42 Result(s)

Article

SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex

Metastasis significantly reduces the survival rate of osteosarcoma (OS) patients. Therefore, identification of novel targets remains extremely important to prevent metastasis and treat OS. In this report, we s...

S-J Zhao, Y-Q Jiang, N-W Xu, Q Li, Q Zhang, S-Y Wang, J Li, Y-H Wang, Y-L Zhang… in Oncogene (2018)

Article

Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7–CYFIP1-mediated signaling pathway

The early onset breast cancer patients (age ≤ 40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecul...

Jer-Wei Chang, Wen-Hung Kuo, Chiao-Mei Lin, Wen-Ling Chen, Shih-Hsuan Chan… in Oncogene (2018)

Article

O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit

Advanced colorectal cancer (CRC) is one of the deadliest cancers, and the 5-year survival rate of patients with metastasis is extremely low. The epithelial–mesenchymal transition (EMT) is considered essential ...

Mingzuo Jiang, Bing Xu, **aowei Li, Yulong Shang, Yi Chu, Weijie Wang, Di Chen… in Oncogene (2019)

Article

EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer

Tyrosine kinase inhibitors for epidermal growth factor receptor (EGFR TKIs) greatly improved clinical outcomes of patients with non-small cell lung cancer (NSCLC). Unfortunately, primary and acquired resistanc...

Lixian Yang, Shilong Ying, Shiman Hu… in Signal Transduction and Targeted Therapy (2019)

Article

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation

Patients with stage II or III colorectal cancer (CRC) exhibit various clinical outcomes after radical treatments. The 5-year survival rate was between 50 and 87%. However, the underlying mechanisms of the vari...

Ying-Nan Wang, Yun-**n Lu, Jie Liu, Ying **, Hui-Chang Bi, Qi Zhao… in Oncogene (2020)

Article

Role of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue

Huan-**n Chen, Ming-Yang Li, Yi-Yao Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency

Yu-Shui Ma, **ao-Feng Wang, Fei Yu… in Signal Transduction and Targeted Therapy (2020)

Article

Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells

γδT cells have been reported to exert immunosuppressive functions in multiple solid malignant diseases, but their immunosuppressive functional subpopulation in breast cancer (BC) is still undetermined. Here, w...

Chao Ni, Qing-Qing Fang, Wu-Zhen Chen… in Signal Transduction and Targeted Therapy (2020)

Article

Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation

Galectin-9 (Gal-9) is known to enhance the expansion of myeloid-derived suppressor cells (MDSCs) in murine models. Its contribution to the expansion of MDSCs in human malignancies remain to be investigated. We...

Chuan-xia Zhang, Dai-jia Huang, Valentin Baloche, Lin Zhang, **g-xiao Xu… in Oncogenesis (2020)

Article

Augmented efficacy of exogenous extracellular vesicles targeted to injured kidneys

**ao-Jun Chen, Kai Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no specific and effective drugs for treating this disease have been reported until today. Angiotensin-converting enzyme ...

Ke Wang, Wei Chen, Zheng Zhang, Yongqiang Deng… in Signal Transduction and Targeted Therapy (2020)

Article

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the mechanisms underlying resi...

Junjie Xu, Lin Ji, Yuelong Liang, Zhe Wan… in Signal Transduction and Targeted Therapy (2020)

Article

Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

Mitochondrial fusion/fission dynamics plays a fundamental role in neuroprotection; however, there is still a severe lack of therapeutic targets for this biological process. Here, we found that the naturally de...

Ke-Wu Zeng, **g-Kang Wang, Li-Chao Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota

The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine and generates levodopa (l-dopa) w...

Yan Wang, Qian Tong, Shu-Rong Ma… in Signal Transduction and Targeted Therapy (2021)

Article

Correction: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

A Correction to this paper has been published: https://doi.org/10.1038/s41392-021-00533-3

Ke-Wu Zeng, **g-Kang Wang, Li-Chao Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Correction to: FMNL1 mediates nasopharyngeal carcinoma cell aggressiveness by epigenetically upregulating MTA1

A Correction to this paper has been published: https://doi.org/10.1038/s41388-021-01751-3

Wen-Hui Chen, Mu-Yan Cai, Jia-**ng Zhang, Feng-Wei Wang, Lin-Quan Tang… in Oncogene (2021)

Article

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus with high fatality and an expanding endemic. Currently, effective anti-SFTSV intervention remains unavailable. F...

Hao Li, **a-Ming Jiang, Ning Cui, Chun Yuan… in Signal Transduction and Targeted Therapy (2021)

Article

CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression

Major gaps in understanding the molecular mechanisms of colorectal cancer (CRC) progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal disorders. Trefoil factor 3 ...

Hong-Yong Cui, Shi-Jie Wang, Fei Song, Xu Cheng… in Signal Transduction and Targeted Therapy (2021)

Article

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...

Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu… in Signal Transduction and Targeted Therapy (2021)

Article

Correction: Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically down-regulating MTSS1 through DNMT3B

**ang-Dong Li, Jia-**ng Zhang, Li-Juan Jiang, Feng-Wei Wang, Lu-Lu Liu… in Oncogene (2021)