1,999 Result(s)
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Open AccessLarge-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults
The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 uni...
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Open AccessGLP-1 receptor agonists’ impact on cardio-renal outcomes and mortality in T2D with acute kidney disease
Previous studies have explored the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in reducing cardiovascular events in type 2 diabetes. Here we show that GLP-1 RAs are associated with lower r...
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Antiferromagnetic phase transition in a 3D fermionic Hubbard model
The fermionic Hubbard model (FHM)1 describes a wide range of physical phenomena resulting from strong electron–electron correlations, including conjectured mechanisms for unconventional superconductivity. Resolvi...
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Open AccessWavelength-tunable high-fidelity entangled photon sources enabled by dual Stark effects
The construction of a large-scale quantum internet requires quantum repeaters containing multiple entangled photon sources with identical wavelengths. Semiconductor quantum dots can generate entangled photon p...
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Open AccessLong-range inhibition from prelimbic to cingulate areas of the medial prefrontal cortex enhances network activity and response execution
It is well established that the medial prefrontal cortex (mPFC) exerts top-down control of many behaviors, but little is known regarding how cross-talk between distinct areas of the mPFC influences top-down si...
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Open AccessTuning electronic structure of metal-free dual-site catalyst enables exclusive singlet oxygen production and in-situ utilization
Develo** eco-friendly catalysts for effective water purification with minimal oxidant use is imperative. Herein, we present a metal-free and nitrogen/fluorine dual-site catalyst, enhancing the selectivity an...
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Open AccessAutomatic wild bird repellent system that is based on deep-learning-based wild bird detection and integrated with a laser rotation mechanism
Wild bird repulsion is critical in agriculture because it helps avoid agricultural food losses and mitigates the risk of avian influenza. Wild birds transmit avian influenza in poultry farms and thus cause lar...
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Open AccessThe association between acute myocardial infarction and subsequent diagnosis of breast cancer: a nationwide, population-based cohort study
Coronary artery disease (CAD) such as acute myocardial infarction (MI) share several common risk factors with cancers, and each disease may influence the prognosis of the other. Recently, acute MI was demonstr...
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Open AccessPerformance of Microsoft Azure Kinect DK as a tool for estimating human body segment lengths
The Microsoft Kinect depth sensor, with its built-in software that automatically captures joint coordinates without markers, could be a potential tool for ergonomic studies. This study investigates the perform...
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Open AccessEngineered droplet-forming peptide as photocontrollable phase modulator for fused in sarcoma protein
The assembly and disassembly of biomolecular condensates are crucial for the subcellular compartmentalization of biomolecules in the control of cellular reactions. Recently, a correlation has been discovered b...
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Open AccessEffects of edge disorder on the stability of quantum oscillations in two-dimensional coupled systems
This paper utilizes the theory of quantum diffusion to analyze the electron probability and spreading width of a wavepacket on each layer in a two-dimensional (2D) coupled system with edge disorder, aiming to ...
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Open AccessExploring the ecological security evaluation of water resources in the Yangtze River Basin under the background of ecological sustainable development
The Yangtze River (hereafter referred to as the YZR), the largest river in China, is of paramount importance for ensuring water resource security. The Yangtze River Basin (hereafter referred to as the YRB) is ...
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Open AccessUnraveling the energy storage mechanism in graphene-based nonaqueous electrochemical capacitors by gap-enhanced Raman spectroscopy
Graphene has been extensively utilized as an electrode material for nonaqueous electrochemical capacitors. However, a comprehensive understanding of the charging mechanism and ion arrangement at the graphene/e...
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Open AccessInvestigation on the contaminate of hand washing activities on the surface of environmental objects in intensive care unit
To detect the contaminate of faucets in hospitals and the splash during hand washing, and to explore the reasonable layout of hand washing pools. Two faucets with roughly the same spatial layout in the ICU of ...
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Open AccessStructural and functional characterization of cyclic pyrimidine-regulated anti-phage system
3’,5’-cyclic uridine monophosphate (cUMP) and 3’,5’-cyclic cytidine monophosphate (cCMP) have been established as bacterial second messengers in the phage defense system, named pyrimidine cyclase system for an...
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Open AccessIncreased risks of retinal vascular occlusion in patients with migraine and the protective effects of migraine treatment: a population-based retrospective cohort study
Associations between migraine and retinal vascular occlusion have been reported, but there is no large-scale and comprehensive study. Therefore, we aimed to determine risks of retinal vascular occlusion in pat...
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Open AccessOptimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue
Assessing programmed death ligand 1 (PD-L1) expression through immunohistochemistry (IHC) is the golden standard in predicting immunotherapy response of non-small cell lung cancer (NSCLC). However, observation...
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Open AccessMyricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson’s disease
Ferroptosis is an iron-dependent cell death form characterized by reactive oxygen species (ROS) overgeneration and lipid peroxidation. Myricetin, a flavonoid that exists in numerous plants, exhibits potent ant...
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Open AccessAssociation between admission pan-immune-inflammation value and short-term mortality in septic patients: a retrospective cohort study
Pan-Immune-Inflammation Value (PIV) has recently received more attention as a novel indicator of inflammation. We aimed to evaluate the association between PIV and prognosis in septic patients. Data were extra...
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Open AccessToF-SIMS evaluation of PEG-related mass peaks and applications in PEG detection in cosmetic products
Polyethylene glycols (PEGs) are used in industrial, medical, health care, and personal care applications. The cycling and disposal of synthetic polymers like PEGs pose significant environmental concerns. Detec...
