle (LV) which is complex and time-consuming and is not specific for right ventricular (RV) and left atrial ...
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Article
Treatment of Irritable Bowel Syndrome by Chinese Medicine: A Review
Irritable bowel syndrome (IBS) is a common refractory disease. Chinese medicine (CM) has remarkable efficacy and advantages on the treatment of IBS. This review summarized the articles focusing on the treatmen...
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Open AccessExpert consensus on the monitoring and treatment of sepsis-induced immunosuppression
Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus...
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Translation and validation of the Chinese version of the orthorexia nervosa assessment questionnaires among college students
The main objective of the study was to translate, validate, and compare the Chinese ORTO scales (ORTO-15 and ORTO-R). The secondary objective was to assess factors that may be related with risk of orthorexia n...
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Ginsenoside Rg1 Reduces Cardiotoxicity While Increases Cardiotonic Effect of Aconitine in vitro
To explore the synergic mechanism of ginsenoside Rg1 (Rg1) and aconitine (AC) by acting on normal neonatal rat cardiomyocytes (NRCMs) and pentobarbital sodium (PS)-induced damaged NRCMs.
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Kang-Ai Injection Inhibits Gastric Cancer Cells Proliferation through IL-6/STAT3 Pathway
To explore the mechanisms underlying the proliferative inhibition of Chinese herbal medicine Kang-Ai injection (KAI) in gastric cancer cells.
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Article
Open AccessNew-onset COVID-19–related diabetes: an early indicator of multi-organ injury and mortally of SARS-CoV-2 infection
The pandemic of 2019 coronavirus (SARS-CoV-2) disease (COVID-19) has imposed a severe public health burden worldwide. Most patients with COVID-19 were mild. Severe patients progressed rapidly to critical condi...
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Open AccessPrevalence and associated factors of suicidal ideation among college students during the COVID-19 pandemic in China: a 3-wave repeated survey
The coronavirus disease 2019 (COVID-19) pandemic, a major public health crisis, harms individuals’ mental health. This 3-wave repeated survey aimed to examine the prevalence and correlates of suicidal ideation...
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Open AccessSimilarities and differences between rat and mouse chondrocyte gene expression induced by IL-1β
Osteoarthritis (OA) is the most prevalent degenerative joint disease. In vitro experiments are an intuitive method used to investigate its early pathogenesis. Chondrocyte inflammation models in rats and mice a...
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Article
Association of maternal folate use and reduced folate carrier gene polymorphisms with the risk of congenital heart disease in offspring
Although it is generally recognized that genetic and environmental factors are associated with the risk of congenital heart disease (CHD), the mechanism remains largely uncertain. This study aimed to investiga...
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Open AccessBedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China: focus on the safety
World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis (DR-TB) should develop and implement a system for active pharmacovigilance that a...
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Open AccessAnti-platelet aggregation of Panax notoginseng triol saponins by regulating GP1BA for ischemic stroke therapy
Panax notoginseng triol saponins (PTS) has been used clinically for ischemic stroke therapy (IST) in China for more than 17 years due to its anti-platelet aggregation and neuro-protective effects, but its mech...
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Open AccessCREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis
Epigenetic alterations play an important role in tumor progression of diffuse large B-cell lymphoma (DLBCL). However, the biological relevance of epigenetic gene mutations on tumor microenvironment remains to ...
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Open AccessCOVID-19 patients managed in psychiatric inpatient settings due to first-episode mental disorders in Wuhan, China: clinical characteristics, treatments, outcomes, and our experiences
Data are scarce regarding the comorbid mental disorders and their management among COVID-19 patients. This study described the clinical characteristics and management of COVID-19 patients treated in psychiatri...
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Exploring an Integrative Therapy for Treating COVID-19: A Randomized Controlled Trial
To develop a new Chinese medicine (CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome (ARDS) in COVID-19 patients.
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Open AccessAssociation between admission hypothermia and outcomes in very low birth weight infants in China: a multicentre prospective study
The objective of this prospective, multicentre, observational cohort study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants in multipl...
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Open AccessLocal adaptive evolution of two distinct clades of Bei**g and T families of Mycobacterium tuberculosis in Chongqing: a Bayesian population structure and phylogenetic study
Bei**g sub-pedigree 2 (BSP2) and T sub-lineage 6 (TSL6) are two clades belonging to Bei**g and T family of Mycobacterium tuberculosis (MTB), respectively, defined by Bayesian population structure analysis based...
